Exercise heart rate recovery assessment of the cardiac autonomic nervous system in workers occupationally exposed to lead

KARAKULAK, Uğur Nadir; ONAY, Emine Ercan; Evranos, Banu; AYTÜRK, Mehmet; TUTKUN, Engin; Gunduzoz, Meside; ÖZTÜRK TEK, Müjgan; Yılmaz, Ömer Hinç

Exercise heart rate recovery assessment of the cardiac autonomic nervous system in workers occupationally exposed to lead

Uğur Nadir KARAKULAK, (Ankara Meslek Hastalıkları ve Doğum Hastanesi, Kardiyoloji Kliniği, Ankara, Türkiye)

Ömer Hınç YILMAZ, (Ankara Meslek Hastalıkları ve Doğum Hastanesi, Klinik Toksikoloji Anabilim Dalı, Ankara, Türkiye)

Engin TUTKUN, (Ankara Meslek Hastalıkları ve Doğum Hastanesi, Klinik Toksikoloji Anabilim Dalı, Ankara, Türkiye)

Meside GÜNDÜZÖZ, (Ankara Meslek Hastalıkları ve Doğum Hastanesi, Klinik Toksikoloji Anabilim Dalı, Ankara, Türkiye)

Banu EVRANOS, (Hacettepe Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Ankara, Türkiye)

Emine Ercan ONAY, (Ankara Meslek Hastalıkları ve Doğum Hastanesi, Kardiyoloji Kliniği, Ankara, Türkiye)

Mehmet AYTÜRK, (Keçiören Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Ankara, Türkiye)

Müjgan ÖZTÜRK TEK (Keçiören Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Ankara, Türkiye)

Türk Kardiyoloji Derneği Arşivi

2 1

Yıl: 2016 Cilt: 44 Sayı: 5 Sayfa Aralığı: 371 - 379 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Exercise heart rate recovery assessment of the cardiac autonomic nervous system in workers occupationally exposed to lead

Öz:

Amaç: Bu yazıda, mesleki olarak kurşuna maruz kalan işçilerde kalp hızı toparlanma indeksi (KHTİ) ile kardiyak otonom işlevlerin değerlendirilmesi amaçlandı.Yöntemler: Kurşuna maruz kalan 98 işçi ile 98 kişilik sağlıklı kontrol grubu çalışmaya alındı. Tüm bireylere egzersiz testi ve transtorasik ekokardiyografi incelemeleri yapıldı. Birinci, ikinci ve üçüncü dakika KHTİ değerleri maksimum kalp hızı değerinden çıkarılarak hesaplandı. Her iki grup özellikle KHTİ olmak üzere egzersiz test parametreleri açısından değerlendirildi ve bu parametreler ile kan ve 24 saatlik idrarda kurşun düzeylerinin korelasyon analizi yapıldı.Bulgular: Her iki grup temel demografik ve klinik özellikleri açısında benzerdi. Ortalama birinci dakika KHTİ (26.2±3.6 ve 29.0±4.1 /dk, p<0.001), ikinci dakika KHTİ (42.6±3.9 ve 46.9±3.7 /dk, p<0.001) ve üçüncü dakika KHTİ (56.6±4.5 ve 61.8±4.3 /dk, p<0.001) değerleri kurşuna maruz kalan işçilerde sağlıklı kontrol grubuna gore anlamlı olarak daha düşüktü. Birinci dakika KHTİ, kan kurşun (r=-0.415, p<0.001) ve 24 saat idrarda kurşun (r=-0.446, p<0.001) düzeyleri ile anlamlı korelasyon gösterdi. İkinci ve üçüncü dakika KHTİ 24 saatlik idrarda kurşun düzeyi ile anlamlı korelasyon gösterdi (r=-0.396, p<0.001 ve r=-0.233, p=0.021).Sonuç: Kurşuna maruz kalan işçiler normal bireylere kıyasla daha düşük KHTİ değerlerine sahiptir. Kan ve 24 saatlik idrarda kurşun düzeyleri KHTİ'leri ile anlamlı olarak koreledir. Kurşuna maruz kalma durumunda kardiyak otonom işlevler olumsuz etkilenebilmektedir ve maruz kalan işçiler olumsuz kardiyovasküler sonlanımlar açısından yakından izlenmelidirler.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Mesleki olarak kurşuna maruz kalan işçilerde kardiyak otonom sinir sisteminin kalp hızı toparlanma indeksi ile değerlendirilmesi

Öz:

Objective: The aim of the present study was to assess cardiac autonomic function via indices of exercise heart rate recovery (HRR) in workers occupationally exposed to lead.Methods: A total of 98 lead-exposed workers and 98 healthy controls were enrolled. All underwent exercise testing and transthoracic echocardiography. HRR indices were calculated by subtracting 1st- (HRR1), 2nd- (HRR2), and 3rd-minute (HRR3) heart rates from maximal heart rate (HR). Exercise test parameters- HRR in particular- were compared between groups, and correlation analysis of blood, 24-hour urine lead levels, and test parameters was performed.Results: Baseline demographic and clinical characteristics were found to be similar between groups. Mean HRR1 (26.2±3.6 vs 29.0±4.1 bpm, p<0.001), HRR2 (42.6±3.9 vs 46.9±3.7 bpm, p<0.001), and HRR3 (56.6±4.5 vs 61.8±4.3 bpm, p<0.001) values were significantly lower in the leadexposed group than in the healthy controls. HRR1 was found to be significantly correlated with blood (r:-0.415; p<0.001) and 24-hour urine lead levels (r:-0.446; p<0.001). HRR2 and HRR3 were significantly correlated with 24-hour urine lead level (r:-0.396; p<0.001 and r:-0.233; p=0.021, respectively).Conclusion: Lead-exposed workers had lower HRR indices than normal subjects. Blood and 24-hour urine lead levels were significantly associated with HRR indices. Cardiac autonomic functions may be affected by exposure to lead, and those occupationally exposed should be closely followed for adverse cardiovascular outcome.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KARAKULAK U, Yılmaz Ö, TUTKUN E, Gunduzoz M, Evranos B, ONAY E, AYTÜRK M, ÖZTÜRK TEK M (2016). Exercise heart rate recovery assessment of the cardiac autonomic nervous system in workers occupationally exposed to lead. , 371 - 379.
Chicago	KARAKULAK Uğur Nadir,Yılmaz Ömer Hinç,TUTKUN Engin,Gunduzoz Meside,Evranos Banu,ONAY Emine Ercan,AYTÜRK Mehmet,ÖZTÜRK TEK Müjgan Exercise heart rate recovery assessment of the cardiac autonomic nervous system in workers occupationally exposed to lead. (2016): 371 - 379.
MLA	KARAKULAK Uğur Nadir,Yılmaz Ömer Hinç,TUTKUN Engin,Gunduzoz Meside,Evranos Banu,ONAY Emine Ercan,AYTÜRK Mehmet,ÖZTÜRK TEK Müjgan Exercise heart rate recovery assessment of the cardiac autonomic nervous system in workers occupationally exposed to lead. , 2016, ss.371 - 379.
AMA	KARAKULAK U,Yılmaz Ö,TUTKUN E,Gunduzoz M,Evranos B,ONAY E,AYTÜRK M,ÖZTÜRK TEK M Exercise heart rate recovery assessment of the cardiac autonomic nervous system in workers occupationally exposed to lead. . 2016; 371 - 379.
Vancouver	KARAKULAK U,Yılmaz Ö,TUTKUN E,Gunduzoz M,Evranos B,ONAY E,AYTÜRK M,ÖZTÜRK TEK M Exercise heart rate recovery assessment of the cardiac autonomic nervous system in workers occupationally exposed to lead. . 2016; 371 - 379.
IEEE	KARAKULAK U,Yılmaz Ö,TUTKUN E,Gunduzoz M,Evranos B,ONAY E,AYTÜRK M,ÖZTÜRK TEK M "Exercise heart rate recovery assessment of the cardiac autonomic nervous system in workers occupationally exposed to lead." , ss.371 - 379, 2016.
ISNAD	KARAKULAK, Uğur Nadir vd. "Exercise heart rate recovery assessment of the cardiac autonomic nervous system in workers occupationally exposed to lead". (2016), 371-379.

APA	KARAKULAK U, Yılmaz Ö, TUTKUN E, Gunduzoz M, Evranos B, ONAY E, AYTÜRK M, ÖZTÜRK TEK M (2016). Exercise heart rate recovery assessment of the cardiac autonomic nervous system in workers occupationally exposed to lead. Türk Kardiyoloji Derneği Arşivi, 44(5), 371 - 379.
Chicago	KARAKULAK Uğur Nadir,Yılmaz Ömer Hinç,TUTKUN Engin,Gunduzoz Meside,Evranos Banu,ONAY Emine Ercan,AYTÜRK Mehmet,ÖZTÜRK TEK Müjgan Exercise heart rate recovery assessment of the cardiac autonomic nervous system in workers occupationally exposed to lead. Türk Kardiyoloji Derneği Arşivi 44, no.5 (2016): 371 - 379.
MLA	KARAKULAK Uğur Nadir,Yılmaz Ömer Hinç,TUTKUN Engin,Gunduzoz Meside,Evranos Banu,ONAY Emine Ercan,AYTÜRK Mehmet,ÖZTÜRK TEK Müjgan Exercise heart rate recovery assessment of the cardiac autonomic nervous system in workers occupationally exposed to lead. Türk Kardiyoloji Derneği Arşivi, vol.44, no.5, 2016, ss.371 - 379.
AMA	KARAKULAK U,Yılmaz Ö,TUTKUN E,Gunduzoz M,Evranos B,ONAY E,AYTÜRK M,ÖZTÜRK TEK M Exercise heart rate recovery assessment of the cardiac autonomic nervous system in workers occupationally exposed to lead. Türk Kardiyoloji Derneği Arşivi. 2016; 44(5): 371 - 379.
Vancouver	KARAKULAK U,Yılmaz Ö,TUTKUN E,Gunduzoz M,Evranos B,ONAY E,AYTÜRK M,ÖZTÜRK TEK M Exercise heart rate recovery assessment of the cardiac autonomic nervous system in workers occupationally exposed to lead. Türk Kardiyoloji Derneği Arşivi. 2016; 44(5): 371 - 379.
IEEE	KARAKULAK U,Yılmaz Ö,TUTKUN E,Gunduzoz M,Evranos B,ONAY E,AYTÜRK M,ÖZTÜRK TEK M "Exercise heart rate recovery assessment of the cardiac autonomic nervous system in workers occupationally exposed to lead." Türk Kardiyoloji Derneği Arşivi, 44, ss.371 - 379, 2016.
ISNAD	KARAKULAK, Uğur Nadir vd. "Exercise heart rate recovery assessment of the cardiac autonomic nervous system in workers occupationally exposed to lead". Türk Kardiyoloji Derneği Arşivi 44/5 (2016), 371-379.