A Flow Cytometric Scoring System in the Diagnosis of Mantle Cell Lymphoma

Objective: Our aim was to evaluate the contribution of flow cytometry (FC) analysis in patients with a histopathological diagnosis of mantle cell lymphoma (MCL) and to develop a reliable scoring system.Materials and Methods: We assessed the results of FC analysis in peripheral blood or bone marrow samples of 36 patients diagnosed with MCL by histopathological evaluation. Multivariate analysis identified 5 variables associated with MCL: CD23 negativity, CD5/19 common positivity, CD20/22 common bright positivity, FMC7 positivity, and clonal sIg bright positivity. A 5-point scoring system was devised using these parameters.Results: Twenty-five patients (69.4%) scored 5 points, 8 (22.2%) scored 4 points, and 3 (8.4%) scored 3 points. The diagnosis of MCL was confirmed by FC immunophenotyping in 91.6% of the patients.Conclusion: Our results suggest that a quintet diagnostic scoring system, which is considered to be reliable in the diagnosis of MCL, could make a substantial contribution to diagnosis and should be more widely introduced in practice.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Keklik M, KÖKER M, Korkmaz S, ŞIVGIN S, Kaynar L, ÇAMLICA D, Eser B, ÇETİN M, ÜNAL A (2016). A Flow Cytometric Scoring System in the Diagnosis of Mantle Cell Lymphoma. , 25 - 28.
Chicago	Keklik Muzaffer,KÖKER M. Yavuz,Korkmaz Serdal,ŞIVGIN Serdar,Kaynar Leylagul,ÇAMLICA Demet,Eser Bülent,ÇETİN Mustafa,ÜNAL Ali A Flow Cytometric Scoring System in the Diagnosis of Mantle Cell Lymphoma. (2016): 25 - 28.
MLA	Keklik Muzaffer,KÖKER M. Yavuz,Korkmaz Serdal,ŞIVGIN Serdar,Kaynar Leylagul,ÇAMLICA Demet,Eser Bülent,ÇETİN Mustafa,ÜNAL Ali A Flow Cytometric Scoring System in the Diagnosis of Mantle Cell Lymphoma. , 2016, ss.25 - 28.
AMA	Keklik M,KÖKER M,Korkmaz S,ŞIVGIN S,Kaynar L,ÇAMLICA D,Eser B,ÇETİN M,ÜNAL A A Flow Cytometric Scoring System in the Diagnosis of Mantle Cell Lymphoma. . 2016; 25 - 28.
Vancouver	Keklik M,KÖKER M,Korkmaz S,ŞIVGIN S,Kaynar L,ÇAMLICA D,Eser B,ÇETİN M,ÜNAL A A Flow Cytometric Scoring System in the Diagnosis of Mantle Cell Lymphoma. . 2016; 25 - 28.
IEEE	Keklik M,KÖKER M,Korkmaz S,ŞIVGIN S,Kaynar L,ÇAMLICA D,Eser B,ÇETİN M,ÜNAL A "A Flow Cytometric Scoring System in the Diagnosis of Mantle Cell Lymphoma." , ss.25 - 28, 2016.
ISNAD	Keklik, Muzaffer vd. "A Flow Cytometric Scoring System in the Diagnosis of Mantle Cell Lymphoma". (2016), 25-28.

APA	Keklik M, KÖKER M, Korkmaz S, ŞIVGIN S, Kaynar L, ÇAMLICA D, Eser B, ÇETİN M, ÜNAL A (2016). A Flow Cytometric Scoring System in the Diagnosis of Mantle Cell Lymphoma. Erciyes Medical Journal, 38(1), 25 - 28.
Chicago	Keklik Muzaffer,KÖKER M. Yavuz,Korkmaz Serdal,ŞIVGIN Serdar,Kaynar Leylagul,ÇAMLICA Demet,Eser Bülent,ÇETİN Mustafa,ÜNAL Ali A Flow Cytometric Scoring System in the Diagnosis of Mantle Cell Lymphoma. Erciyes Medical Journal 38, no.1 (2016): 25 - 28.
MLA	Keklik Muzaffer,KÖKER M. Yavuz,Korkmaz Serdal,ŞIVGIN Serdar,Kaynar Leylagul,ÇAMLICA Demet,Eser Bülent,ÇETİN Mustafa,ÜNAL Ali A Flow Cytometric Scoring System in the Diagnosis of Mantle Cell Lymphoma. Erciyes Medical Journal, vol.38, no.1, 2016, ss.25 - 28.
AMA	Keklik M,KÖKER M,Korkmaz S,ŞIVGIN S,Kaynar L,ÇAMLICA D,Eser B,ÇETİN M,ÜNAL A A Flow Cytometric Scoring System in the Diagnosis of Mantle Cell Lymphoma. Erciyes Medical Journal. 2016; 38(1): 25 - 28.
Vancouver	Keklik M,KÖKER M,Korkmaz S,ŞIVGIN S,Kaynar L,ÇAMLICA D,Eser B,ÇETİN M,ÜNAL A A Flow Cytometric Scoring System in the Diagnosis of Mantle Cell Lymphoma. Erciyes Medical Journal. 2016; 38(1): 25 - 28.
IEEE	Keklik M,KÖKER M,Korkmaz S,ŞIVGIN S,Kaynar L,ÇAMLICA D,Eser B,ÇETİN M,ÜNAL A "A Flow Cytometric Scoring System in the Diagnosis of Mantle Cell Lymphoma." Erciyes Medical Journal, 38, ss.25 - 28, 2016.
ISNAD	Keklik, Muzaffer vd. "A Flow Cytometric Scoring System in the Diagnosis of Mantle Cell Lymphoma". Erciyes Medical Journal 38/1 (2016), 25-28.