How Does Folic Acid Supplementation Affect Serum Folate Concentrations in Pregnant Turkish Women?

OZER, SERDAR; KÖSTÜ, Bülent; PEKTAŞ KANAT, Mine; ERCAN, Önder; ÖZER, Alev

How Does Folic Acid Supplementation Affect Serum Folate Concentrations in Pregnant Turkish Women?

Alev ÖZER, (Sütçü İmam Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Kahramanmaraş, Türkiye)

Serdar ÖZER, (Pazarcık Devlet Hastanesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Kahramanmaraş, Türkiye)

Mine PEKTAŞ KANAT, (Afyon Kocatepe Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Afyon, Türkiye)

Bülent KÖSTÜ, (Sütçü İmam Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Kahramanmaraş, Türkiye)

Önder ERCAN (Sütçü İmam Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Kahramanmaraş, Türkiye)

Journal of Clinical and Analytical Medicine

2 0

Yıl: 2016 Cilt: 7 Sayı: 4 Sayfa Aralığı: 538 - 541 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

How Does Folic Acid Supplementation Affect Serum Folate Concentrations in Pregnant Turkish Women?

Öz:

Amaç: Folik asit takviyesinin Türk toplumunda gebelerin serum folat düzeyleri üzerine etkisinin belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Toplam 397 hastanın klinik kayıtları retrospektif olarak incelendi. Folik asit takviyesi yapılıp yapılmamasına göre hastalar 2 gruba ayrıldı: Grup 1 (n=294), gebelikten önce veya gebelik sırasında folik asit takviyesi kullanmamış hastalar, Grup 2 (n=103) gebelik öncesinden başlayarak düzenli olarak hergün 400 mcg kullanan hastalar. Gruplar demografik ve laboratuar veriler açısından karşılaştırıldı. Bulgular: Gebelik öncesi ve gebelik sırasındaki hemoglobin, serum kalsiyum ve serum folat seviyeleri her 2 grupta benzer olarak saptandı (sırasıyla p=0.544, p=0.549, p=0.289, p=0.299, p=0.072 ve p=0.061). Grup 1 için gebelik öncesi ve gebelik sırasındaki folat konsantrasyonları arasında istatiksel olarak anlamlı fark saptanmadı (p=0.059). Grup 2 için gebelik öncesinde ve gebelik sırasında folat konsantrasyonları istatistiksel olarak benzerdi (p=0.057). Molar gebelik, intrauterin ölüm, nöral tüp defekti, ventriküler septal defect, fetal büyüme kısıtlılığı, preeklampsi, preterm doğum, doğum ağırlığı, yenidoğan yoğun bakım gereksinimi, 1. ve 5. dakika Apgar skorları gibi perinatal sonuçlar bakımından gruplar benzer olarak saptandı (sırasıyla p=0.760, p=0.576, p=0.382, p=0.553, p=0.452, p=0.940, p=0.683, p=0.855, p=0.710, p=0.910 ve p=0.924). Tartışma: Mevcut çalışmanın bulguları, gebe kadınlarda sadece günlük beslenme alışkanlıklarıyla serum folat düzeylerinin 4.5 ng/ml üzerinde tutulabildiğini düşündürmektedir.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Folik Asit Takviyesi Türk Toplumunda Gebelerde Serum Folat Düzeyini Nasıl Etkilemektedir?

Öz:

Aim: To determine the effect of the use of folic acid supplementation on serum folate levels in Turkish pregnant women. Material and Method: Clinical records of a total of 397 patients were retrospectively examined. The patients were recruited into 2 groups based on folic acid supplementation. Group 1 included 294 women who did not take any folic acid tablets before or during pregnancy and Group 2 consisted of 103 women who regularly took 400 mcg of folic acid daily, starting from the preconception period. Both groups were compared with respect to demographic and biochemical characteristics. Results: The patients in Group 1 and 2 had statistically similar pre-pregnancy and pregnancy hemoglobin, pre-pregnancy and pregnancy serum calcium, and pre-pregnancy and pregnancy serum folate concentrations (p=0.544, p=0.549, p=0.289, p=0.299, p=0.072, and p=0.061 respectively). No statistically significant difference was determined between pre-pregnancy and pregnancy folate concentrations in Group 1 (p=0.059). Pre-pregnancy and pregnancy folate concentrations were statistically similar in Group 2 (p=0.057). Both study groups were determined as statistically similar with respect to perinatal outcomes, including molar pregnancy, intrauterine demise, neural tube defects, ventricular septal defect, fetal growth restriction, preeclampsia, preterm birth, birth weight, neonatal intensive care unit admission, and 1st minute and 5th minute Apgar scores (p=0.760, p=0.576, p=0.382, p=0.553, p=0.452, p=0.940, p=0.683, p=0.855, p=0.710, p=0.910, and p=0.924 respectively). Discussion: Based on the findings of the present study, it may be considered that serum folate concentrations in pregnant women can be maintained by dietary intake alone of over 4.5 ng/ml.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÖZER A, OZER S, PEKTAŞ KANAT M, KÖSTÜ B, ERCAN Ö (2016). How Does Folic Acid Supplementation Affect Serum Folate Concentrations in Pregnant Turkish Women?. , 538 - 541.
Chicago	ÖZER Alev,OZER SERDAR,PEKTAŞ KANAT Mine,KÖSTÜ Bülent,ERCAN Önder How Does Folic Acid Supplementation Affect Serum Folate Concentrations in Pregnant Turkish Women?. (2016): 538 - 541.
MLA	ÖZER Alev,OZER SERDAR,PEKTAŞ KANAT Mine,KÖSTÜ Bülent,ERCAN Önder How Does Folic Acid Supplementation Affect Serum Folate Concentrations in Pregnant Turkish Women?. , 2016, ss.538 - 541.
AMA	ÖZER A,OZER S,PEKTAŞ KANAT M,KÖSTÜ B,ERCAN Ö How Does Folic Acid Supplementation Affect Serum Folate Concentrations in Pregnant Turkish Women?. . 2016; 538 - 541.
Vancouver	ÖZER A,OZER S,PEKTAŞ KANAT M,KÖSTÜ B,ERCAN Ö How Does Folic Acid Supplementation Affect Serum Folate Concentrations in Pregnant Turkish Women?. . 2016; 538 - 541.
IEEE	ÖZER A,OZER S,PEKTAŞ KANAT M,KÖSTÜ B,ERCAN Ö "How Does Folic Acid Supplementation Affect Serum Folate Concentrations in Pregnant Turkish Women?." , ss.538 - 541, 2016.
ISNAD	ÖZER, Alev vd. "How Does Folic Acid Supplementation Affect Serum Folate Concentrations in Pregnant Turkish Women?". (2016), 538-541.

APA	ÖZER A, OZER S, PEKTAŞ KANAT M, KÖSTÜ B, ERCAN Ö (2016). How Does Folic Acid Supplementation Affect Serum Folate Concentrations in Pregnant Turkish Women?. Journal of Clinical and Analytical Medicine, 7(4), 538 - 541.
Chicago	ÖZER Alev,OZER SERDAR,PEKTAŞ KANAT Mine,KÖSTÜ Bülent,ERCAN Önder How Does Folic Acid Supplementation Affect Serum Folate Concentrations in Pregnant Turkish Women?. Journal of Clinical and Analytical Medicine 7, no.4 (2016): 538 - 541.
MLA	ÖZER Alev,OZER SERDAR,PEKTAŞ KANAT Mine,KÖSTÜ Bülent,ERCAN Önder How Does Folic Acid Supplementation Affect Serum Folate Concentrations in Pregnant Turkish Women?. Journal of Clinical and Analytical Medicine, vol.7, no.4, 2016, ss.538 - 541.
AMA	ÖZER A,OZER S,PEKTAŞ KANAT M,KÖSTÜ B,ERCAN Ö How Does Folic Acid Supplementation Affect Serum Folate Concentrations in Pregnant Turkish Women?. Journal of Clinical and Analytical Medicine. 2016; 7(4): 538 - 541.
Vancouver	ÖZER A,OZER S,PEKTAŞ KANAT M,KÖSTÜ B,ERCAN Ö How Does Folic Acid Supplementation Affect Serum Folate Concentrations in Pregnant Turkish Women?. Journal of Clinical and Analytical Medicine. 2016; 7(4): 538 - 541.
IEEE	ÖZER A,OZER S,PEKTAŞ KANAT M,KÖSTÜ B,ERCAN Ö "How Does Folic Acid Supplementation Affect Serum Folate Concentrations in Pregnant Turkish Women?." Journal of Clinical and Analytical Medicine, 7, ss.538 - 541, 2016.
ISNAD	ÖZER, Alev vd. "How Does Folic Acid Supplementation Affect Serum Folate Concentrations in Pregnant Turkish Women?". Journal of Clinical and Analytical Medicine 7/4 (2016), 538-541.