Relationship Between Leptin and Neopterin Levels and Disease Activation Parameters in Patients With Rheumatoid Arthritis

KAYA, Arzu; GÜLKESEN, Arif; AKGÖL, Gürkan; KAL, Gül Ayden; TUNCER, Türkan; TELO, Selda; POYRAZ, AHMET KURSAD

Relationship Between Leptin and Neopterin Levels and Disease Activation Parameters in Patients With Rheumatoid Arthritis

Arif GÜLKESEN, (Fırat Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Elazığ, Türkiye)

Gürkan AKGÖL, (Fırat Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Elazığ, Türkiye)

Türkan TUNCER, (Siirt Devlet Hastanesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Siirt, Türkiye)

Gül Ayden KAL, (Sağlık Bakanlığı, Elazığ Eğitim ve Araştırma Hastanesi, Fiziksel Tıp ve Rehabilitasyon Bölümü, Elazığ, Türkiye)

Selda TELO, (Fırat Üniversitesi, Tıp Fakültesi, Biyokimya ve Klinik Biyokimya Anabilim Dalı, Elazığ, Türkiye)

Ahmet KÜRŞAD POYRAZ, (Fırat Üniversitesi, Tıp Fakültesi, Biyokimya ve Klinik Biyokimya Anabilim Dalı, Elazığ, Türkiye)

Arzu KAYA (Fırat Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Elazığ, Türkiye)

Archives of Rheumatology

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Yıl: 2016 Cilt: 31 Sayı: 4 Sayfa Aralığı: 333 - 339 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Relationship Between Leptin and Neopterin Levels and Disease Activation Parameters in Patients With Rheumatoid Arthritis

Öz:

Objectives: This study aims to determine serum leptin and neopterin levels in patients with rheumatoid arthritis (RA) and investigate the relationship between clinical and laboratory parameters of disease activity and radiographic progression.Patients and methods: The study included 33 RA patients (9 males, 24 females; mean age 52.5±12.3 years; range 29 to 75 years) and age- and sex-matched 24 healthy controls (11 males, 13 females, mean age 42.5±14.8; range 18 to 75). RA patients were divided into three groups based on Disease Activity Scores in 28 joints (DAS28) as low disease activity, moderate disease activity, and high disease activity groups. Of the patients, 13 (39.4%) had low disease activity (DAS28=2.6-3.2), 12 (36.4%) had moderate disease activity (DAS28=3.2-5.1), and eight (24.2%) had high disease activity (DAS28>=5.1).Results: Mean serum leptin and neopterin levels in the RA group were 23.98±18.88 ng/mL and 1.88±1.84 nmol/L, respectively. Mean serum leptin and neopterin levels in the control group were 19.40±13:42 ng/mL and 1.13±0.55 nmol/L, respectively. There was no statistically significant difference in the levels of serum leptin (p=0.674) and neopterin (p=0.078) between RA patients and control group. Serum leptin (p=0.574) and neopterin (p=0.921) levels in RA patients and control group showed no correlation with body mass index levels. Besides, there was no correlation between age and plasma leptin and neopterin levels and rheumatoid factor positivity, anti-cyclic citrullinated peptide antibodies, disease duration, erythrocyte sedimentation rate, and C-reactive protein levels in RA group. In RA patients, there was no correlation between serum leptin and neopterin levels and clinical and laboratory parameters indicating the disease activity. In RA patients, there was also no correlation between radiographic joint damage and serum leptin and neopterin levels. A positive correlation was shown in RA patients between disease duration and modified Larsen score (p=0.01).Conclusion: In our study, no correlation was detected between serum leptin and neopterin levels and disease activity parameters in RA patients. Therefore, leptin and neopterin levels may not be considered as beneficial inflammation parameters to be used in the diagnosis of RA and disease activation tracking.

Anahtar Kelime:

Konular: Romatoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	GÜLKESEN A, AKGÖL G, TUNCER T, KAL G, TELO S, POYRAZ A, KAYA A (2016). Relationship Between Leptin and Neopterin Levels and Disease Activation Parameters in Patients With Rheumatoid Arthritis. , 333 - 339.
Chicago	GÜLKESEN Arif,AKGÖL Gürkan,TUNCER Türkan,KAL Gül Ayden,TELO Selda,POYRAZ AHMET KURSAD,KAYA Arzu Relationship Between Leptin and Neopterin Levels and Disease Activation Parameters in Patients With Rheumatoid Arthritis. (2016): 333 - 339.
MLA	GÜLKESEN Arif,AKGÖL Gürkan,TUNCER Türkan,KAL Gül Ayden,TELO Selda,POYRAZ AHMET KURSAD,KAYA Arzu Relationship Between Leptin and Neopterin Levels and Disease Activation Parameters in Patients With Rheumatoid Arthritis. , 2016, ss.333 - 339.
AMA	GÜLKESEN A,AKGÖL G,TUNCER T,KAL G,TELO S,POYRAZ A,KAYA A Relationship Between Leptin and Neopterin Levels and Disease Activation Parameters in Patients With Rheumatoid Arthritis. . 2016; 333 - 339.
Vancouver	GÜLKESEN A,AKGÖL G,TUNCER T,KAL G,TELO S,POYRAZ A,KAYA A Relationship Between Leptin and Neopterin Levels and Disease Activation Parameters in Patients With Rheumatoid Arthritis. . 2016; 333 - 339.
IEEE	GÜLKESEN A,AKGÖL G,TUNCER T,KAL G,TELO S,POYRAZ A,KAYA A "Relationship Between Leptin and Neopterin Levels and Disease Activation Parameters in Patients With Rheumatoid Arthritis." , ss.333 - 339, 2016.
ISNAD	GÜLKESEN, Arif vd. "Relationship Between Leptin and Neopterin Levels and Disease Activation Parameters in Patients With Rheumatoid Arthritis". (2016), 333-339.

APA	GÜLKESEN A, AKGÖL G, TUNCER T, KAL G, TELO S, POYRAZ A, KAYA A (2016). Relationship Between Leptin and Neopterin Levels and Disease Activation Parameters in Patients With Rheumatoid Arthritis. Archives of Rheumatology, 31(4), 333 - 339.
Chicago	GÜLKESEN Arif,AKGÖL Gürkan,TUNCER Türkan,KAL Gül Ayden,TELO Selda,POYRAZ AHMET KURSAD,KAYA Arzu Relationship Between Leptin and Neopterin Levels and Disease Activation Parameters in Patients With Rheumatoid Arthritis. Archives of Rheumatology 31, no.4 (2016): 333 - 339.
MLA	GÜLKESEN Arif,AKGÖL Gürkan,TUNCER Türkan,KAL Gül Ayden,TELO Selda,POYRAZ AHMET KURSAD,KAYA Arzu Relationship Between Leptin and Neopterin Levels and Disease Activation Parameters in Patients With Rheumatoid Arthritis. Archives of Rheumatology, vol.31, no.4, 2016, ss.333 - 339.
AMA	GÜLKESEN A,AKGÖL G,TUNCER T,KAL G,TELO S,POYRAZ A,KAYA A Relationship Between Leptin and Neopterin Levels and Disease Activation Parameters in Patients With Rheumatoid Arthritis. Archives of Rheumatology. 2016; 31(4): 333 - 339.
Vancouver	GÜLKESEN A,AKGÖL G,TUNCER T,KAL G,TELO S,POYRAZ A,KAYA A Relationship Between Leptin and Neopterin Levels and Disease Activation Parameters in Patients With Rheumatoid Arthritis. Archives of Rheumatology. 2016; 31(4): 333 - 339.
IEEE	GÜLKESEN A,AKGÖL G,TUNCER T,KAL G,TELO S,POYRAZ A,KAYA A "Relationship Between Leptin and Neopterin Levels and Disease Activation Parameters in Patients With Rheumatoid Arthritis." Archives of Rheumatology, 31, ss.333 - 339, 2016.
ISNAD	GÜLKESEN, Arif vd. "Relationship Between Leptin and Neopterin Levels and Disease Activation Parameters in Patients With Rheumatoid Arthritis". Archives of Rheumatology 31/4 (2016), 333-339.