Glutathione-S-Transferase Variants are not Associated With Increased Carotid Intima-Media Thickness in Turkish Familial Mediterranean Fever Patients

Bağcı, Gökhan; CANDAN, Ferhan; Hüzmeli, can; GÜRBÜZ, Özlem; BAĞCI, Binnur

Glutathione-S-Transferase Variants are not Associated With Increased Carotid Intima-Media Thickness in Turkish Familial Mediterranean Fever Patients

Özlem GÜRBÜZ, (Cumhuriyet Üniversitesi Tıp Fakültesi, Sivas, Türkiye)

Binnur BAĞCI, (Boş)

Can HÜZMELİ, (Boş)

Gökhan BAĞCI, (Boş)

Ferhan CANDAN (Boş)

Archives of Rheumatology

2 0

Yıl: 2016 Cilt: 31 Sayı: 2 Sayfa Aralığı: 112 - 120 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Glutathione-S-Transferase Variants are not Associated With Increased Carotid Intima-Media Thickness in Turkish Familial Mediterranean Fever Patients

Öz:

Objectives: This study aims to evaluate the carotid intima-media thickness (CIMT) in patients diagnosed with familial Mediterranean fever (FMF) and investigate whether there is a relationship between glutathione-S-transferase (GST) gene polymorphisms and CIMT.Patients and methods: Sixty FMF patients (17 males, 43 females; mean age: 31.43±11.36 years; range 18 to 45 years) and 60 healthy controls (22 males, 38 females; mean age: 29.8±5.82 years; range 18 to 40 years) were enrolled in this study. Polymerase chain reaction-restriction fragment length polymorphism methods were carried out to assess GST polymorphisms. CIMT was measured by carotid ultrasonography. Biochemical parameters were also evaluated using biochemical methods.Results: Right and left CIMT of FMF patients were statistically significantly higher than that of control group (CIMT right p=0.001 and CIMT left: p=0.033). There was no significant association in terms of GST polymorphisms between FMF and control groups. No significant association was observed between GST polymorphisms and CIMT. Low density lipoprotein, erythrocyte sedimentation rate, and fibrinogen levels were significantly higher in the patient group (p<0.05). The difference between groups was not significant in terms of other biochemical parameters (p>0.05).Conclusion: Although no significant association was observed between GST polymorphisms and CIMT in FMF patients and controls, CIMT was statistically significantly higher in FMF patients compared to controls

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Konular: Romatoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	GÜRBÜZ Ö, BAĞCI B, Hüzmeli c, Bağcı G, CANDAN F (2016). Glutathione-S-Transferase Variants are not Associated With Increased Carotid Intima-Media Thickness in Turkish Familial Mediterranean Fever Patients. , 112 - 120.
Chicago	GÜRBÜZ Özlem,BAĞCI Binnur,Hüzmeli can,Bağcı Gökhan,CANDAN Ferhan Glutathione-S-Transferase Variants are not Associated With Increased Carotid Intima-Media Thickness in Turkish Familial Mediterranean Fever Patients. (2016): 112 - 120.
MLA	GÜRBÜZ Özlem,BAĞCI Binnur,Hüzmeli can,Bağcı Gökhan,CANDAN Ferhan Glutathione-S-Transferase Variants are not Associated With Increased Carotid Intima-Media Thickness in Turkish Familial Mediterranean Fever Patients. , 2016, ss.112 - 120.
AMA	GÜRBÜZ Ö,BAĞCI B,Hüzmeli c,Bağcı G,CANDAN F Glutathione-S-Transferase Variants are not Associated With Increased Carotid Intima-Media Thickness in Turkish Familial Mediterranean Fever Patients. . 2016; 112 - 120.
Vancouver	GÜRBÜZ Ö,BAĞCI B,Hüzmeli c,Bağcı G,CANDAN F Glutathione-S-Transferase Variants are not Associated With Increased Carotid Intima-Media Thickness in Turkish Familial Mediterranean Fever Patients. . 2016; 112 - 120.
IEEE	GÜRBÜZ Ö,BAĞCI B,Hüzmeli c,Bağcı G,CANDAN F "Glutathione-S-Transferase Variants are not Associated With Increased Carotid Intima-Media Thickness in Turkish Familial Mediterranean Fever Patients." , ss.112 - 120, 2016.
ISNAD	GÜRBÜZ, Özlem vd. "Glutathione-S-Transferase Variants are not Associated With Increased Carotid Intima-Media Thickness in Turkish Familial Mediterranean Fever Patients". (2016), 112-120.

APA	GÜRBÜZ Ö, BAĞCI B, Hüzmeli c, Bağcı G, CANDAN F (2016). Glutathione-S-Transferase Variants are not Associated With Increased Carotid Intima-Media Thickness in Turkish Familial Mediterranean Fever Patients. Archives of Rheumatology, 31(2), 112 - 120.
Chicago	GÜRBÜZ Özlem,BAĞCI Binnur,Hüzmeli can,Bağcı Gökhan,CANDAN Ferhan Glutathione-S-Transferase Variants are not Associated With Increased Carotid Intima-Media Thickness in Turkish Familial Mediterranean Fever Patients. Archives of Rheumatology 31, no.2 (2016): 112 - 120.
MLA	GÜRBÜZ Özlem,BAĞCI Binnur,Hüzmeli can,Bağcı Gökhan,CANDAN Ferhan Glutathione-S-Transferase Variants are not Associated With Increased Carotid Intima-Media Thickness in Turkish Familial Mediterranean Fever Patients. Archives of Rheumatology, vol.31, no.2, 2016, ss.112 - 120.
AMA	GÜRBÜZ Ö,BAĞCI B,Hüzmeli c,Bağcı G,CANDAN F Glutathione-S-Transferase Variants are not Associated With Increased Carotid Intima-Media Thickness in Turkish Familial Mediterranean Fever Patients. Archives of Rheumatology. 2016; 31(2): 112 - 120.
Vancouver	GÜRBÜZ Ö,BAĞCI B,Hüzmeli c,Bağcı G,CANDAN F Glutathione-S-Transferase Variants are not Associated With Increased Carotid Intima-Media Thickness in Turkish Familial Mediterranean Fever Patients. Archives of Rheumatology. 2016; 31(2): 112 - 120.
IEEE	GÜRBÜZ Ö,BAĞCI B,Hüzmeli c,Bağcı G,CANDAN F "Glutathione-S-Transferase Variants are not Associated With Increased Carotid Intima-Media Thickness in Turkish Familial Mediterranean Fever Patients." Archives of Rheumatology, 31, ss.112 - 120, 2016.
ISNAD	GÜRBÜZ, Özlem vd. "Glutathione-S-Transferase Variants are not Associated With Increased Carotid Intima-Media Thickness in Turkish Familial Mediterranean Fever Patients". Archives of Rheumatology 31/2 (2016), 112-120.