Yıl: 2015 Cilt: 14 Sayı: 1 Sayfa Aralığı: 8 - 11 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

A Retrospective Evaluation of Patients Admitted to Emergency Departments with Pulmonary Thromboembolism

Öz:
Amaç: Pulmoner tromboemboli (PTE) tanısı ile acil servisimize başvuran hastaların klinik, radyolojik ve laboratuar bulgularını incelemek ve klinik skorlamaların tanıdaki etkinliğini değerlendirmektir. Gereç ve Yöntemler: Bu çalışmada üniversitemiz acil servisine başvuran 33 pulmoner tromboemboli olgusu geriye dönük olarak incelendi. Bulgular: Olguların yaş ortalaması 56,2±18,2 yıl idi. Kadın/erkek oranı ise 1,5 idi. Başvuru yakınmaları arasında en sık neden nefes darlığı (%51,5) idi. Risk faktörleri arasında ise çoğunluğu (%39,3) operasyona bağlı immobilizasyon hikayesi oluşturmaktaydı. Well's klinik skorlamasına göre olguların 29'u (%87,8) yüksek olasılıklı iken modifiye geneva skoruna göre ise olguların 18'i (%55,5) yüksek olasılıklı grupta idi. Well's skorunun yüksek olasılıklı PTE tahmin oranı Modifiye Geneva skoruna göre anlamlı oranda fazla idi (p=0,017). En sık görülen klinik bulgular taşipne (%69,6) ve taşikardi (%27,3) idi. 15 (%45,4) olguda patolojik akci- ğer grafisi vardı. Bilgisayarlı Tomografik (BT) Anjiografide PTE en sık bilateral pulmoner ana dallara yerleşim göstermekte idi. Yirmi yedi (%81,8) olguya standart düşük molekül ağırlıklı heparin+warfarin tedavisi uygulanırken 6 (%18,2) olguya ise doku plazminojen aktivatörü (tPA) tedavisi uygulanmıştı. Sonuç: PTE tanısında; klinik, laboratuar ve radyolojik bulguların birlikte değerlendirilmesi önemlidir. PTE kuşkusu olan hastaların klinik olasılık tahmininde Well's skorunun kullanımı tercih edilmelidir.
Anahtar Kelime:

Konular: Acil Tıp

Acil Servise Başvuran Pulmoner Tromboemboli Olgularının Retrospektif Olarak Değerlendirilmesi

Öz:
Aim: To examine the clinical, radiological, and laboratory findings of pulmonary thromboembolism (PTE) patients who were admitted to our emergency department and to evaluate the effectiveness of clinical diagnosis scores.Materials and Methods: We retrospectively evaluated 33 PTE patients who were referred to our emergency department. Results: The mean age of the patients was 56.2±18.2 years. The female:male ratio was 1.5. The most common cause of complaints was dyspnoea (51.5%). Risk factors in the majority (39.3%) included immobilisation due to surgery. According to the Wells clinical scoring system, 29 patients (87.8%) had a high probability of PTE; however, 18 of the patients (55.5%) had high probability of PTE according to the modified Geneva score. The estimated rate ratio of high probability of PTE with the Wells score was statistically significant compared with the estimate rate ration with the modified Geneva score (p=0.017). The most common clinical findings included tachypnoea (69.6%) and tachycardia (27.3%). Fifteen (45.4%) patients had pathologic chest X-ray findings. Computed tomographic (CT) angiography most often showed PTE placement of the bilateral pulmonary main branches. While standard low-molecular-weight heparin and warfarin treatment was administered to 27 (81.8%) patients, tissue plasminogen activator (tPA) treatment was administered to 6 (18.2%) patients. Conclusion: The evaluation of clinical, laboratory and radiological findings together in PTE diagnosis is important. It is preferable to use the Wells score for the estimation of clinical probability in patients with suspected PTE
Anahtar Kelime:

Konular: Acil Tıp
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • Editör: Umut S. Sayral BS. Pulmoner Tromboembolizm Tanı ve Tedavi Uzlaşı Raporu. Turk Thorac J 2010; 10: 7-46.
  • Palevsky HI, Kelley MA, Fishman AP, Pulmonary thromboembolik disease. In: Fishman AP, Elias JA, Fishman JA, Grippi MA (eds). Fishman's Pulmo- nary Diseas and Disorders. New York: International Edition McGraw Hill, 1998; 1297-329.
  • Guidelines on diagnosis and management of acute pulmonary embo- lism. Task Force on Pulmonary Embolism, European Society of Cardiolo- gy. Eur Heart J 2000; 21: 1301-36. [CrossRef]
  • Ogren M, Bergqvist D, Eriksson H, Lindblad B, Sternby NH. Prevalence and risk of pulmonary embolism in patients with intracardiac thrombo- sis: a population-based study of 23 796 consecutive autopsies. Eur Heart J 2005; 26: 1108-14. [CrossRef]
  • White RH. The epidemiology of venous thromboembolism. Circulation 2003; 107(Suppl 1): 4-8. [CrossRef]
  • Goldhaber SZ. Pulmonary Embolism. Lancet 2004; 363: 1295-305. [CrossRef]
  • Tapson VF. Acute pulmonary embolism. N Engl J Med 2008; 358: 1037-52. [CrossRef]
  • Anderson FA Jr, Wheeler HB, Goldberg RJ, Hosmer DW, Patwardhan NA, Jo- vanovic B, et al. A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study. Arch Intern Med 1991; 151: 933-8. [CrossRef]
  • Silverstein MD, Heit JA, Mohr DN, Petterson TM, O'Fallon WM, Melton LJ 3rd. Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med 1998; 158: 585-93. [CrossRef]
  • White RH, Zhou H, Romano PS. Incidence of idiopathic deep venous thrombosis and secondary thromboembolism among ethnic groups in California. Ann Intern Med 1998; 128: 737-40. [CrossRef]
  • Evliyagil H, Mutlu LC, Kızkın Ö, Günen H, Gülbaş G. Altmış üç pulmoner emboli olgusunun retrospektif değerkendrilmesi. Solunum Hastalıkları 2004; 15: 15-21.
  • Elias A, Colombier D, Victor G, Elias M, Arnaud C, Juchet H, et al. Diagnos- tic performance of complete lower limb venous ultrasound in patients with clinically suspected acute pulmonary embolism. Thromb Haemost 2004; 91: 187-95.
  • Cushman M, Tsai A, Heckbert SR, White R, Rosamund W, Enright P, et al. Incidence rates, case fatality, and recurrence rates of deep vein thrombo- sis and pulmonary embolus: the Longitudinal Investigation of Thrombo- embolism Etiology (LITE). Thromb Haemost 2001; 86(Suppl 1): OC2349.
  • Heit JA, O'Fallon WM, Petterson TM, Lohse CM, Silverstein MD, Mohr DN, et al. Relative impact of risk factors for deep vein thrombosis and pulmo- nary embolism: a population-based study. Arch Intern Med 2002; 162: 1245-8. [CrossRef]
  • Kıral N, Salepçi B, Özdoğan S, Tevetoğlu İ, Çağlayan B. Klinik olarak yüksek olasılıklı pulmoner emboli olgularımızın retrospektif analizi. Solunum Hastalıkları 2002; 13: 172-6.
  • Atikcan Ş, Atalay F, Turgut D, Ünsal E. Pulmoner trombo-emboli: 42 olgunun retrospektif değerlendirilmesi. Solunum Hastalıkları 2002; 13: 87-93.
  • Büller HR, Agnelli G, Hull RD, Hyers TM, Prins MH, Raskob GE. Antithrom- botic therapy for venous thromboembolic disease: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004; 126(3 Suppl): 401-28. [CrossRef]
  • The PIOPED investigators. Value of the ventilation/perfu-sion in acute pul- monary embolism: Results of the pros-pective investigation of pulmonary embolism diagnosis (PIOPED). JAMA 1990; 263: 2753-9. [CrossRef]
  • Perrier A, Bounaemeaux H. Cost-effective diagnosis of deep vein throm- bosis and pulmonary embolism. Thromb Haemost 2001; 86: 475.
  • Mayo JR, Remy-Jardin M, Müller NL, Remy J, Worsley DF, Hossein-Foucher C, et al. Pulmonary embolism: prospective comparison of spiral CT with venti- lation-perfusion scintigraphy. Radiology 1997; 205: 447-52. [CrossRef]
  • Trowbridge RL, Araoz PA, Gotway MB, Bailey RA, Auerbach AD. The effect of he- lical computed tomography on diagnostic and treatment strategies in patients with suspected pulmonary embolism. Am J Med 2004; 116: 84-90. [CrossRef]
  • Stein PD, Fowler SE, Goodman LR, Gottschalk A, Hales CA, Hull RD, et al. Multidetector computed tomography for acute pulmonary embolism. N Engl J Med 2006; 354: 2317-27. [CrossRef]
  • Powell T, Müller NL. Imaging of acute pulmonary thrombo-embolism: should spinal computed tomography replace the ventilation perfusion scan. Clin Chest Med 2003; 24: 29-38. [CrossRef] 11
APA GÜZEL A, YAVUZ Y, ŞİŞMAN B, DURAN L, ALTUNTAŞ M, MURAT N (2015). A Retrospective Evaluation of Patients Admitted to Emergency Departments with Pulmonary Thromboembolism. , 8 - 11.
Chicago GÜZEL Aygül,YAVUZ Yücel,ŞİŞMAN Bülent,DURAN Latif,ALTUNTAŞ Mehmet,MURAT NACİ A Retrospective Evaluation of Patients Admitted to Emergency Departments with Pulmonary Thromboembolism. (2015): 8 - 11.
MLA GÜZEL Aygül,YAVUZ Yücel,ŞİŞMAN Bülent,DURAN Latif,ALTUNTAŞ Mehmet,MURAT NACİ A Retrospective Evaluation of Patients Admitted to Emergency Departments with Pulmonary Thromboembolism. , 2015, ss.8 - 11.
AMA GÜZEL A,YAVUZ Y,ŞİŞMAN B,DURAN L,ALTUNTAŞ M,MURAT N A Retrospective Evaluation of Patients Admitted to Emergency Departments with Pulmonary Thromboembolism. . 2015; 8 - 11.
Vancouver GÜZEL A,YAVUZ Y,ŞİŞMAN B,DURAN L,ALTUNTAŞ M,MURAT N A Retrospective Evaluation of Patients Admitted to Emergency Departments with Pulmonary Thromboembolism. . 2015; 8 - 11.
IEEE GÜZEL A,YAVUZ Y,ŞİŞMAN B,DURAN L,ALTUNTAŞ M,MURAT N "A Retrospective Evaluation of Patients Admitted to Emergency Departments with Pulmonary Thromboembolism." , ss.8 - 11, 2015.
ISNAD GÜZEL, Aygül vd. "A Retrospective Evaluation of Patients Admitted to Emergency Departments with Pulmonary Thromboembolism". (2015), 8-11.
APA GÜZEL A, YAVUZ Y, ŞİŞMAN B, DURAN L, ALTUNTAŞ M, MURAT N (2015). A Retrospective Evaluation of Patients Admitted to Emergency Departments with Pulmonary Thromboembolism. Eurasian Journal of Emergency Medicine, 14(1), 8 - 11.
Chicago GÜZEL Aygül,YAVUZ Yücel,ŞİŞMAN Bülent,DURAN Latif,ALTUNTAŞ Mehmet,MURAT NACİ A Retrospective Evaluation of Patients Admitted to Emergency Departments with Pulmonary Thromboembolism. Eurasian Journal of Emergency Medicine 14, no.1 (2015): 8 - 11.
MLA GÜZEL Aygül,YAVUZ Yücel,ŞİŞMAN Bülent,DURAN Latif,ALTUNTAŞ Mehmet,MURAT NACİ A Retrospective Evaluation of Patients Admitted to Emergency Departments with Pulmonary Thromboembolism. Eurasian Journal of Emergency Medicine, vol.14, no.1, 2015, ss.8 - 11.
AMA GÜZEL A,YAVUZ Y,ŞİŞMAN B,DURAN L,ALTUNTAŞ M,MURAT N A Retrospective Evaluation of Patients Admitted to Emergency Departments with Pulmonary Thromboembolism. Eurasian Journal of Emergency Medicine. 2015; 14(1): 8 - 11.
Vancouver GÜZEL A,YAVUZ Y,ŞİŞMAN B,DURAN L,ALTUNTAŞ M,MURAT N A Retrospective Evaluation of Patients Admitted to Emergency Departments with Pulmonary Thromboembolism. Eurasian Journal of Emergency Medicine. 2015; 14(1): 8 - 11.
IEEE GÜZEL A,YAVUZ Y,ŞİŞMAN B,DURAN L,ALTUNTAŞ M,MURAT N "A Retrospective Evaluation of Patients Admitted to Emergency Departments with Pulmonary Thromboembolism." Eurasian Journal of Emergency Medicine, 14, ss.8 - 11, 2015.
ISNAD GÜZEL, Aygül vd. "A Retrospective Evaluation of Patients Admitted to Emergency Departments with Pulmonary Thromboembolism". Eurasian Journal of Emergency Medicine 14/1 (2015), 8-11.