The Effect of Indoor Environmental Characteristics on the Detection of House Dust Mite Der p2 and Der f2 in Asthmatics

Ceylan, Emel; KARADAĞ, FİSUN; ÇİLDAĞ, Orhan; Kırdar, Sevin; DEMİRTAŞ, Nimet

The Effect of Indoor Environmental Characteristics on the Detection of House Dust Mite Der p2 and Der f2 in Asthmatics

Nimet DEMİRTAŞ, (Atatürk Devlet Hastanesi, Göğüs Hastalıkları Anabilim Dalı, Aydın, Türkiye)

Emel CEYLAN, (Adnan Menderes Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Aydın, Türkiye)

Sevin KIRDAR, (Adnan Menderes Üniversitesi, Tıp Fakültesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dalı, Aydın, Türkiye)

Fisun KARADAĞ, (Adnan Menderes Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Aydın, Türkiye)

Orhan ÇİLDAĞ (Adnan Menderes Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Aydın, Türkiye)

Meandros Medical And Dental Journal

2 0

Yıl: 2016 Cilt: 17 Sayı: 3 Sayfa Aralığı: 129 - 137 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The Effect of Indoor Environmental Characteristics on the Detection of House Dust Mite Der p2 and Der f2 in Asthmatics

Öz:

Amaç: Ev tozunda bulunan akarlar, astımda allerjik duyarlılığın gelişmesinde ve hastalık kontrolünü bozan tetikleyici olarak önemli rol oynar. Bu çalışmanın amacı, stabil astımlılarda ev tozu akarı allerjen yoğunluğunun ev içi ortam özellikleriyle ilişkisini incelemektir. Gereç ve Yöntemler: Çalışma süresi içerisinde polikliniğe başvuran 97 ardışık stabil astım hastası, demografik özellikleri ve ev içi ortam değerlendirmesi için yüz yüze uygulanan standart bir anket yardımıyla sorgulandı. Evlerinden ev tozu örnekleri toplandı ve Dermatophagoides farinae (Der f2) ve Dermatophagoides pteronyssinus (Der p2) düzeyleri Enzyme-linked immunosorbent assay (ELISA) yöntemiyle kantitatif olarak ölçüldü. Bulgular: Çalışma grubumuzun %54,1'inin toz örneklerinde ölçülebilir düzeyde antijen saptandı. Evde gözlenebilir küf ve rutubet olduğunda, antijen saptanma oranı daha yüksekti. Antijen saptanan evlerde yaşayan kişi sayısı, antijen saptanmayan evlerde yaşayan kişi sayısından daha yüksekti. Ev içi ortam özellikleri lojistik regresyon analizi ile değerlendirildiğinde evde yaşayan kişi sayısının 4 ve üzerinde olmasının akar allerjeni saptanmasına etkili faktör olarak saptandı. Der p2 ve Der f2 antijen saptanması için Odds oranı 5,29 olarak saptandı (güven aralığı 2,18-12,86) (p<0,0001). Sonuç: Kantitatif ELISA yöntemi ile olguların yarıdan fazlasında ev tozu örneğinde akar allerjeni tespit edildi. Bulgularımız, ev içi ortam özellikleri ile saptanan allerjen konsantrasyonu arasında ilişki olmadığını düşündürmüştür.

Anahtar Kelime:

Konular: Diş Hekimliği

Astımlı Hastalarda Ev İçi Ortam Özelliklerinin Ev Tozu Akar Allerjeni Der p2 ve Der f2 Saptanmasına Etkisi

Öz:

Objective: Mites in house dust play a prominent role in the development of allergic sensitization and as a triggering factor that impairs disease control in asthma. The aim of the study was to determine whether the concentration of house dust mite allergens is associated with indoor conditions in stable asthmatics.Materials and Methods: During the study period, a total of 97 asthmatic patients were queried with a standard survey for their demographical characteristics and living environment. House dust samples from their houses were collected to quantitatively measure Dermatophagoides farinae (Der f2) and Dermatophagoides pteronyssinus (Der p2) levels by using the Enzyme-linked immunosorbent assay (ELISA) method. Results: Using the quantitative ELISA method, measurable levels of mite allergens were found in 54.1% of the houses. Higher antigen detection rate was found in houses with visible mould and in those with moisture. The number of household was found to be significantly higher in houses with antigens than in those without antigens. When the indoor characteristics were evaluated by logistic regression analysis, larger number of household (>=4) was found to be a significant risk factor for the presence of mite allergens. The odds ratio for detecting Der p2 and Der f2 antigen was found to be 5.29 (confidence interval 2.18-12.86) (p<0.001).Conclusion: Mite allergen was detected in the house dusts of more than half of the cases by using quantitative ELISA method. Our results did not found any association between concentrations of allergens and indoor characteristics.

Anahtar Kelime:

Konular: Diş Hekimliği

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	DEMİRTAŞ N, Ceylan E, Kırdar S, KARADAĞ F, ÇİLDAĞ O (2016). The Effect of Indoor Environmental Characteristics on the Detection of House Dust Mite Der p2 and Der f2 in Asthmatics. , 129 - 137.
Chicago	DEMİRTAŞ Nimet,Ceylan Emel,Kırdar Sevin,KARADAĞ FİSUN,ÇİLDAĞ Orhan The Effect of Indoor Environmental Characteristics on the Detection of House Dust Mite Der p2 and Der f2 in Asthmatics. (2016): 129 - 137.
MLA	DEMİRTAŞ Nimet,Ceylan Emel,Kırdar Sevin,KARADAĞ FİSUN,ÇİLDAĞ Orhan The Effect of Indoor Environmental Characteristics on the Detection of House Dust Mite Der p2 and Der f2 in Asthmatics. , 2016, ss.129 - 137.
AMA	DEMİRTAŞ N,Ceylan E,Kırdar S,KARADAĞ F,ÇİLDAĞ O The Effect of Indoor Environmental Characteristics on the Detection of House Dust Mite Der p2 and Der f2 in Asthmatics. . 2016; 129 - 137.
Vancouver	DEMİRTAŞ N,Ceylan E,Kırdar S,KARADAĞ F,ÇİLDAĞ O The Effect of Indoor Environmental Characteristics on the Detection of House Dust Mite Der p2 and Der f2 in Asthmatics. . 2016; 129 - 137.
IEEE	DEMİRTAŞ N,Ceylan E,Kırdar S,KARADAĞ F,ÇİLDAĞ O "The Effect of Indoor Environmental Characteristics on the Detection of House Dust Mite Der p2 and Der f2 in Asthmatics." , ss.129 - 137, 2016.
ISNAD	DEMİRTAŞ, Nimet vd. "The Effect of Indoor Environmental Characteristics on the Detection of House Dust Mite Der p2 and Der f2 in Asthmatics". (2016), 129-137.

APA	DEMİRTAŞ N, Ceylan E, Kırdar S, KARADAĞ F, ÇİLDAĞ O (2016). The Effect of Indoor Environmental Characteristics on the Detection of House Dust Mite Der p2 and Der f2 in Asthmatics. Meandros Medical And Dental Journal, 17(3), 129 - 137.
Chicago	DEMİRTAŞ Nimet,Ceylan Emel,Kırdar Sevin,KARADAĞ FİSUN,ÇİLDAĞ Orhan The Effect of Indoor Environmental Characteristics on the Detection of House Dust Mite Der p2 and Der f2 in Asthmatics. Meandros Medical And Dental Journal 17, no.3 (2016): 129 - 137.
MLA	DEMİRTAŞ Nimet,Ceylan Emel,Kırdar Sevin,KARADAĞ FİSUN,ÇİLDAĞ Orhan The Effect of Indoor Environmental Characteristics on the Detection of House Dust Mite Der p2 and Der f2 in Asthmatics. Meandros Medical And Dental Journal, vol.17, no.3, 2016, ss.129 - 137.
AMA	DEMİRTAŞ N,Ceylan E,Kırdar S,KARADAĞ F,ÇİLDAĞ O The Effect of Indoor Environmental Characteristics on the Detection of House Dust Mite Der p2 and Der f2 in Asthmatics. Meandros Medical And Dental Journal. 2016; 17(3): 129 - 137.
Vancouver	DEMİRTAŞ N,Ceylan E,Kırdar S,KARADAĞ F,ÇİLDAĞ O The Effect of Indoor Environmental Characteristics on the Detection of House Dust Mite Der p2 and Der f2 in Asthmatics. Meandros Medical And Dental Journal. 2016; 17(3): 129 - 137.
IEEE	DEMİRTAŞ N,Ceylan E,Kırdar S,KARADAĞ F,ÇİLDAĞ O "The Effect of Indoor Environmental Characteristics on the Detection of House Dust Mite Der p2 and Der f2 in Asthmatics." Meandros Medical And Dental Journal, 17, ss.129 - 137, 2016.
ISNAD	DEMİRTAŞ, Nimet vd. "The Effect of Indoor Environmental Characteristics on the Detection of House Dust Mite Der p2 and Der f2 in Asthmatics". Meandros Medical And Dental Journal 17/3 (2016), 129-137.