Yıl: 2015 Cilt: 37 Sayı: 4 Sayfa Aralığı: 125 - 127 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Does Money Spent on Measuring Blood Levels of Acetaminophen Reduce the Cost of Treatment of Acetaminophen Poisoning?

Öz:
Objective: Acetaminophen has been used as a safe analgesic and antipyretic. Acute ingestion of 10 g or more than 200 mg/kg as a single ingestion is accepted as toxic for adults. To show that money spent on measuring blood levels of acetaminophen reduces the cost of treatment of acetaminophen poisoning. Materials and Methods: The files of patients who were admitted to Kayseri Training and Research Hospital with pre-diagnosis of acetaminophen intoxication were examined over 6 months. One of the costs is based on the patients' own estimation of the toxic level of acetaminophen and the other is according to the measure of the toxic blood level of acetaminophen. The cost of the two groups was compared. Results: A total of 558 patients were diagnosed to have drug overdose during 6 months. Of these patients, 55 patients were evaluated as having acetaminophen overdose. According to the claims of 19 patients, acetaminophen level was calculated as toxic. However, only five patients' blood acetaminophen level was measured as toxic. Conclusion: Measuring blood acetaminophen level would be more accurate and advantageous in terms of both treatment planning and the cost of therapy in developing countries as in developed countries that have advanced healthcare system.
Anahtar Kelime:

Konular: Genel ve Dahili Tıp
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • Hodgman MJ, Garrard AR. A Review of Acetaminophen Poisoning. Crit Care Clin 2012; 28(4): 499-516. [CrossRef]
  • Ferner RE, Dear JW, Bateman DN. Management of paracetamol poi- soning. BMJ 2011; 342: d2218. [CrossRef]
  • Duran L, Şişman B, Doğruel C, Yardan T, Baydın A, Yavuz Y. Use of Intravenous N-Acetyl Systein in Paracetamol Intoxication Eurasian J Emerg Med 2011; 10(4): 145-7.
  • Pettie J, Dow M. Assessment and management of paracetamol poi- soning in adults. Nurs Stand 2013; 27(47): 39-47. [CrossRef]
  • Ramlawi M, Marti C, Sarasin F. Paracetamol overdose. Rev Med Su- isse. 2013; 9(394): 1478-82.
  • Jang HS, Kim JY, Choi SH, Yoon YH, Moon SW, Hong YS, et al. Comparative Analysis of Acute Toxic Poisoning in 2003 and 2011: Analysis of 3 Academic Hospitals. J Korean Med Sci 2013; 28(10): 1424-30. [CrossRef]
  • Senarathna G, Ranganathan SR, Buckley N, Fernandopulle R. A cost effectiveness analysis of the preferred antidotes for acute paracetamol poisoning patients in Sri Lanka. BMC Clin Pharmacol 2012; 12: 6. [CrossRef]
  • Pettie J, Dow M. Management of poisoning in adults. Nurs Stand 2013; 27(45): 43-9. [CrossRef]
  • Carroll R, Benger J, Bramley K, Williams S, Griffin L, Potokar J, et al. Epidemiology, management and outcome of paracetamol poisoning in an inner city emergency department. Emerg Med J 2015; 32: 155-60. [CrossRef]
  • Bronstein AC, Spyker DA, Cantilena LR, Green JL, Rumack BH, Gif- fin SL. 2009 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 27th Annual Report. Clin Toxicol (Phila) 2010; 48(10): 979-1178. [CrossRef]
  • Rumack BH. Acetaminophen hepatotoxicity: the first 35 years. J Toxicol Clin Toxicol 2002; 40(1): 3-20. [CrossRef]
  • Duffull SB, Isbister GK. Predicting the requirement for N-acetylcyste- ine in paracetamol poisoning from reported dose. Clin Toxicol (Phila) 2013; 51(8): 772-6. [CrossRef]
  • Lavonas EJ, Beuhler MC, Ford MD, Kerns WP, Rouse AM, Tomasze- wski CA, et al. Intravenous administration of Nacetylcysteine: oral and parenteral formulations are both acceptable. Ann Emerg Med 2005; 45(2): 223-4. [CrossRef]
  • Wiegand T, Wax P, Smith E, Hart K, Brent J. The Toxicology In- vestigators Consortium Case Registry-The 2012 Experience. J Med Toxicol 2013; 9(4): 380-404. [CrossRef]
  • Martello JL, Pummer TL, Krenzelok EP. Cost minimization analysis comparing enteral N-acetylcysteine to intravenous acetylcysteine in the management of acute acetaminophen toxicity. Clin Toxicol (Phila) 2010; 48(1): 79-83. [CrossRef]
  • Yarema MC, Johnson DW, Berlin RJ, Sivilotti ML, Nettel-Aguirre A, Brant RF, et al. Comparison of the 20-hour intravenous and 72-hour oral acetylcysteine protocols for the treatment of acute acetamino- phen poisoning. Ann Emerg Med 2009; 54(4): 606-14. [CrossRef]
  • Klein-Schwartz W, Doyon S. Intravenous acetylcysteine for the treat- ment of acetaminophen overdose. Expert Opin Pharmacother 2011; 12(1): 119-30. [CrossRef]
  • Kociancic T, Reed MD. Acetaminophen intoxication and length of treatment: how long is long enough? Pharmacotherapy 2003; 23(8): 1052-9. [CrossRef]
  • Merl W, Koutsogiannis Z, Kerr D, Kelly AM. How safe is intrave- nous N-acetylcysteine for the treatment of paracetamol poisoning? Hong Kong J Emerg Med 2007; 14(4): 198-203.
  • Buckley NA, Eddleston M, Li J. IV versus Oral Acetylcysteine. Ann Emerg Med 2010; 55(4): 393-4. [CrossRef]
  • Gupta AK, Su MK, Greller HA, Lee DC, Chan GM. IV versus Oral N-acetylcysteine. Ann Emerg Med 2009; 54(6): 857-8. [CrossRef]
  • Kanter MZ. Comparison of oral and i.v. acetylcysteine in the treat- ment of acetaminophen poisoning. Am J Health-Syst Pharm 2006; 63(19): 1821-7. [CrossRef] 127
APA ÇEBİÇCİ H, KİLCİ A, Bol O, GÜRBÜZ S, VURAL A, Karaca B, CAKIR I (2015). Does Money Spent on Measuring Blood Levels of Acetaminophen Reduce the Cost of Treatment of Acetaminophen Poisoning?. , 125 - 127.
Chicago ÇEBİÇCİ Hüseyin,KİLCİ Ali İhsan,Bol Oğuzhan,GÜRBÜZ SÜKRÜ,VURAL Abdussamed,Karaca Bahadır,CAKIR Isil Does Money Spent on Measuring Blood Levels of Acetaminophen Reduce the Cost of Treatment of Acetaminophen Poisoning?. (2015): 125 - 127.
MLA ÇEBİÇCİ Hüseyin,KİLCİ Ali İhsan,Bol Oğuzhan,GÜRBÜZ SÜKRÜ,VURAL Abdussamed,Karaca Bahadır,CAKIR Isil Does Money Spent on Measuring Blood Levels of Acetaminophen Reduce the Cost of Treatment of Acetaminophen Poisoning?. , 2015, ss.125 - 127.
AMA ÇEBİÇCİ H,KİLCİ A,Bol O,GÜRBÜZ S,VURAL A,Karaca B,CAKIR I Does Money Spent on Measuring Blood Levels of Acetaminophen Reduce the Cost of Treatment of Acetaminophen Poisoning?. . 2015; 125 - 127.
Vancouver ÇEBİÇCİ H,KİLCİ A,Bol O,GÜRBÜZ S,VURAL A,Karaca B,CAKIR I Does Money Spent on Measuring Blood Levels of Acetaminophen Reduce the Cost of Treatment of Acetaminophen Poisoning?. . 2015; 125 - 127.
IEEE ÇEBİÇCİ H,KİLCİ A,Bol O,GÜRBÜZ S,VURAL A,Karaca B,CAKIR I "Does Money Spent on Measuring Blood Levels of Acetaminophen Reduce the Cost of Treatment of Acetaminophen Poisoning?." , ss.125 - 127, 2015.
ISNAD ÇEBİÇCİ, Hüseyin vd. "Does Money Spent on Measuring Blood Levels of Acetaminophen Reduce the Cost of Treatment of Acetaminophen Poisoning?". (2015), 125-127.
APA ÇEBİÇCİ H, KİLCİ A, Bol O, GÜRBÜZ S, VURAL A, Karaca B, CAKIR I (2015). Does Money Spent on Measuring Blood Levels of Acetaminophen Reduce the Cost of Treatment of Acetaminophen Poisoning?. Erciyes Medical Journal, 37(4), 125 - 127.
Chicago ÇEBİÇCİ Hüseyin,KİLCİ Ali İhsan,Bol Oğuzhan,GÜRBÜZ SÜKRÜ,VURAL Abdussamed,Karaca Bahadır,CAKIR Isil Does Money Spent on Measuring Blood Levels of Acetaminophen Reduce the Cost of Treatment of Acetaminophen Poisoning?. Erciyes Medical Journal 37, no.4 (2015): 125 - 127.
MLA ÇEBİÇCİ Hüseyin,KİLCİ Ali İhsan,Bol Oğuzhan,GÜRBÜZ SÜKRÜ,VURAL Abdussamed,Karaca Bahadır,CAKIR Isil Does Money Spent on Measuring Blood Levels of Acetaminophen Reduce the Cost of Treatment of Acetaminophen Poisoning?. Erciyes Medical Journal, vol.37, no.4, 2015, ss.125 - 127.
AMA ÇEBİÇCİ H,KİLCİ A,Bol O,GÜRBÜZ S,VURAL A,Karaca B,CAKIR I Does Money Spent on Measuring Blood Levels of Acetaminophen Reduce the Cost of Treatment of Acetaminophen Poisoning?. Erciyes Medical Journal. 2015; 37(4): 125 - 127.
Vancouver ÇEBİÇCİ H,KİLCİ A,Bol O,GÜRBÜZ S,VURAL A,Karaca B,CAKIR I Does Money Spent on Measuring Blood Levels of Acetaminophen Reduce the Cost of Treatment of Acetaminophen Poisoning?. Erciyes Medical Journal. 2015; 37(4): 125 - 127.
IEEE ÇEBİÇCİ H,KİLCİ A,Bol O,GÜRBÜZ S,VURAL A,Karaca B,CAKIR I "Does Money Spent on Measuring Blood Levels of Acetaminophen Reduce the Cost of Treatment of Acetaminophen Poisoning?." Erciyes Medical Journal, 37, ss.125 - 127, 2015.
ISNAD ÇEBİÇCİ, Hüseyin vd. "Does Money Spent on Measuring Blood Levels of Acetaminophen Reduce the Cost of Treatment of Acetaminophen Poisoning?". Erciyes Medical Journal 37/4 (2015), 125-127.