The Role of p16, p21, p27, p53 and Ki-67 Expression in the Differential Diagnosis of Cutaneous Squamous Cell Carcinomas and Keratoacanthomas: An Immunohistochemical Study

bagci, pelin; GÜÇER, Hasan; BEDİR, Recep; ŞEHİTOĞLU, İbrahim; YURDAKUL, Cüneyt; ÜSTÜNER, PELİN DOĞA

The Role of p16, p21, p27, p53 and Ki-67 Expression in the Differential Diagnosis of Cutaneous Squamous Cell Carcinomas and Keratoacanthomas: An Immunohistochemical Study

Recep BEDİR, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Rize, Türkiye)

Hasan GÜÇER, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Rize, Türkiye)

İbrahim ŞEHİTOĞLU, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Rize, Türkiye)

Cüneyt YURDAKUL, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Rize, Türkiye)

Pelin BAĞCI, (Marmara Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, İstanbul, Türkiye)

PELİN DOĞA ÜSTÜNER (Rize Devlet Hastanesi, Dermatoloji Kliniği, Rize, Türkiye)

Balkan Medical Journal

3 1

Yıl: 2016 Cilt: 33 Sayı: 2 Sayfa Aralığı: 121 - 127 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

The Role of p16, p21, p27, p53 and Ki-67 Expression in the Differential Diagnosis of Cutaneous Squamous Cell Carcinomas and Keratoacanthomas: An Immunohistochemical Study

Öz:

Background: Distinguishing squamous cell carcinoma (SCC) from keratoacanthoma (KA) by histopathological features may not be sufficient for a differential diagnosis, as KAs may, in some cases, imitate well-differentiated SCCs. Aims: In this study, we investigated whether the expression of the p16, p21, p27, p53 genes and a Ki-67 proliferation index are useful in distinguishing between these two tumors. Study Design: Cross-sectional study. Methods: Immunohistochemistry was used to investigate the expression of the p16, p21, p27, p53 genes and the Ki-67 proliferation index was investigated in well-differentiated SCC with KA-like features (n=40) and KA (n=30). Results: The results of all of the examined markers, except for p27 (p16, p21, p53, and Ki-67) were found to be significantly different between the SCC and KA samples (p<0.05). Conclusion: In well-differentiated SCC with KA-like features and KA cases where the differential diagnosis is difficult from a histopathological perspective, the use of p16, p21, p53 expression and a Ki-67 proliferation index can be useful for the differential diagnosis of SCCs and KAs.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	BEDİR R, GÜÇER H, ŞEHİTOĞLU İ, YURDAKUL C, bagci p, ÜSTÜNER P (2016). The Role of p16, p21, p27, p53 and Ki-67 Expression in the Differential Diagnosis of Cutaneous Squamous Cell Carcinomas and Keratoacanthomas: An Immunohistochemical Study. , 121 - 127.
Chicago	BEDİR Recep,GÜÇER Hasan,ŞEHİTOĞLU İbrahim,YURDAKUL Cüneyt,bagci pelin,ÜSTÜNER PELİN DOĞA The Role of p16, p21, p27, p53 and Ki-67 Expression in the Differential Diagnosis of Cutaneous Squamous Cell Carcinomas and Keratoacanthomas: An Immunohistochemical Study. (2016): 121 - 127.
MLA	BEDİR Recep,GÜÇER Hasan,ŞEHİTOĞLU İbrahim,YURDAKUL Cüneyt,bagci pelin,ÜSTÜNER PELİN DOĞA The Role of p16, p21, p27, p53 and Ki-67 Expression in the Differential Diagnosis of Cutaneous Squamous Cell Carcinomas and Keratoacanthomas: An Immunohistochemical Study. , 2016, ss.121 - 127.
AMA	BEDİR R,GÜÇER H,ŞEHİTOĞLU İ,YURDAKUL C,bagci p,ÜSTÜNER P The Role of p16, p21, p27, p53 and Ki-67 Expression in the Differential Diagnosis of Cutaneous Squamous Cell Carcinomas and Keratoacanthomas: An Immunohistochemical Study. . 2016; 121 - 127.
Vancouver	BEDİR R,GÜÇER H,ŞEHİTOĞLU İ,YURDAKUL C,bagci p,ÜSTÜNER P The Role of p16, p21, p27, p53 and Ki-67 Expression in the Differential Diagnosis of Cutaneous Squamous Cell Carcinomas and Keratoacanthomas: An Immunohistochemical Study. . 2016; 121 - 127.
IEEE	BEDİR R,GÜÇER H,ŞEHİTOĞLU İ,YURDAKUL C,bagci p,ÜSTÜNER P "The Role of p16, p21, p27, p53 and Ki-67 Expression in the Differential Diagnosis of Cutaneous Squamous Cell Carcinomas and Keratoacanthomas: An Immunohistochemical Study." , ss.121 - 127, 2016.
ISNAD	BEDİR, Recep vd. "The Role of p16, p21, p27, p53 and Ki-67 Expression in the Differential Diagnosis of Cutaneous Squamous Cell Carcinomas and Keratoacanthomas: An Immunohistochemical Study". (2016), 121-127.

APA	BEDİR R, GÜÇER H, ŞEHİTOĞLU İ, YURDAKUL C, bagci p, ÜSTÜNER P (2016). The Role of p16, p21, p27, p53 and Ki-67 Expression in the Differential Diagnosis of Cutaneous Squamous Cell Carcinomas and Keratoacanthomas: An Immunohistochemical Study. Balkan Medical Journal, 33(2), 121 - 127.
Chicago	BEDİR Recep,GÜÇER Hasan,ŞEHİTOĞLU İbrahim,YURDAKUL Cüneyt,bagci pelin,ÜSTÜNER PELİN DOĞA The Role of p16, p21, p27, p53 and Ki-67 Expression in the Differential Diagnosis of Cutaneous Squamous Cell Carcinomas and Keratoacanthomas: An Immunohistochemical Study. Balkan Medical Journal 33, no.2 (2016): 121 - 127.
MLA	BEDİR Recep,GÜÇER Hasan,ŞEHİTOĞLU İbrahim,YURDAKUL Cüneyt,bagci pelin,ÜSTÜNER PELİN DOĞA The Role of p16, p21, p27, p53 and Ki-67 Expression in the Differential Diagnosis of Cutaneous Squamous Cell Carcinomas and Keratoacanthomas: An Immunohistochemical Study. Balkan Medical Journal, vol.33, no.2, 2016, ss.121 - 127.
AMA	BEDİR R,GÜÇER H,ŞEHİTOĞLU İ,YURDAKUL C,bagci p,ÜSTÜNER P The Role of p16, p21, p27, p53 and Ki-67 Expression in the Differential Diagnosis of Cutaneous Squamous Cell Carcinomas and Keratoacanthomas: An Immunohistochemical Study. Balkan Medical Journal. 2016; 33(2): 121 - 127.
Vancouver	BEDİR R,GÜÇER H,ŞEHİTOĞLU İ,YURDAKUL C,bagci p,ÜSTÜNER P The Role of p16, p21, p27, p53 and Ki-67 Expression in the Differential Diagnosis of Cutaneous Squamous Cell Carcinomas and Keratoacanthomas: An Immunohistochemical Study. Balkan Medical Journal. 2016; 33(2): 121 - 127.
IEEE	BEDİR R,GÜÇER H,ŞEHİTOĞLU İ,YURDAKUL C,bagci p,ÜSTÜNER P "The Role of p16, p21, p27, p53 and Ki-67 Expression in the Differential Diagnosis of Cutaneous Squamous Cell Carcinomas and Keratoacanthomas: An Immunohistochemical Study." Balkan Medical Journal, 33, ss.121 - 127, 2016.
ISNAD	BEDİR, Recep vd. "The Role of p16, p21, p27, p53 and Ki-67 Expression in the Differential Diagnosis of Cutaneous Squamous Cell Carcinomas and Keratoacanthomas: An Immunohistochemical Study". Balkan Medical Journal 33/2 (2016), 121-127.