High sensitive CRP and sICAM-1 can predict Major Adverse Cardiovascular Events: MELEN Study: A Large Turkish Population Based Study

DEMİRİN, Hilmi; Bahadır, anzel; Besli, Feyzullah; Kayapınar, Osman; özhan, hakan; UÇGUN, Taner; BALTACI, Davut; TÜRKER, Yasin; BAŞAR, Cengiz; TÜRKER, Yasemin; ERÖZ, Recep; KUTLUCAN, Ali

High sensitive CRP and sICAM-1 can predict Major Adverse Cardiovascular Events: MELEN Study: A Large Turkish Population Based Study

Yasin TÜRKER, (Süleyman Demirel Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Isparta, Türkiye)

Osman KAYAPINAR, (Düzce Üniversitesi, Düzce Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Düzce, Türkiye)

Hilmi DEMİRİN, (Düzce Üniversitesi, Tıp Fakültesi, Klinik Biyokimya Anabilim Dalı, Düzce, Türkiye)

Recep ERÖZ, (Düzce Üniversitesi, Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı, Düzce, Türkiye)

Ali KUTLUCAN, (Selçuk Üniversitesi, Meram Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Konya, Türkiye)

Yasemin TÜRKER, (Düzce Devlet Hastanesi Aile Hekimliği Polikliniği, Aile Hekimliği, Düzce, Türkiye)

Cengiz BAŞAR, (Düzce Atatürk Devlet Hastanesi, Kardiyoloji Kliniği, Düzce, Türkiye)

FEYZULLAH BEŞLİ, (Düzce Atatürk Devlet Hastanesi, Kardiyoloji Kliniği, Düzce, Türkiye)

Taner UÇGUN, (Düzce Üniversitesi, Tıp Fakültesi, Klinik Biyokimya Anabilim Dalı, Düzce, Türkiye)

Hakan ÖZHAN, (Düzce Üniversitesi, Düzce Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Düzce, Türkiye)

Anzel BAHADIR, (Düzce Üniversitesi, Tıp Fakültesi, Biyofizik Anabilim Dalı, Düzce, Türkiye)

Davut BALTACI, (Düzce Üniversitesi, Tıp Fakültesi, Aile Hekimliği Anabilim Dalı, Düzce, Türkiye)

Diğer Yazarlar

KONURALP TIP DERGİSİ

4 3

Yıl: 2016 Cilt: 8 Sayı: 1 Sayfa Aralığı: 14 - 22 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

High sensitive CRP and sICAM-1 can predict Major Adverse Cardiovascular Events: MELEN Study: A Large Turkish Population Based Study

Öz:

Amaç: Major istenmeyen kardiyovasküler olayların (MACE) belirteçlerini prospektif popülasyon bazlı bir çalışmada değerlendirmeyi amaçladık. Metod: Bu çalışmaya, SCORE risk değerlendirmesine göre yüksek ve çok yüksek kardiyovasküler riske sahip 40 yaş üstü 153 katılımcı ile düşük kardiyovasküler riske sahip 40 yaş üstü 50 katılımcı dahil edildi. Tüm katılımcılara karotis intima media kalınlığı (CIMT) ölçümü için bir doppler ultrasonografi, ekokardiyografi uygulandı., EKG kaydı alındı ve çeşitli biyokimyasal analizler yapıldı. Yüksek duyarlı CRP (hsCRP) kemilüminesans immünometrik yöntem ile ölçüldü, serum amyloid-A (SAA) protein, çözünebilir hücrelerarası adezyon molekülü-1 (sICAM), apolipoprotein-B (ApoB) ELISA method ile ölçüldü. eNOS tek nükleotid polimorfizmi polimeraz zincir reaksiyonu ve restriksiyon uzunluk parça polimorfizmi yöntemlerinin uygulanması ile saptandı. Çalışmaya başlangıcından itibaren 36 ay takip yapıldı. MACE kardiyovasküler mortalite ya da miyokard infarktüsü veya inme olarak tanımlandı. Bulgular: MACE sıklığı düşük risk grubuna göre yüksek ve çok yüksek risk grubunda daha yüksekti. eNOS gen polimorfizmleri açısından risk grupları ve kontrol grubu arasında anlamlı fark yoktu, eNOS gen polimorfizmleri ve MACE arasında anlamlı bir ilişki saptanmadı. Yaş, ejeksiyon fraksiyonu (EF), CIMT, hsCRP, ApoB, sICAM-1 ve SAA protein düzeyleri ile MACE arasında tek değişkenli lojistik regresyon analizinde anlamlı ilişki bulunmuştur. Çok değişkenli analizde yaş (OR: 1.08, CI: 1.02-1.15, p=0.013), EF (OR: 0.94, CI: 0,89-0,99, p=0.016), hsCRP (OR: 1.36, CI: 1,12-1,67, p=0.003) ve sICAM-1 (OR: 81.0, CI: 1,04-6320, p=0.048) düzeyleri MACE için bağımsız belirteç olduğu gösterildi. Sonuç: Yüksek yaş, hsCRP, sICAM-1 seviyeleri ve düşük EF MACE için bağımsız belirteçlerdir

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Yüksek Duyarlı CRP ve sICAM-1 Major İstenmeyen Kardiyovasküler Olayları Tahmin Ettirebilir: MELEN Çalışması: Popülasyon BazlıGenişEpidemiyolojik Çalışma

Öz:

Objective: We aimed to evaluate the predictors of major adverse cardiovascular events (MACE) in a prospective population based study. Methods: This study included 153 participants aged>40 years with high and very high cardiovascular risk, and 50 participants aged>40 years with low cardiovascular risk according to the SCORE risk assessment. All the participants underwent a doppler ultrasound examination of carotid intima media thickness (CIMT), echocardiographic examination, ECG recording and various biochemical analyses. High-sensitivity Creactive protein (hsCRP) was measured with chemiluminescent immunometric assay, serum amyloid-A (SAA) protein, soluble intercellular adhesion molecule-1 (sICAM), apolipoprotein-B (ApoB) were measured with ELISA method. eNOS single-nucleotide polymorphism was detected using polymerase chain reaction and restriction fragment length polymorphism methods. The follow-up was done 36 months after the baseline admission. MACE was defined as cardiovascular mortality or myocardial infarction or stroke. Results: Frequency of MACE was higher in high and very high risk group according to low risk group. There were no significant differences in eNOS gene polymorphisms between the risk groups and control subjects, and no significant association between eNOS gene polymorphisms and MACE was detected. Age, ejection fraction (EF), CIMT, hsCRP, ApoB, sICAM-1, and SAA protein levels were all significantly associated with MACE in univariate logistic regression analyses. Multivariate analyses revealed that age (OR:1.08, CI:1.02-1.15, p=0.013), EF (OR:0.94, CI:0.89-0.99, p=0.016), hsCRP (OR:1.36, CI:1.12-1.67, p=0.003) and sICAM-1 (OR:81.0, CI: 1.04-6320, p=0.048) levels were the only independent predictors of MACE. Conclusion: Higher age, hsCRP and sICAM-1 levels and lower EF were independent predictors of MACE

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	TÜRKER Y, Kayapınar O, DEMİRİN H, ERÖZ R, KUTLUCAN A, TÜRKER Y, BAŞAR C, Besli F, UÇGUN T, özhan h, Bahadır a, BALTACI D (2016). High sensitive CRP and sICAM-1 can predict Major Adverse Cardiovascular Events: MELEN Study: A Large Turkish Population Based Study. , 14 - 22.
Chicago	TÜRKER Yasin,Kayapınar Osman,DEMİRİN Hilmi,ERÖZ Recep,KUTLUCAN Ali,TÜRKER Yasemin,BAŞAR Cengiz,Besli Feyzullah,UÇGUN Taner,özhan hakan,Bahadır anzel,BALTACI Davut High sensitive CRP and sICAM-1 can predict Major Adverse Cardiovascular Events: MELEN Study: A Large Turkish Population Based Study. (2016): 14 - 22.
MLA	TÜRKER Yasin,Kayapınar Osman,DEMİRİN Hilmi,ERÖZ Recep,KUTLUCAN Ali,TÜRKER Yasemin,BAŞAR Cengiz,Besli Feyzullah,UÇGUN Taner,özhan hakan,Bahadır anzel,BALTACI Davut High sensitive CRP and sICAM-1 can predict Major Adverse Cardiovascular Events: MELEN Study: A Large Turkish Population Based Study. , 2016, ss.14 - 22.
AMA	TÜRKER Y,Kayapınar O,DEMİRİN H,ERÖZ R,KUTLUCAN A,TÜRKER Y,BAŞAR C,Besli F,UÇGUN T,özhan h,Bahadır a,BALTACI D High sensitive CRP and sICAM-1 can predict Major Adverse Cardiovascular Events: MELEN Study: A Large Turkish Population Based Study. . 2016; 14 - 22.
Vancouver	TÜRKER Y,Kayapınar O,DEMİRİN H,ERÖZ R,KUTLUCAN A,TÜRKER Y,BAŞAR C,Besli F,UÇGUN T,özhan h,Bahadır a,BALTACI D High sensitive CRP and sICAM-1 can predict Major Adverse Cardiovascular Events: MELEN Study: A Large Turkish Population Based Study. . 2016; 14 - 22.
IEEE	TÜRKER Y,Kayapınar O,DEMİRİN H,ERÖZ R,KUTLUCAN A,TÜRKER Y,BAŞAR C,Besli F,UÇGUN T,özhan h,Bahadır a,BALTACI D "High sensitive CRP and sICAM-1 can predict Major Adverse Cardiovascular Events: MELEN Study: A Large Turkish Population Based Study." , ss.14 - 22, 2016.
ISNAD	TÜRKER, Yasin vd. "High sensitive CRP and sICAM-1 can predict Major Adverse Cardiovascular Events: MELEN Study: A Large Turkish Population Based Study". (2016), 14-22.

APA	TÜRKER Y, Kayapınar O, DEMİRİN H, ERÖZ R, KUTLUCAN A, TÜRKER Y, BAŞAR C, Besli F, UÇGUN T, özhan h, Bahadır a, BALTACI D (2016). High sensitive CRP and sICAM-1 can predict Major Adverse Cardiovascular Events: MELEN Study: A Large Turkish Population Based Study. KONURALP TIP DERGİSİ, 8(1), 14 - 22.
Chicago	TÜRKER Yasin,Kayapınar Osman,DEMİRİN Hilmi,ERÖZ Recep,KUTLUCAN Ali,TÜRKER Yasemin,BAŞAR Cengiz,Besli Feyzullah,UÇGUN Taner,özhan hakan,Bahadır anzel,BALTACI Davut High sensitive CRP and sICAM-1 can predict Major Adverse Cardiovascular Events: MELEN Study: A Large Turkish Population Based Study. KONURALP TIP DERGİSİ 8, no.1 (2016): 14 - 22.
MLA	TÜRKER Yasin,Kayapınar Osman,DEMİRİN Hilmi,ERÖZ Recep,KUTLUCAN Ali,TÜRKER Yasemin,BAŞAR Cengiz,Besli Feyzullah,UÇGUN Taner,özhan hakan,Bahadır anzel,BALTACI Davut High sensitive CRP and sICAM-1 can predict Major Adverse Cardiovascular Events: MELEN Study: A Large Turkish Population Based Study. KONURALP TIP DERGİSİ, vol.8, no.1, 2016, ss.14 - 22.
AMA	TÜRKER Y,Kayapınar O,DEMİRİN H,ERÖZ R,KUTLUCAN A,TÜRKER Y,BAŞAR C,Besli F,UÇGUN T,özhan h,Bahadır a,BALTACI D High sensitive CRP and sICAM-1 can predict Major Adverse Cardiovascular Events: MELEN Study: A Large Turkish Population Based Study. KONURALP TIP DERGİSİ. 2016; 8(1): 14 - 22.
Vancouver	TÜRKER Y,Kayapınar O,DEMİRİN H,ERÖZ R,KUTLUCAN A,TÜRKER Y,BAŞAR C,Besli F,UÇGUN T,özhan h,Bahadır a,BALTACI D High sensitive CRP and sICAM-1 can predict Major Adverse Cardiovascular Events: MELEN Study: A Large Turkish Population Based Study. KONURALP TIP DERGİSİ. 2016; 8(1): 14 - 22.
IEEE	TÜRKER Y,Kayapınar O,DEMİRİN H,ERÖZ R,KUTLUCAN A,TÜRKER Y,BAŞAR C,Besli F,UÇGUN T,özhan h,Bahadır a,BALTACI D "High sensitive CRP and sICAM-1 can predict Major Adverse Cardiovascular Events: MELEN Study: A Large Turkish Population Based Study." KONURALP TIP DERGİSİ, 8, ss.14 - 22, 2016.
ISNAD	TÜRKER, Yasin vd. "High sensitive CRP and sICAM-1 can predict Major Adverse Cardiovascular Events: MELEN Study: A Large Turkish Population Based Study". KONURALP TIP DERGİSİ 8/1 (2016), 14-22.