A cardiac involvement in Wilson's disease includes left ventricular hypertrophy, severe atherosclerosis, sudden cardiac death, and various arrhythmias. In this report, a case with Wilson's disease and Wolff-Parkinson-White syndrome is discussed with the relevant literature. A 22-year-old male patient presented to the hospital complaining of chest pain. The patient had the diagnosis of Wilson's disease. He had short periods of palpitations for 2 years but no tachycardic period was detected in his 24-hour electrocardiogram holter monitoring. An electrocardiogram showed a shortened PR interval and prominent delta waves supporting the diagnosis of Wolff-Parkinson-White syndrome. The patient was hospitalized and subsequently transferred to electrophysiologic mapping. The accessory pathway was eliminated with radiofrequency ablation catheter. Patients with Wilson's disease who have palpitations should be evaluated for possible arrhythmias and electrocardiography should be performed. In this report, a case with Wilson's disease and Wolff-Parkinson-White syndrome is discussed with the relevant literatures.