The Effect of Ozone Therapy on Experimental Vasospasm in the Rat Femoral Artery

uslu, serap; MERIC CINGU, Zeynep; ORAKDÖĞEN, Metin; Hakan, Tayfun; EMON TURAL, Selin; Somay, Hakan

The Effect of Ozone Therapy on Experimental Vasospasm in the Rat Femoral Artery

Metin ORAKDÖĞEN, (SB Haydarpaşa Numune Eğitim ve Araştırma Hastanesi, Nöroşirürji Kliniği, İstanbul, Türkiye)

Serap USLU, (Acıbadem Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Histoloji ve Embriyoloji Anabilim Dalı, İstanbul, Türkiye)

Selin EMON TURAL, (SB Haydarpaşa Numune Eğitim ve Araştırma Hastanesi, Nöroşirürji Kliniği, İstanbul, Türkiye)

Hakan SOMAY, (SB Haydarpaşa Numune Eğitim ve Araştırma Hastanesi, Nöroşirürji Kliniği, İstanbul, Türkiye)

Zeynep MERIC CINGU, (Ataşehir Ozon Merkezi, İstanbul, Türkiye)

Tayfun HAKAN (Özel Uygulama, Nöroşirürji, İstanbul, Türkiye)

Turkish Neurosurgery

6 0

Yıl: 2016 Cilt: 26 Sayı: 6 Sayfa Aralığı: 860 - 865 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

The Effect of Ozone Therapy on Experimental Vasospasm in the Rat Femoral Artery

Öz:

AIm: Oxidation products following subarachnoid hemorrhage (SAH) are among the causative substances of cerebral vasospasm and poor outcome. Ozone (O3) is a gas that contains three atoms of oxygen with a cyclic structure. It has been suggested that application of low-dose ozone has an antioxidant effect and provides resistance to oxidative stress. We investigated the effect of oxygen-ozone therapy on rat femoral artery vasospasm. mATERIAl and mEThODS: Twenty-four male Sprague-Dawley rats were randomly separated into vasospasm, vasospasm + ozone and control groups. The femoral artery vasospasm model was used. Rats in the vasospasm + ozone group were given 4 mL of ozone (20 µ/mL) daily for 7 days. Femoral arteries were examined by light microscopy for histological changes and morphometric analysis. Kruskal Wallis test and Mann Whitney u tests were used for the statistical analysis. The values of p<0.01 and p<0.05 were recognized as statistically significant. RESUlTS: Ozone treatment reduced the morphometric changes as irregularity of the elastic lamina, disruption of the endothelial cells, vacuolization and hemorrhages that caused by vasospasm. The measurements of the wall thickness (p=0.003; p<0.01) and lumen diameter (p=0.001; p<0.01) showed statistically significant difference (p < 0.01) between the vasospasm and vasospasm+ozone groups. CONClUSION: Ozone therapy may be useful in the treatment of post-hemorrhagic vasospasm

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ORAKDÖĞEN M, uslu s, EMON TURAL S, Somay H, MERIC CINGU Z, Hakan T (2016). The Effect of Ozone Therapy on Experimental Vasospasm in the Rat Femoral Artery. , 860 - 865.
Chicago	ORAKDÖĞEN Metin,uslu serap,EMON TURAL Selin,Somay Hakan,MERIC CINGU Zeynep,Hakan Tayfun The Effect of Ozone Therapy on Experimental Vasospasm in the Rat Femoral Artery. (2016): 860 - 865.
MLA	ORAKDÖĞEN Metin,uslu serap,EMON TURAL Selin,Somay Hakan,MERIC CINGU Zeynep,Hakan Tayfun The Effect of Ozone Therapy on Experimental Vasospasm in the Rat Femoral Artery. , 2016, ss.860 - 865.
AMA	ORAKDÖĞEN M,uslu s,EMON TURAL S,Somay H,MERIC CINGU Z,Hakan T The Effect of Ozone Therapy on Experimental Vasospasm in the Rat Femoral Artery. . 2016; 860 - 865.
Vancouver	ORAKDÖĞEN M,uslu s,EMON TURAL S,Somay H,MERIC CINGU Z,Hakan T The Effect of Ozone Therapy on Experimental Vasospasm in the Rat Femoral Artery. . 2016; 860 - 865.
IEEE	ORAKDÖĞEN M,uslu s,EMON TURAL S,Somay H,MERIC CINGU Z,Hakan T "The Effect of Ozone Therapy on Experimental Vasospasm in the Rat Femoral Artery." , ss.860 - 865, 2016.
ISNAD	ORAKDÖĞEN, Metin vd. "The Effect of Ozone Therapy on Experimental Vasospasm in the Rat Femoral Artery". (2016), 860-865.

APA	ORAKDÖĞEN M, uslu s, EMON TURAL S, Somay H, MERIC CINGU Z, Hakan T (2016). The Effect of Ozone Therapy on Experimental Vasospasm in the Rat Femoral Artery. Turkish Neurosurgery, 26(6), 860 - 865.
Chicago	ORAKDÖĞEN Metin,uslu serap,EMON TURAL Selin,Somay Hakan,MERIC CINGU Zeynep,Hakan Tayfun The Effect of Ozone Therapy on Experimental Vasospasm in the Rat Femoral Artery. Turkish Neurosurgery 26, no.6 (2016): 860 - 865.
MLA	ORAKDÖĞEN Metin,uslu serap,EMON TURAL Selin,Somay Hakan,MERIC CINGU Zeynep,Hakan Tayfun The Effect of Ozone Therapy on Experimental Vasospasm in the Rat Femoral Artery. Turkish Neurosurgery, vol.26, no.6, 2016, ss.860 - 865.
AMA	ORAKDÖĞEN M,uslu s,EMON TURAL S,Somay H,MERIC CINGU Z,Hakan T The Effect of Ozone Therapy on Experimental Vasospasm in the Rat Femoral Artery. Turkish Neurosurgery. 2016; 26(6): 860 - 865.
Vancouver	ORAKDÖĞEN M,uslu s,EMON TURAL S,Somay H,MERIC CINGU Z,Hakan T The Effect of Ozone Therapy on Experimental Vasospasm in the Rat Femoral Artery. Turkish Neurosurgery. 2016; 26(6): 860 - 865.
IEEE	ORAKDÖĞEN M,uslu s,EMON TURAL S,Somay H,MERIC CINGU Z,Hakan T "The Effect of Ozone Therapy on Experimental Vasospasm in the Rat Femoral Artery." Turkish Neurosurgery, 26, ss.860 - 865, 2016.
ISNAD	ORAKDÖĞEN, Metin vd. "The Effect of Ozone Therapy on Experimental Vasospasm in the Rat Femoral Artery". Turkish Neurosurgery 26/6 (2016), 860-865.