Fluctuating Course of Red Cell Distrubition Width in Treatment of Iron Deficiency Anemia and Its Clinical Relevance

SOLMAZ, SONER; Gereklioglu, Cigdem; ASMA, Süheyl; BOGA, Can; ÖZDOĞU, Hakan; Yeral, Mahmut; Kasar, Mutlu

Fluctuating Course of Red Cell Distrubition Width in Treatment of Iron Deficiency Anemia and Its Clinical Relevance

Soner SOLMAZ, (Çukurova Üniversitesi, Tıp Fakültesi, Eğitim ve Tıbbi Araştırma Merkezi, Hematoloji Bölümü, Adana, Türkiye)

Süheyl ASMA, (Çukurova Üniversitesi, Tıp Fakültesi, Aile Hekimliği Anabilim Dalı, Adana, Türkiye)

Çiğdem GEREKLİOĞLU, (Çukurova Üniversitesi, Tıp Fakültesi, Aile Hekimliği Anabilim Dalı, Adana, Türkiye)

Mutlu KASAR, (Çukurova Üniversitesi, Tıp Fakültesi, Eğitim ve Tıbbi Araştırma Merkezi, Hematoloji Bölümü, Adana, Türkiye)

Mahmut YERAL, (Çukurova Üniversitesi, Tıp Fakültesi, Eğitim ve Tıbbi Araştırma Merkezi, Hematoloji Bölümü, Adana, Türkiye)

Can BOGA, (Çukurova Üniversitesi, Tıp Fakültesi, Eğitim ve Tıbbi Araştırma Merkezi, Hematoloji Bölümü, Adana, Türkiye)

Hakan ÖZDOĞU (Çukurova Üniversitesi, Tıp Fakültesi, Eğitim ve Tıbbi Araştırma Merkezi, Hematoloji Bölümü, Adana, Türkiye)

Turkish Journal of Family Medicine and Primary Care

2 1

Yıl: 2015 Cilt: 9 Sayı: 3 Sayfa Aralığı: 83 - 87 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Fluctuating Course of Red Cell Distrubition Width in Treatment of Iron Deficiency Anemia and Its Clinical Relevance

Öz:

Giriş: RDW, kan sayımının rutin bir parametresidir. Bu parametrenin kullanımı genel olarak mikrositer anemilerin ayırıcı tanısıyla kısıtlıdır. Bununla birlikte literatürde demir eksikliği anemisinin tedavisinde RDW nin seyri ve klinik önemiyle ilgili yeteri kadar bilgi bulunmamaktadır. Bundan dolayı bu çalışmada RDW nin demir eksikliği anemisinin tedavisindeki seyri ve hemoglobin artışı ile ilişkisinin araştırılması amaçlanmıştır. Method: Demir eksikliği anemisi tanısı konulan 105 hasta bu çalışmaya alınmıştır. Bulgular: Tanı anındaki ve tedavi başlandıktan sonraki 1, 2 ve 3. aydaki ortalama hemoglobin değerleri sırasıyla 9.2±1.5, 11.7±1.0, 12.7±0.8 ve 13.1±0.8 g/dL, RDW değerleri sırasıyla %18.4±2.6, %26.4±6.5, %17.8±4.3 ve %14.7±1.7 bulundu. Tanı anında ve 1. aydaki RDW değerleri arasında istatistiksel olarak belirgin artış (p<0.0001), 1, 2 ve 3. aydaki RDW değerleri arasında belirgin azalma (p<0.0001) tespit edildi. Regresyon analizinde 1. aydaki RDW artışı ile 1, 2 ve 3. aylardaki hemoglobin artışları arasında doğrusal bir bağlantı olduğu görüldü (sırasıyla p<0.0001, r=0.461; p<0.0001, r=0.51; p<0.0001, r=0.472). Sonuç: Bu çalışmanın sonuçlarına göre, RDW de meydana gelen artışın demir tedavisi yanıtını öngördürmek için kullanılabileceğini düşünmekteyiz.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Demir Eksikliği Anemisi Tedavisinde RDW nin Dalgalı Seyri ve Klinik Önemi

Öz:

Background: Red cell distribution width (RDW) is a routine parameter of blood count. The use of this parameter is generally restricted to the differential diagnosis of microcytic anemia. However, there is insufficient published data on the course of RDW in the treatment of iron deficiency anemia and on its clinical importance. Therefore, this study investigated the course of RDW in the treatment of iron deficiency anemia and its association with increased hemoglobin values. Methods: One hundred five patients diagnosed with iron deficiency anemia were enrolled in this study. Results: The mean hemoglobin values of patients at diagnosis and at 1, 2 and 3 months after initiation of treatment were 9.2±1.5, 11.7±1.0, 12.7±0.8, and 13.1±0.8 g/dL, respectively. The mean RDW values of patients at diagnosis and 1, 2 and 3 months after initiation of treatment were 18.4±2.6, 26.4±6.5, 17.8±4.3, and 14.7±1.7%, respectively. Between baseline and 1 month of treatment there was a significant increase in RDW values (p<0.0001), and between 1, 2 and 3 months there was a significant decrease in RDW values (p<0.0001). Regression analysis revealed a linear correlation between the increase in RDW at month 1 and increase in hemoglobin level at months 1, 2 and 3 (p<0.0001, r=0.461; p<0.0001, r=0.51; p<0.0001, r=0.472, respectively). Conclusion: We suggest that an increase in RDW may be used to predict the response to iron treatment.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	SOLMAZ S, ASMA S, Gereklioglu C, Kasar M, Yeral M, BOGA C, ÖZDOĞU H (2015). Fluctuating Course of Red Cell Distrubition Width in Treatment of Iron Deficiency Anemia and Its Clinical Relevance. , 83 - 87.
Chicago	SOLMAZ SONER,ASMA Süheyl,Gereklioglu Cigdem,Kasar Mutlu,Yeral Mahmut,BOGA Can,ÖZDOĞU Hakan Fluctuating Course of Red Cell Distrubition Width in Treatment of Iron Deficiency Anemia and Its Clinical Relevance. (2015): 83 - 87.
MLA	SOLMAZ SONER,ASMA Süheyl,Gereklioglu Cigdem,Kasar Mutlu,Yeral Mahmut,BOGA Can,ÖZDOĞU Hakan Fluctuating Course of Red Cell Distrubition Width in Treatment of Iron Deficiency Anemia and Its Clinical Relevance. , 2015, ss.83 - 87.
AMA	SOLMAZ S,ASMA S,Gereklioglu C,Kasar M,Yeral M,BOGA C,ÖZDOĞU H Fluctuating Course of Red Cell Distrubition Width in Treatment of Iron Deficiency Anemia and Its Clinical Relevance. . 2015; 83 - 87.
Vancouver	SOLMAZ S,ASMA S,Gereklioglu C,Kasar M,Yeral M,BOGA C,ÖZDOĞU H Fluctuating Course of Red Cell Distrubition Width in Treatment of Iron Deficiency Anemia and Its Clinical Relevance. . 2015; 83 - 87.
IEEE	SOLMAZ S,ASMA S,Gereklioglu C,Kasar M,Yeral M,BOGA C,ÖZDOĞU H "Fluctuating Course of Red Cell Distrubition Width in Treatment of Iron Deficiency Anemia and Its Clinical Relevance." , ss.83 - 87, 2015.
ISNAD	SOLMAZ, SONER vd. "Fluctuating Course of Red Cell Distrubition Width in Treatment of Iron Deficiency Anemia and Its Clinical Relevance". (2015), 83-87.

APA	SOLMAZ S, ASMA S, Gereklioglu C, Kasar M, Yeral M, BOGA C, ÖZDOĞU H (2015). Fluctuating Course of Red Cell Distrubition Width in Treatment of Iron Deficiency Anemia and Its Clinical Relevance. Turkish Journal of Family Medicine and Primary Care, 9(3), 83 - 87.
Chicago	SOLMAZ SONER,ASMA Süheyl,Gereklioglu Cigdem,Kasar Mutlu,Yeral Mahmut,BOGA Can,ÖZDOĞU Hakan Fluctuating Course of Red Cell Distrubition Width in Treatment of Iron Deficiency Anemia and Its Clinical Relevance. Turkish Journal of Family Medicine and Primary Care 9, no.3 (2015): 83 - 87.
MLA	SOLMAZ SONER,ASMA Süheyl,Gereklioglu Cigdem,Kasar Mutlu,Yeral Mahmut,BOGA Can,ÖZDOĞU Hakan Fluctuating Course of Red Cell Distrubition Width in Treatment of Iron Deficiency Anemia and Its Clinical Relevance. Turkish Journal of Family Medicine and Primary Care, vol.9, no.3, 2015, ss.83 - 87.
AMA	SOLMAZ S,ASMA S,Gereklioglu C,Kasar M,Yeral M,BOGA C,ÖZDOĞU H Fluctuating Course of Red Cell Distrubition Width in Treatment of Iron Deficiency Anemia and Its Clinical Relevance. Turkish Journal of Family Medicine and Primary Care. 2015; 9(3): 83 - 87.
Vancouver	SOLMAZ S,ASMA S,Gereklioglu C,Kasar M,Yeral M,BOGA C,ÖZDOĞU H Fluctuating Course of Red Cell Distrubition Width in Treatment of Iron Deficiency Anemia and Its Clinical Relevance. Turkish Journal of Family Medicine and Primary Care. 2015; 9(3): 83 - 87.
IEEE	SOLMAZ S,ASMA S,Gereklioglu C,Kasar M,Yeral M,BOGA C,ÖZDOĞU H "Fluctuating Course of Red Cell Distrubition Width in Treatment of Iron Deficiency Anemia and Its Clinical Relevance." Turkish Journal of Family Medicine and Primary Care, 9, ss.83 - 87, 2015.
ISNAD	SOLMAZ, SONER vd. "Fluctuating Course of Red Cell Distrubition Width in Treatment of Iron Deficiency Anemia and Its Clinical Relevance". Turkish Journal of Family Medicine and Primary Care 9/3 (2015), 83-87.