Primary carcinoma of the gallbladder is the fifth most common tumor of the gastrointestinal tract. It is usually detected by directly spreading to adjacent tissues, lymphatic spreading to regional lymphnodes or dissemine metastases. A 74year-old female patient underwent cholecystectomy because of symptomatic acalculous cholecystitis. Postoperative pathologic examination of the specimen led to a diagnosis of adeno carcinoma in the wall of gallbladder. After diagnosis, this patient underwent a second operation, which was a radical cholecystectomy. Because complaints of the patient and the physical findings are nonspesific, the gold standart in diagnosis and treatment is to be always suspicious about it. In this study, our aim was to discuss adenocarcinoma in gall bladder which is encountered rarely.