Yıl: 2015 Cilt: 43 Sayı: 7 Sayfa Aralığı: 599 - 606 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Evaluation of aortic stiffness in Gilbert syndrome patients: a protective effect of elevated bilirubin levels

Öz:
Amaç: Gilbert sendromu (GS) indirekt bilirubin artışıyla karakterize otozomal resesif bir hastalıktır. Gilbert sendromundaaterosklerotik kalp hastalığı insidansı azalmıştır. Biz bu çalışmada GSnin varlığı ve nabız dalga hızı (NDH) arasındakiilişkiyi incelemeyi amaçladık. Yöntemler: Bu çalışmaya hastanemiz iç hastalıkları kliniğine başvuran 32 kadın (yaş: 27.12±7.27) ve 26 erkek (yaş:26.63±5.84) olmak üzere toplam 58 GSli hasta alındı. Kontrol grubu olarak benzer yaş grubunda olan 35 kadın (yaş:27.33±8.06, p=0.716) ve 23 erkek (yaş: 27.38±6.91, p=0.923)olmak üzere 58 sağlıklı katılımcı çalışmaya dahil edildi. Heriki grubun NDHsi sağ karotis ve femoral arterlerden ölçüldü. Bulgular: Gilbert sendromu grubunun yaş ortalaması26.03±8.22 yıl ve sağlıklı grubun yaş ortalaması 26.60±5.84yıl idi. Gilbert sendromu grubunun diyastolik kan basıncı (67.76±8.59 mmHg) ve NDHsi (5.63±1.12 m/s) kontrolgrubundan (71.72±7.28 mmHg, p=0.008; 6.18±1.22 m/s,p=0.014) anlamlı olarak daha düşüktü. Gilbert sendromu gru- bunun yüksek yoğunluklu lipoprotein düzeyi (1.4±0.3 mmol/L)kontrol grubundan (1.2±0.3 mmol/L mmol/L, p=0.029) anlamlışekilde daha yüksekti. Sonuç: Biz bu çalışmada, GSli hastaların NDH değerlerinisigara içmeyen, yaş uyumlu sağlıklı bireylerden düşük bulduk.
Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Gilbert sendromlu hastalarda aort sertliğinin değerlendirilmesi: Artmış bilirubin düzeyinin koruyucu etkisi

Öz:
Objective: Gilbert s syndrome (GS) is an autosomal reces- sive disease that is characterized by an increase in indirectbilirubin (IB). The incidence of atherosclerotic heart disease isdecreased in GS. This study aimed to investigate the relationbetween pulse wave velocity (PWV) and the presence of GS. Methods: The study included 58 GS patients (32 females,age; 27.12±7.27 years, 26 males, age; 26.63±5.84 years)admitted to the internal medicine clinic of the hospital. Thecontrol group included 58 healthy individuals (35 females[27.33±8.06 years old, p=0.716] and 23 males [27.38±6.91years old, p=0.923]). PWV of both groups was measured fromthe right carotid and femoral arteries. Results: Mean age of the GS group was 26.03±8.22 years,while that of the healthy group was 26.60±5.84 years. The GSgroup s diastolic blood pressure and PWV were significantlylower than those of the control group: 67.76±8.59 mmHg vs71.72±7.28 mmHg; p=0.008, and 5.63±1.12 m/s vs 6.18±1.22m/s; p=0.014 respectively. The GS group s high density lipo- protein (HDL) level was significantly higher than that of thecontrol group: 1.4±0.3 mmol/L vs 1.2±0.3 mmol/L, p=0.029. Conclusion: This study found PWV among GS patients tobe lower than that among non-smoking and aged-matchedhealthy controls.
Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Cüre E, Yüce S, Cüre MC. Gilbert’s Syndrome. Archives Medical Review Journal 2014;23:220–36.
  • 2. Cüre E, Yüce S, Ciçek Y, Cüre MC. The effect of Gilbert’s syndrome on the dispersions of QT interval and P-wave: an observational study. Anadolu Kardiyol Derg 2013;13:559–65.
  • 3. Cure MC, Cure E, Kirbas A, Cicek AC, Yuce S. The ef- fects of Gilbert’s syndrome on the mean platelet volume and other hematological parameters. Blood Coagul Fibrinolysis 2013;24:484–8.
  • 4. Tapan S, Karadurmus N, Dogru T, Ercin CN, Tasci I, Bilgi C, et al. Decreased small dense LDL levels in Gilbert’s syn- drome. Clin Biochem 2011;44:300–3.
  • 5. Erdogan T, Ciçek Y, Kocaman SA, Canga A, Cetin M, Du- rakoglugil E, et al. Increased serum bilirubin level is related to good collateral development in patients with chronic total coronary occlusion. Intern Med 2012;51:249–55.
  • 6. Horsfall LJ, Nazareth I, Pereira SP, Petersen I. Gilbert’s syn- drome and the risk of death: a population-based cohort study. J Gastroenterol Hepatol 2013;28:1643–7.
  • 7. Kamberi LS, Gorani DR, Hoxha TF, Zahiti BF. Aortic Com- pliance and Stiffness Among Severe Longstanding Hyperten- sive and Non-hypertensive. Acta Inform Med 2013;21:12–5.
  • 8. Cecelja M, Chowienczyk P. Dissociation of aortic pulse wave velocity with risk factors for cardiovascular disease other than hypertension: a systematic review. Hypertension 2009;54:1328–36.
  • 9. Sari I, Arican O, Can G, Akdeniz B, Akar S, Birlik M, et al. Assessment of aortic stiffness and ventricular functions in familial Mediterranean fever. Anadolu Kardiyol Derg 2008;8:271–8.
  • 10. Tedesco MA, Natale F, Di Salvo G, Caputo S, Capasso M, Calabró R. Effects of coexisting hypertension and type II diabetes mellitus on arterial stiffness. J Hum Hypertens 2004;18:469–73.
  • 11. Liu B, Che W, Yan H, Zhu W, Wang H. Effects of rosuvastatin vs. simvastatin/ezetimibe on arterial wall stiffness in patients with coronary artery disease. Intern Med 2013;52:2715–9.
  • 12. Frimodt-Møller M, Nielsen AH, Kamper AL, Strandgaard S. Reproducibility of pulse-wave analysis and pulse-wave ve- locity determination in chronic kidney disease. Nephrol Dial Transplant 2008;23:594–600.
  • 13. Arslan E, Çakar M, Şarlak H, Kılınç A, Demirbaş S, Ay SA, et al. Investigation of the aortic pulse wave velocity in patients with Gilbert’s syndrome. Clin Exp Hypertens 2013;35:512–5.
  • 14. Cüre E, Ciçek Y, Cumhur Cüre M, Yüce S, Kırbaş A, Yılmaz A. The evaluation of relationship between adiponectin lev- els and epicardial adipose tissue thickness with low cardiac risk in Gilbert`s syndrome: an observational study. Anadolu Kardiyol Derg 2013;13:791–6.
  • 15. Dufour DR, Lott JA, Nolte FS, Gretch DR, Koff RS, Seeff LB. Diagnosis and monitoring of hepatic injury. I. Performance characteristics of laboratory tests. Clin Chem 2000;46:2027– 49.
  • 16. Chen H, Hua Q, Hou H. Association of hemoglobin with am- bulatory arterial stiffness index in untreated essential hyper- tensive patients without anemia. Intern Med 2011;50:2759– 65.
  • 17. Kim SG, Kim HY, Seo JA, Lee KW, Oh JH, Kim NH, et al. Relationship between serum adiponectin concentration, pulse wave velocity and nonalcoholic fatty liver disease. Eur J En- docrinol 2005;152:225–31.
  • 18. Güray Y, Refiker M, Demirkan B, Güray U, Boyaci A, Kork- maz S. Aortic strain and distensibility in patients with meta- bolic syndrome. [Article in Turkish] Turk Kardiyol Dern Ars 2010;38:14–9.
  • 19. Wang J, Xu J, Zhou C, Zhang Y, Xu D, Guo Y, et al. Improve- ment of arterial stiffness by reducing oxidative stress damage in elderly hypertensive patients after 6 months of atorvastatin therapy. J Clin Hypertens (Greenwich) 2012;14:245–9.
  • 20. Rajendran P, Rengarajan T, Thangavel J, Nishigaki Y, Sakthisekaran D, Sethi G, et al. The vascular endothelium and human diseases. Int J Biol Sci 2013;9:1057–69.
  • 21. Wallner M, Marculescu R, Doberer D, Wolzt M, Wagner O, Vitek L, et al. Protection from age-related increase in lipid biomarkers and inflammation contributes to cardio- vascular protection in Gilbert’s syndrome. Clin Sci (Lond) 2013;125:257–64.
  • 22. Boon AC, Hawkins CL, Bisht K, Coombes JS, Bakrania B, Wagner KH, et al. Reduced circulating oxidized LDL is as- sociated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome. Free Radic Biol Med 2012;52:2120–7.
  • 23. van Bussel BC, Schouten F, Henry RM, Schalkwijk CG, de Boer MR, Ferreira I, et al. Endothelial dysfunction and low- grade inflammation are associated with greater arterial stiff- ness over a 6-year period. Hypertension 2011;58:588–95.
  • 24. Duprez DA, Somasundaram PE, Sigurdsson G, Hoke L, Flo- rea N, Cohn JN. Relationship between C-reactive protein and arterial stiffness in an asymptomatic population. J Hum Hy- pertens 2005;19:515–9.
  • 25. Oğuz A. Renin-angiotensin-aldosterone system inhibition and cardiovascular protection. [Article in Turkish] Turk Kardiyol Dern Ars 2009;37 Suppl 6:4–12.
  • 26. Vogiatzi G, Tousoulis D, Stefanadis C. The role of oxidative stress in atherosclerosis. Hellenic J Cardiol 2009;50:402–9.
  • 27. Root M, Collier SR, Zwetsloot KA, West KL, McGinn MC. A randomized trial of fish oil omega-3 fatty acids on arterial health, inflammation, and metabolic syndrome in a young healthy population. Nutr J 2013;12:40.
  • 28. Stec DE, Hosick PA, Granger JP. Bilirubin, renal hemody- namics, and blood pressure. Front Pharmacol 2012;3:18.
  • 29. Raghavan VA. Insulin resistance and atherosclerosis. Heart Fail Clin 2012;8:575–87.
  • 30. Vítek L, Kráslová I, Muchová L, Novotný L, Yamaguchi T. Urinary excretion of oxidative metabolites of bilirubin in subjects with Gilbert syndrome. J Gastroenterol Hepatol 2007;22:841–5.
  • 31. Ko GT, Chan JC, Woo J, Lau E, Yeung VT, Chow CC, et al. Serum bilirubin and cardiovascular risk factors in a Chinese population. J Cardiovasc Risk 1996;3:459–63.
  • 32. Dong H1, Huang H, Yun X, Kim DS, Yue Y, Wu H, et al. Bili- rubin increases insulin sensitivity in leptin-receptor deficient and diet-induced obese mice through suppression of ER stress and chronic inflammation. Endocrinology 2014;155:818–28.
  • 33. Wang B, Yu Y, Han L. Adiponectin improves endothe- lial dysfunction caused by elevated FFAs levels, partially through cAMP-dependent pathway. Diabetes Res Clin Pract 2012;97:119–24.
  • 34. Astolfi RH, Bugano DD, Francisco AA, de Souza MM, Ono- Nita SK, Baracat EC. Is Gilbert syndrome a new risk factor for breast cancer? Med Hypotheses 2011;77:162–4.
  • 35. Wohlfahrt P, Krajčoviechová A, Seidlerová J, Mayer O, Bru- thans J, Filipovský J, et al. Arterial stiffness parameters: how do they differ? Atherosclerosis 2013;231:359–64.
APA YÜCE S, CÜRE E, çiçek y, CÜRE M, YILMAZ A, KIZILKAYA B (2015). Evaluation of aortic stiffness in Gilbert syndrome patients: a protective effect of elevated bilirubin levels. , 599 - 606.
Chicago YÜCE Süleyman,CÜRE Erkan,çiçek yüksel gülen,CÜRE Medine Cumhur,YILMAZ Arif,KIZILKAYA Bayram Evaluation of aortic stiffness in Gilbert syndrome patients: a protective effect of elevated bilirubin levels. (2015): 599 - 606.
MLA YÜCE Süleyman,CÜRE Erkan,çiçek yüksel gülen,CÜRE Medine Cumhur,YILMAZ Arif,KIZILKAYA Bayram Evaluation of aortic stiffness in Gilbert syndrome patients: a protective effect of elevated bilirubin levels. , 2015, ss.599 - 606.
AMA YÜCE S,CÜRE E,çiçek y,CÜRE M,YILMAZ A,KIZILKAYA B Evaluation of aortic stiffness in Gilbert syndrome patients: a protective effect of elevated bilirubin levels. . 2015; 599 - 606.
Vancouver YÜCE S,CÜRE E,çiçek y,CÜRE M,YILMAZ A,KIZILKAYA B Evaluation of aortic stiffness in Gilbert syndrome patients: a protective effect of elevated bilirubin levels. . 2015; 599 - 606.
IEEE YÜCE S,CÜRE E,çiçek y,CÜRE M,YILMAZ A,KIZILKAYA B "Evaluation of aortic stiffness in Gilbert syndrome patients: a protective effect of elevated bilirubin levels." , ss.599 - 606, 2015.
ISNAD YÜCE, Süleyman vd. "Evaluation of aortic stiffness in Gilbert syndrome patients: a protective effect of elevated bilirubin levels". (2015), 599-606.
APA YÜCE S, CÜRE E, çiçek y, CÜRE M, YILMAZ A, KIZILKAYA B (2015). Evaluation of aortic stiffness in Gilbert syndrome patients: a protective effect of elevated bilirubin levels. Türk Kardiyoloji Derneği Arşivi, 43(7), 599 - 606.
Chicago YÜCE Süleyman,CÜRE Erkan,çiçek yüksel gülen,CÜRE Medine Cumhur,YILMAZ Arif,KIZILKAYA Bayram Evaluation of aortic stiffness in Gilbert syndrome patients: a protective effect of elevated bilirubin levels. Türk Kardiyoloji Derneği Arşivi 43, no.7 (2015): 599 - 606.
MLA YÜCE Süleyman,CÜRE Erkan,çiçek yüksel gülen,CÜRE Medine Cumhur,YILMAZ Arif,KIZILKAYA Bayram Evaluation of aortic stiffness in Gilbert syndrome patients: a protective effect of elevated bilirubin levels. Türk Kardiyoloji Derneği Arşivi, vol.43, no.7, 2015, ss.599 - 606.
AMA YÜCE S,CÜRE E,çiçek y,CÜRE M,YILMAZ A,KIZILKAYA B Evaluation of aortic stiffness in Gilbert syndrome patients: a protective effect of elevated bilirubin levels. Türk Kardiyoloji Derneği Arşivi. 2015; 43(7): 599 - 606.
Vancouver YÜCE S,CÜRE E,çiçek y,CÜRE M,YILMAZ A,KIZILKAYA B Evaluation of aortic stiffness in Gilbert syndrome patients: a protective effect of elevated bilirubin levels. Türk Kardiyoloji Derneği Arşivi. 2015; 43(7): 599 - 606.
IEEE YÜCE S,CÜRE E,çiçek y,CÜRE M,YILMAZ A,KIZILKAYA B "Evaluation of aortic stiffness in Gilbert syndrome patients: a protective effect of elevated bilirubin levels." Türk Kardiyoloji Derneği Arşivi, 43, ss.599 - 606, 2015.
ISNAD YÜCE, Süleyman vd. "Evaluation of aortic stiffness in Gilbert syndrome patients: a protective effect of elevated bilirubin levels". Türk Kardiyoloji Derneği Arşivi 43/7 (2015), 599-606.