Yıl: 2014 Cilt: 44 Sayı: 3 Sayfa Aralığı: 524 - 529 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Pulsatile ocular blood flow changes after panretinal photocoagulation treatment in patients with proliferative diabetic retinopathy

Öz:
Background/aim: To prospectively assess the effects of panretinal photocoagulation (PRP) treatment on pulsatile ocular blood flow (POBF) in patients with proliferative diabetic retinopathy (PDRP). Materials and methods: The study included 40 eyes with PDRP in 27 patients. The PRP treatments were completed in 3 sessions with 3-week intervals. The intraocular pressure (IOP), pulse amplitude (PA), pulse volume (PV), and POBF changes that arose during the sessions were recorded using a blood flow analyzer. Results: The average age of the patients was 57.37 ± 11.14 years. The pre-PRP basal IOP, PA, PV, and POBF values were 20.44 ± 4.13 mmHg, 4.23 ± 1.73 mmHg, 6.89 ± 2.28 µL, and 21.86 ± 5.83 µL/s, respectively. One month after the completion of the PRP sessions, the values were 18.49 ± 4.44 mmHg, 2.78 ± 1.13 mmHg, 5.27 ± 2.08 µL, and 15.89 ± 5.05 µL/s, respectively, and the differences were significant (P = 0.001, P < 0.0001, P < 0.0001, and P < 0.0001, respectively). Conclusion: PRP treatment reduces the choroidal blood flow and consequently causes significant decreases in IOP, PA, PV, and POBF.
Anahtar Kelime:

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Fisher EB, Thorpe CT, Devellis BM, Devellis RF. Healthy coping, negative emotions, and diabetes management: a systematic review and appraisal. Diabetes Educ 2007; 33: 1080–1103.
  • 2. Turk A, Nuhoglu I, Mentese A, Karahan SC, Erdol H, Erem C. The relationship between diabetic retinopathy and serum levels of ischaemia-modified albumin (IMA) and malondialdehyde (MDA). Retina 2011; 31: 602–608.
  • 3. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004; 27: 1047–1053.
  • 4. Natali A, Ferrannini E. Hypertension, insulin resistance, and the metabolic syndrome. Endocrinol Metab Clin North Am 2004; 33: 417–429.
  • 5. American Diabetes Association. Economic costs of diabetes in the U.S. in 2007. Diabetes Care 2008; 31: 596–615.
  • 6. Erdol H, Turk A, Akyol N, Imamoglu HI. The results of intravitreal bevacizumab injections for persistent neovascularizations in proliferative diabetic retinopathy following photocoagulation therapy. Retina 2010; 30: 570–577.
  • 7. Savage HI, Hendrix JW, Peterson DC, Young H, Wilkinson CP. Differences in pulsatile ocular blood flow among three classifications of diabetic retinopathy. Invest Ophthalmol Vis Sci 2004; 45: 4504–4509.
  • 8. Kim SK, Cho BJ, Hong S, Kang SY, Kim JS, Kim CY, Seong GJ. Pulsatile ocular blood flow in healthy Koreans. Korean J Ophthalmol 2008; 22: 6–9.
  • 9. Takahashi A, Nagaoka T, Sato E, Yoshida A. Effect of panretinal photocoagulation on choroidal circulation in the foveal region in patients with severe diabetic retinopathy. Br J Ophthalmol 2008; 92: 1369–1373.
  • 10. Perrott RL, Drasdo N, Owens DR, North RV. Can pulsatile ocular blood flow distinguish between patients with and without diabetic retinopathy? Clin Exp Optom 2007; 90: 445–450.
  • 11. Krepler K, Polska E, Wedrich A, Schmetterer L. Ocular blood flow parameters after pars plana vitrectomy in patients with diabetic retinopathy. Retina 2003; 23: 192–196.
  • 12. Langham ME, Farrell RA, O’Brien V, Silver DM, Schilder P. Blood flow in the human eye. Acta Ophthalmol Suppl 1989; 191: 9–13.
  • 13. Eisenlohr JE, Langham ME, Maumenee AE. Manometric studies of the pressure-volume relationship in living and enucleated eyes of individual human subjects. Br J Ophthalmol 1962; 46: 536–548.
  • 14. Silver DM, Farrell RA, Langham ME, O’Brien V, Schilder P. Estimation of pulsatile ocular blood flow from intraocular pressure. Acta Ophthalmol Suppl 1989; 191: 25–29.
  • 15. Silver DM, Farrell RA. Validity of pulsatile ocular blood flow measurements. Surv Ophthalmol 1994; 38: S72–S80.
  • 16. Leske MC, Wu SY, Hennis A, Honkanen R, Nemesure B; BESs Study Group. Risk factors for incident open-angle glaucoma: the Barbados Eye Studies. Ophthalmology 2008; 115: 85–93.
  • 17. Janulevičiene I, Ehrlich R, Siesky B, Nedzelskienė I, Harris A. Evaluation of hemodynamic parameters as predictors of glaucoma progression. J Ophthalmol 2011; 2011: 164320.
  • 18. Mori F, Konno S, Hikichi T, Yamaguchi Y, Ishiko S, Yoshida A. Pulsatile ocular blood flow study: decreases in exudative age related macular degeneration. Br J Ophthalmol 2001; 85: 531–533.
  • 19. Hopkins SD. Ocular haemodynamics in cataractous eyes. A pilot study. Acta Ophthalmol Suppl 1989; 191: 43–48.
  • 20. Langham ME, Grebe R, Hopkins S, Marcus S, Sebag M. Choroidal blood flow in diabetic retinopathy. Exp Eye Res 1991; 52: 167–173.
  • 21. Schmitt K, Hessemer V. Effect of panretinal photocoagulation on the ocular pulse curve. Klin Monbl Augenheilkd 1997; 210: 53–57 (article in German with abstract in English).
  • 22. Gunvant P, Baskaran M, Vijaya L, Joseph IS, Watkins RJ, Nallapothula M, Broadway DC, O’Leary DJ. Effect of corneal parameters on measurements using the pulsatile ocular blood flow tonograph and Goldmann applanation tonometer. Br J Ophthalmol 2004; 88: 518–522.
  • 23. Ravalico G, Toffoli G, Pastori G, Crocè M, Calderini S. Agerelated ocular blood flow changes. Invest Ophthalmol Vis Sci 1996; 37: 2645–2650.
  • 24. Saleh TA, Adams M, McDermott B, Claridge KG, Ewings P. Effects of central corneal thickness and corneal curvature on the intraocular pressure measurement by Goldmann applanation tonometer and ocular blood flow pneumatonometer. Clin Experiment Ophthalmol 2006; 34: 516–520.
  • 25. Benavente-Pérez A, Hosking SL, Logan NS, Broadway DC. Ocular blood flow measurements in healthy human myopic eyes. Graefes Arch Clin Exp Ophthalmol 2010; 248: 1587– 1594.
  • 26. Esgin H, Alimgil ML, Erda S. The effect of systemic hypertension on pulsatile ocular blood flow in diabetic patients. Acta Ophthalmol Scand 2001; 79: 160–162.
  • 27. Fontana L, Poinoosawmy D, Bunce CV, O’Brien C, Hitchings RA. Pulsatile ocular blood flow investigation in asymmetric normal tension glaucoma and normal subjects. Br J Ophthalmol 1998; 82: 731–736.
  • 28. Early Treatment Diabetic Retinopathy Study Research Group. Fundus photographic risk factors for progression of diabetic retinopathy. ETDRS report number 12. Ophthalmology 1991; 98: 823–833.
  • 29. Agarwal HC, Gupta V, Sihota R, Singh K. Pulsatile ocular blood flow among normal subjects and patients with high tension glaucoma. Indian J Ophthalmol 2003; 51: 133–138.
  • 30. Geyer O, Neudorfer M, Snir T, Goldstein M, Rock T, Silver DM, Bartov E. Pulsatile ocular blood flow in diabetic retinopathy. Acta Ophthalmol Scand 1999; 77: 522–525.
  • 31. MacKinnon JR, O’Brien C, Swa K, Aspinall P, Butt Z, Cameron D. Pulsatile ocular blood flow in untreated diabetic retinopathy. Acta Ophthalmol Scand 1997; 75: 661–664.
  • 32. Mendivil A, Cuartero V. Ocular blood flow velocities in patients with proliferative diabetic retinopathy after scatter photocoagulation. Two years of follow-up. Retina 1996; 16: 222–227.
  • 33. Hessemer V, Schmidt KG. Influence of panretinal photocoagulation on the ocular pulse curve. Am J Ophthalmol 1997; 123: 748–752.
  • 34. Grunwald JE, Riva CE, Brucker AJ, Sinclair SH, Petrig BL. Effect of panretinal photocoagulation on retinal blood flow in proliferative diabetic retinopathy. Ophthalmology 1986; 93: 590–595.
  • 35. Caldwell RB, Bartoli M, Behzadian MA, El-Remessy AE, Al-Shabrawey M, Platt DH, Liou GI, Caldwell RW. Vascular endothelial growth factor and diabetic retinopathy: role of oxidative stress. Curr Drug Targets 2005; 6: 511–524.
  • 36. Caldwell RB, Bartoli M, Behzadian MA, El-Remessy AE, AlShabrawey M, Platt DH, Caldwell RW. Vascular endothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives. Diabetes Metab Res Rev 2003; 19: 442–455.
  • 37. Perrott RL, North RV, Drasdo N, Ahmed KA, Owens DR. The influence of plasma glucose upon pulsatile ocular blood flow in subjects with type II diabetes mellitus. Diabetologia 2001; 44: 700–705.
  • 38. Caprioli J, Coleman AL; Blood Flow in Glaucoma Discussion. Blood pressure, perfusion pressure, and glaucoma. Am J Ophthalmol 2010; 149: 704–712.
  • 39. Blondeau P, Pavan PR, Phelps CD. Acute pressure elevation following panretinal photocoagulation. Arch Ophthalmol 1981; 99: 1239–1241.
  • 40. Schiødte SN, Scherfig E, Nissen OI. A pressure lowering effect of retinal xenon photocoagulation in normotensive diabetic eyes. Acta Ophthalmol (Copenh) 1980; 58: 369–376.
APA Turk A, ESENÜLKÜ C, Akyol N, KOLA M, Erdöl H, İmamoğlu H (2014). Pulsatile ocular blood flow changes after panretinal photocoagulation treatment in patients with proliferative diabetic retinopathy. , 524 - 529.
Chicago Turk Adem,ESENÜLKÜ Cenap Mahmut,Akyol Nurettin,KOLA Mehmet,Erdöl Hidayet,İmamoğlu Halil İbrahim Pulsatile ocular blood flow changes after panretinal photocoagulation treatment in patients with proliferative diabetic retinopathy. (2014): 524 - 529.
MLA Turk Adem,ESENÜLKÜ Cenap Mahmut,Akyol Nurettin,KOLA Mehmet,Erdöl Hidayet,İmamoğlu Halil İbrahim Pulsatile ocular blood flow changes after panretinal photocoagulation treatment in patients with proliferative diabetic retinopathy. , 2014, ss.524 - 529.
AMA Turk A,ESENÜLKÜ C,Akyol N,KOLA M,Erdöl H,İmamoğlu H Pulsatile ocular blood flow changes after panretinal photocoagulation treatment in patients with proliferative diabetic retinopathy. . 2014; 524 - 529.
Vancouver Turk A,ESENÜLKÜ C,Akyol N,KOLA M,Erdöl H,İmamoğlu H Pulsatile ocular blood flow changes after panretinal photocoagulation treatment in patients with proliferative diabetic retinopathy. . 2014; 524 - 529.
IEEE Turk A,ESENÜLKÜ C,Akyol N,KOLA M,Erdöl H,İmamoğlu H "Pulsatile ocular blood flow changes after panretinal photocoagulation treatment in patients with proliferative diabetic retinopathy." , ss.524 - 529, 2014.
ISNAD Turk, Adem vd. "Pulsatile ocular blood flow changes after panretinal photocoagulation treatment in patients with proliferative diabetic retinopathy". (2014), 524-529.
APA Turk A, ESENÜLKÜ C, Akyol N, KOLA M, Erdöl H, İmamoğlu H (2014). Pulsatile ocular blood flow changes after panretinal photocoagulation treatment in patients with proliferative diabetic retinopathy. Turkish Journal of Medical Sciences, 44(3), 524 - 529.
Chicago Turk Adem,ESENÜLKÜ Cenap Mahmut,Akyol Nurettin,KOLA Mehmet,Erdöl Hidayet,İmamoğlu Halil İbrahim Pulsatile ocular blood flow changes after panretinal photocoagulation treatment in patients with proliferative diabetic retinopathy. Turkish Journal of Medical Sciences 44, no.3 (2014): 524 - 529.
MLA Turk Adem,ESENÜLKÜ Cenap Mahmut,Akyol Nurettin,KOLA Mehmet,Erdöl Hidayet,İmamoğlu Halil İbrahim Pulsatile ocular blood flow changes after panretinal photocoagulation treatment in patients with proliferative diabetic retinopathy. Turkish Journal of Medical Sciences, vol.44, no.3, 2014, ss.524 - 529.
AMA Turk A,ESENÜLKÜ C,Akyol N,KOLA M,Erdöl H,İmamoğlu H Pulsatile ocular blood flow changes after panretinal photocoagulation treatment in patients with proliferative diabetic retinopathy. Turkish Journal of Medical Sciences. 2014; 44(3): 524 - 529.
Vancouver Turk A,ESENÜLKÜ C,Akyol N,KOLA M,Erdöl H,İmamoğlu H Pulsatile ocular blood flow changes after panretinal photocoagulation treatment in patients with proliferative diabetic retinopathy. Turkish Journal of Medical Sciences. 2014; 44(3): 524 - 529.
IEEE Turk A,ESENÜLKÜ C,Akyol N,KOLA M,Erdöl H,İmamoğlu H "Pulsatile ocular blood flow changes after panretinal photocoagulation treatment in patients with proliferative diabetic retinopathy." Turkish Journal of Medical Sciences, 44, ss.524 - 529, 2014.
ISNAD Turk, Adem vd. "Pulsatile ocular blood flow changes after panretinal photocoagulation treatment in patients with proliferative diabetic retinopathy". Turkish Journal of Medical Sciences 44/3 (2014), 524-529.