Physical examination of a 3080 g male infant born at 39, gestational week revealed extensive absence of cutaneous epithelial layer of lower extremities including feet and bullous lesions in both hands, more pronounced on the left. During follow-up period he developed new bullous lesions with minor traumas Moreover, he had nail dystrophies on both hands. He was diagnosed as Bart syndrome with the findings including aplasia cutis, epidermolysis bullosa and dystrophic nails. Systhemic and local antibacterial and antifungal treatments were started and he was discharged at fifth postnatal week when adequate superficial epithelization was achieved, he was discharged after his family received training on maintenance of his care. Bart syndrome is a rare genetic disorder characterized by conjenital skin defects (aplasia cutis), epidermolysis bullosa and dystrophic nails. Several hypothesis have been suggested to explain the co-existance of aplasia cutis and epidermolysis bullosa. Most commonly accepted hypothesis is that, cutis aplasia emerges due to the friction of affected lower extremities during intrauterne period