Yıl: 2016 Cilt: 26 Sayı: 6 Sayfa Aralığı: 878 - 889 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Effectiveness of GFAP in Determining Neuronal Damage in Rats with Induced Head Trauma

Öz:
AIm: To determine whether the serum level of glial fibrillary acidic protein (GFAP), an important indicator of neuron damage, correlates with the extent of tissue damage in the rat with induced head trauma and to obtain data in order to avoid unnecessary cranial computed tomography analyses. mATERIAl and mEThODS: Three-month-old male Sprague-Dawley rats were used. Rats were divided into 5 groups. The experimental head trauma model was examined in five groups (n=8) as follows: The control group had no intervention; Group 1: Head trauma was induced by dropping a 25 mg ball from a height of 20 cm; Group 2: Head trauma was induced by dropping a 50 mg ball from a height of 20 cm; Group 3: Head trauma was induced by dropping a 50 mg ball from a height of 80 cm; Group 4: Head trauma was induced by dropping a 100 mg ball from a height of 80 cm. Thus, according to the Newton's Law, respectively 0.05, 0.1, 0.2 and 0.4 N trauma was created. Serum GFAP levels were analyzed and the damage to cerebral tissues was evaluated in all groups. RESUlTS: We determined that number of apoptotic cells and particularly the number of GFAP (+) protoplasmic astrocytes at the perilesional region of the cortex increased in association with the increased serum GFAP level as long as the severity of the trauma increased. CONClUSION: Serum GFAP concentration can be used as a marker of the severity of head trauma and traumatic brain injury. However, more animal studies are required to reflect this result in clinical practice
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Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA ÇIKRIKLAR H, Uysal O, EKİCİ M, ÖZBEK Z, COŞAN TURGUT D, Yücel M, YÜRÜMEZ Y, baydemir c (2016). Effectiveness of GFAP in Determining Neuronal Damage in Rats with Induced Head Trauma. , 878 - 889.
Chicago ÇIKRIKLAR HALİL İBRAHİM,Uysal Onur,EKİCİ Mehmet Ali,ÖZBEK Zühtü,COŞAN TURGUT Didem,Yücel Murat,YÜRÜMEZ Yusuf,baydemir canan Effectiveness of GFAP in Determining Neuronal Damage in Rats with Induced Head Trauma. (2016): 878 - 889.
MLA ÇIKRIKLAR HALİL İBRAHİM,Uysal Onur,EKİCİ Mehmet Ali,ÖZBEK Zühtü,COŞAN TURGUT Didem,Yücel Murat,YÜRÜMEZ Yusuf,baydemir canan Effectiveness of GFAP in Determining Neuronal Damage in Rats with Induced Head Trauma. , 2016, ss.878 - 889.
AMA ÇIKRIKLAR H,Uysal O,EKİCİ M,ÖZBEK Z,COŞAN TURGUT D,Yücel M,YÜRÜMEZ Y,baydemir c Effectiveness of GFAP in Determining Neuronal Damage in Rats with Induced Head Trauma. . 2016; 878 - 889.
Vancouver ÇIKRIKLAR H,Uysal O,EKİCİ M,ÖZBEK Z,COŞAN TURGUT D,Yücel M,YÜRÜMEZ Y,baydemir c Effectiveness of GFAP in Determining Neuronal Damage in Rats with Induced Head Trauma. . 2016; 878 - 889.
IEEE ÇIKRIKLAR H,Uysal O,EKİCİ M,ÖZBEK Z,COŞAN TURGUT D,Yücel M,YÜRÜMEZ Y,baydemir c "Effectiveness of GFAP in Determining Neuronal Damage in Rats with Induced Head Trauma." , ss.878 - 889, 2016.
ISNAD ÇIKRIKLAR, HALİL İBRAHİM vd. "Effectiveness of GFAP in Determining Neuronal Damage in Rats with Induced Head Trauma". (2016), 878-889.
APA ÇIKRIKLAR H, Uysal O, EKİCİ M, ÖZBEK Z, COŞAN TURGUT D, Yücel M, YÜRÜMEZ Y, baydemir c (2016). Effectiveness of GFAP in Determining Neuronal Damage in Rats with Induced Head Trauma. Turkish Neurosurgery, 26(6), 878 - 889.
Chicago ÇIKRIKLAR HALİL İBRAHİM,Uysal Onur,EKİCİ Mehmet Ali,ÖZBEK Zühtü,COŞAN TURGUT Didem,Yücel Murat,YÜRÜMEZ Yusuf,baydemir canan Effectiveness of GFAP in Determining Neuronal Damage in Rats with Induced Head Trauma. Turkish Neurosurgery 26, no.6 (2016): 878 - 889.
MLA ÇIKRIKLAR HALİL İBRAHİM,Uysal Onur,EKİCİ Mehmet Ali,ÖZBEK Zühtü,COŞAN TURGUT Didem,Yücel Murat,YÜRÜMEZ Yusuf,baydemir canan Effectiveness of GFAP in Determining Neuronal Damage in Rats with Induced Head Trauma. Turkish Neurosurgery, vol.26, no.6, 2016, ss.878 - 889.
AMA ÇIKRIKLAR H,Uysal O,EKİCİ M,ÖZBEK Z,COŞAN TURGUT D,Yücel M,YÜRÜMEZ Y,baydemir c Effectiveness of GFAP in Determining Neuronal Damage in Rats with Induced Head Trauma. Turkish Neurosurgery. 2016; 26(6): 878 - 889.
Vancouver ÇIKRIKLAR H,Uysal O,EKİCİ M,ÖZBEK Z,COŞAN TURGUT D,Yücel M,YÜRÜMEZ Y,baydemir c Effectiveness of GFAP in Determining Neuronal Damage in Rats with Induced Head Trauma. Turkish Neurosurgery. 2016; 26(6): 878 - 889.
IEEE ÇIKRIKLAR H,Uysal O,EKİCİ M,ÖZBEK Z,COŞAN TURGUT D,Yücel M,YÜRÜMEZ Y,baydemir c "Effectiveness of GFAP in Determining Neuronal Damage in Rats with Induced Head Trauma." Turkish Neurosurgery, 26, ss.878 - 889, 2016.
ISNAD ÇIKRIKLAR, HALİL İBRAHİM vd. "Effectiveness of GFAP in Determining Neuronal Damage in Rats with Induced Head Trauma". Turkish Neurosurgery 26/6 (2016), 878-889.