In this case report we present autologous serum treatment for corneoscleral dellen developing after an uneventful pterygium surgery with limbal conjunctival autograft. A 52-year-old male patient presenting with symptoms of stinging and redness in the left eye was diagnosed with nasal primary pterygium. Left nasal pterygium excision and conjunctival autograft implantation were performed without an adjunctive antimetabolite therapy. The graft was necrotic and liquefied on the postoperative 11th day despite topical steroid, antibiotic, and artificial tear administration. There was corneoscleral dellen. Upon which topical steroid application was stopped and the frequency of artificial tear administration was increased (24x1). Corneoscleral dellen did not regress on the postoperative 15th day the despite addition of lubricant gels/ointment to the treatment. Subsequently autologous serum drops at a concentration of 30% were also added to the treatment. Corneal dellen was completely healed and scleral re-surfacing was observed on the postoperative 22nd day. In conclusion, we believe that autologous serum administration should be considered among the treatment options when wide corneoscleral dellen formations, which are resistant to conventional treatments, are seen in patients.