Tp-e/QT and Tp-e/QTc Ratio in Hemodialysis and Peritoneal Dialysis Patients

GÜÇLÜ, AYDIN; İÇLİ, Atilla; ALPAY, Mehmet Fatih; SIPAHIOGLU, MURAT HAYRI; NARMAN, Serkan

Tp-e/QT and Tp-e/QTc Ratio in Hemodialysis and Peritoneal Dialysis Patients

Aydın GÜÇLÜ, (Ahi Evran Üniversitesi, Kırşehir, Türkiye)

Murat Hayri SİPAHİOĞLU, (Erciyes Üniversitesi, Tıp Fakültesi, Nefroloji Anabilim Dalı, Kayseri, Türkiye)

Atilla İÇLİ, (Ahi Evran Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Kırşehir, Türkiye)

Mehmet Fatih ALPAY, (Kırşehir Ahi Evran Üniversitesi, Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Kırşehir, Türkiye)

Serkan NARMAN (Aksaray Üniversitesi, Uygulamalı Matematik Bölümü , Aksaray, Türkiye)

Türk Nefroloji Diyaliz ve Transplantasyon Dergisi

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Yıl: 2016 Cilt: 25 Sayı: 3 Sayfa Aralığı: 273 - 278 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Tp-e/QT and Tp-e/QTc Ratio in Hemodialysis and Peritoneal Dialysis Patients

Öz:

Ani kardiyak ölüm ve aritmi riski son dönem böbrek yetmezliği hastalarında yüksektir. Tp-e/QT, ve Tp-e/QTc' nin ventriküler aritmogenezisi ve ani kardiyak ölümü göstermede QTc' den daha değerli olduğu gösterilmiştir. Çalışmada amacımız hemodiyaliz ve periton diyalizi hastalarında Tp-e intervali, Tp-e/QT ve Tp-e/QTc oranını kullanarak ventriküler repolarizasyonu değerlendirmektir.GEREÇ ve yÖNTEMLER: 35 sağlıklı kontrol, 92 hemodiyaliz hastası, ve 104 periton diyalizi hastası çalışmaya dahil edildi. Bütün hastaların elektrokardiyografileri çekildi. Tp-e interval, Tp-e/QT ve Tp-e/QTc oranı elektrokardiyografiden elde edilen verilerle hesaplandı ve gruplar arasında karşılaştırıldı. BULGULAR: QT hemodiyaliz hastalarında periton diyalizi hastalarına (p<0,001) ve sağlıklı kontrollere (p<0,001) göre yüksek saptandı. Ancak QT periton diyalizi hastalarında sağlıklı kontrollere göre anlamlı fark saptanmadı. QTc, Tp-e, Tp-e/QT, ve Tp-e/QTc hemodiyaliz ve periton diyalizi hastalarında sağlıklı kontrollere göre anlamlı yüksek tespit edildi. Bununla birlikte periton diyalizi ve kontrol grupları arasında QTc değerleri arasında farklılık tespit edilmedi (p:0,081). Diyabetik olmayan bütün son dönem böbrek yetmezliği hastaları sağlıklı kontrollerle karşılaştırıldığında QTc, Tp-e, Tp-e/QT, ve Tp-e/QTc sağlıklı kontrollere göre anlamlı yüksek tespit edildi. Tp-e/QT (p<0,001 r:0,314) ve Tp-e/QTc (p:0,018 r:0,187) arasında ortalama diyaliz süresi (ay) ile pozitifkorelasyon saptandı.SONUÇ: Çalışma Tp-e/QT, ve Tp-e/QTc' nin hemodiyaliz ve periton diyalizi hastalarında sağlıklı kontrollere göre yüksek olduğunu gösteren ilk araştırmadır

Anahtar Kelime:

Konular: Üroloji ve Nefroloji Pediatri

Hemodiyaliz ve Periton Diyalizi HastalarındaTp-e/QT, ve Tp-e/QTc Oranı

Öz:

Sudden cardiac death and risk of arrhythmia are higher in patients with ESRD. Tp-e/QT, and Tp-e/QTc are novel and more reliable indexes of ventricular arrhythmogenesis and sudden cardiac death than QTc. The aim of this study was to assess ventricular repolarization in patients with hemodialysis and peritoneal dialysis by using the Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio. MATERIAL and METHODS: A total of 35 healthy controls, 92 hemodialysis patients, and 104 peritoneal dialysis patients were enrolled in the study. The Tp-e interval, Tp-e/QT, and Tp-e/QTc ratio were calculated from the ECGs of the individuals and compared among groups. RESULTS: QT value was significantly higher in hemodialysis group compared with peritoneal dialysis group (p<0.001) and control group (p<0.001). However a difference was not found comparing QT values between peritoneal dialysis and control groups. Tp-e, Tp-e/QTc, Tp-e/QT, and QTc values were significantly higher in hemodialysis and peritoneal dialysis group comparing to control group. However a statistically significant difference was not found while comparing QTc values between peritoneal dialysis and control groups (p:0.081). When all patients of ESRD without DM were compared with the control group, Tp-e, Tp-e/QTc, Tp-e/QT, and QTc values were found significantly higher than the healthy control group. The values of Tp-e/QT (p<0.001 r:0.314) and Tp-e/QTc (p:0.018 r:0,187) in all patients with kidney disease were found to show positive correlation with duration of dialysis (month). CONCLUSION: This is the first known study that shows Tp-e/Q, and Tp-e/QTc are higher in hemodialysis and peritoneal dialysis patients

Anahtar Kelime:

Konular: Üroloji ve Nefroloji Pediatri

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	GÜÇLÜ A, SIPAHIOGLU M, İÇLİ A, ALPAY M, NARMAN S (2016). Tp-e/QT and Tp-e/QTc Ratio in Hemodialysis and Peritoneal Dialysis Patients. , 273 - 278.
Chicago	GÜÇLÜ AYDIN,SIPAHIOGLU MURAT HAYRI,İÇLİ Atilla,ALPAY Mehmet Fatih,NARMAN Serkan Tp-e/QT and Tp-e/QTc Ratio in Hemodialysis and Peritoneal Dialysis Patients. (2016): 273 - 278.
MLA	GÜÇLÜ AYDIN,SIPAHIOGLU MURAT HAYRI,İÇLİ Atilla,ALPAY Mehmet Fatih,NARMAN Serkan Tp-e/QT and Tp-e/QTc Ratio in Hemodialysis and Peritoneal Dialysis Patients. , 2016, ss.273 - 278.
AMA	GÜÇLÜ A,SIPAHIOGLU M,İÇLİ A,ALPAY M,NARMAN S Tp-e/QT and Tp-e/QTc Ratio in Hemodialysis and Peritoneal Dialysis Patients. . 2016; 273 - 278.
Vancouver	GÜÇLÜ A,SIPAHIOGLU M,İÇLİ A,ALPAY M,NARMAN S Tp-e/QT and Tp-e/QTc Ratio in Hemodialysis and Peritoneal Dialysis Patients. . 2016; 273 - 278.
IEEE	GÜÇLÜ A,SIPAHIOGLU M,İÇLİ A,ALPAY M,NARMAN S "Tp-e/QT and Tp-e/QTc Ratio in Hemodialysis and Peritoneal Dialysis Patients." , ss.273 - 278, 2016.
ISNAD	GÜÇLÜ, AYDIN vd. "Tp-e/QT and Tp-e/QTc Ratio in Hemodialysis and Peritoneal Dialysis Patients". (2016), 273-278.

APA	GÜÇLÜ A, SIPAHIOGLU M, İÇLİ A, ALPAY M, NARMAN S (2016). Tp-e/QT and Tp-e/QTc Ratio in Hemodialysis and Peritoneal Dialysis Patients. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, 25(3), 273 - 278.
Chicago	GÜÇLÜ AYDIN,SIPAHIOGLU MURAT HAYRI,İÇLİ Atilla,ALPAY Mehmet Fatih,NARMAN Serkan Tp-e/QT and Tp-e/QTc Ratio in Hemodialysis and Peritoneal Dialysis Patients. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi 25, no.3 (2016): 273 - 278.
MLA	GÜÇLÜ AYDIN,SIPAHIOGLU MURAT HAYRI,İÇLİ Atilla,ALPAY Mehmet Fatih,NARMAN Serkan Tp-e/QT and Tp-e/QTc Ratio in Hemodialysis and Peritoneal Dialysis Patients. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, vol.25, no.3, 2016, ss.273 - 278.
AMA	GÜÇLÜ A,SIPAHIOGLU M,İÇLİ A,ALPAY M,NARMAN S Tp-e/QT and Tp-e/QTc Ratio in Hemodialysis and Peritoneal Dialysis Patients. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi. 2016; 25(3): 273 - 278.
Vancouver	GÜÇLÜ A,SIPAHIOGLU M,İÇLİ A,ALPAY M,NARMAN S Tp-e/QT and Tp-e/QTc Ratio in Hemodialysis and Peritoneal Dialysis Patients. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi. 2016; 25(3): 273 - 278.
IEEE	GÜÇLÜ A,SIPAHIOGLU M,İÇLİ A,ALPAY M,NARMAN S "Tp-e/QT and Tp-e/QTc Ratio in Hemodialysis and Peritoneal Dialysis Patients." Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, 25, ss.273 - 278, 2016.
ISNAD	GÜÇLÜ, AYDIN vd. "Tp-e/QT and Tp-e/QTc Ratio in Hemodialysis and Peritoneal Dialysis Patients". Türk Nefroloji Diyaliz ve Transplantasyon Dergisi 25/3 (2016), 273-278.