Lack of Association Between Toll-like Receptor 2 Polymorphisms (R753Q and A-16934T) and Atopic Dermatitis in Children from Thrace Region of Turkey

GÖRGÜLÜ, Adnan; SÜT, Necdet Hilmi; TOZKIR, Hilmi; CAN, Ceren; YAZICIOĞLU, GÜLFER MEHTAP; GÜRKAN, Hakan

Lack of Association Between Toll-like Receptor 2 Polymorphisms (R753Q and A-16934T) and Atopic Dermatitis in Children from Thrace Region of Turkey

Ceren CAN, (Trakya Üniversitesi, Tıp Fakültesi, Pediatrik Alerji ve İmmünoloji Ana Bilim Dalı, Edirne, Türkiye)

GÜLFER MEHTAP YAZICIOĞLU, (Trakya Üniversitesi, Tıp Fakültesi, Pediatrik Alerji ve İmmünoloji Ana Bilim Dalı, Edirne, Türkiye)

Hakan GÜRKAN, (Trakya Üniversitesi, Tıp Fakültesi, Genetik Anabilim Dalı, Edirne, Türkiye)

Hilmi TOZKIR, (Trakya Üniversitesi, Tıp Fakültesi, Genetik Anabilim Dalı, Edirne, Türkiye)

Adnan GÖRGÜLÜ, (Trakya Üniversitesi, Tıp Fakültesi, Dermatoloji Anabilim Dalı, Edirne, Türkiye)

Necdet Hilmi SÜT (Trakya Üniversitesi, Tıp Fakültesi, Biyoistatistik Anabilim Dalı, Edirne, Türkiye)

Balkan Medical Journal

1 0

Yıl: 2017 Cilt: 34 Sayı: 3 Sayfa Aralığı: 232 - 238 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Lack of Association Between Toll-like Receptor 2 Polymorphisms (R753Q and A-16934T) and Atopic Dermatitis in Children from Thrace Region of Turkey

Öz:

Background: Atopic dermatitis is the most common chronic inflammatory skin disease. A complex interaction of both genetic and environmental factors is thought to contribute to the disease. Aims: To evaluate whether single nucleotide polymorphisms in the TLR2 gene c.2258C>T (R753Q) (rs5743708) and TLR2 c.-148+1614T>A (A-16934T) (rs4696480) (NM_0032643) are associated with atopic dermatitis in Turkish children. Study Design: Case-control study. Methods: The study was conducted on 70 Turkish children with atopic dermatitis aged 0.5-18 years. The clinical severity of atopic dermatitis was evaluated by the severity scoring of atopic dermatitis index. Serum total IgE levels, specific IgE antibodies to inhalant and food allergens were measured in both atopic dermatitis patients and controls, skin prick tests were done on 70 children with atopic dermatitis. Genotyping for TLR2 (R753Q and A-16934T) single nucleotide polymorphisms was performed in both atopic dermatitis patients and controls. Results: Cytosine-cytosine and cytosin-thymine genotype frequencies of the TLR2 R753Q single nucleotide polymorphism in the atopic dermatitis group were determined as being 98.6% and 1.4%, cytosine allele frequency for TLR2 R753Q single nucleotide polymorphism was determined as 99.29% and the thymine allele frequency was 0.71%, thymine-thymine, thymineadenine, and adenine-adenine genotype frequencies of the TLR2 A-16934T single nucleotide polymorphism were 24.3%, 44.3%, and 31.4%. The thymine allele frequency for the TLR2 A-16934T single nucleotide polymorphism in the atopic dermatitis group was 46.43%, and the adenine allele frequency was 53.57%, respectively. There was not statistically significant difference between the groups for all investigated polymorphisims (p>0.05). For all single nucleotide polymorphisms studied, allelic distribution was analogous among atopic dermatitis patients and controls, and no significant statistical difference was observed. No homozygous carriers of the TLR2 R753Q single nucleotide polymorphism were found in the atopic dermatitis and control groups. Conclusion: The TLR2 (R753Q and A-16934T) single nucleotide polymorphisms are not associated with atopic dermatitis in a group of Turkish patients.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	CAN C, YAZICIOĞLU G, GÜRKAN H, TOZKIR H, GÖRGÜLÜ A, SÜT N (2017). Lack of Association Between Toll-like Receptor 2 Polymorphisms (R753Q and A-16934T) and Atopic Dermatitis in Children from Thrace Region of Turkey. , 232 - 238.
Chicago	CAN Ceren,YAZICIOĞLU GÜLFER MEHTAP,GÜRKAN Hakan,TOZKIR Hilmi,GÖRGÜLÜ Adnan,SÜT Necdet Hilmi Lack of Association Between Toll-like Receptor 2 Polymorphisms (R753Q and A-16934T) and Atopic Dermatitis in Children from Thrace Region of Turkey. (2017): 232 - 238.
MLA	CAN Ceren,YAZICIOĞLU GÜLFER MEHTAP,GÜRKAN Hakan,TOZKIR Hilmi,GÖRGÜLÜ Adnan,SÜT Necdet Hilmi Lack of Association Between Toll-like Receptor 2 Polymorphisms (R753Q and A-16934T) and Atopic Dermatitis in Children from Thrace Region of Turkey. , 2017, ss.232 - 238.
AMA	CAN C,YAZICIOĞLU G,GÜRKAN H,TOZKIR H,GÖRGÜLÜ A,SÜT N Lack of Association Between Toll-like Receptor 2 Polymorphisms (R753Q and A-16934T) and Atopic Dermatitis in Children from Thrace Region of Turkey. . 2017; 232 - 238.
Vancouver	CAN C,YAZICIOĞLU G,GÜRKAN H,TOZKIR H,GÖRGÜLÜ A,SÜT N Lack of Association Between Toll-like Receptor 2 Polymorphisms (R753Q and A-16934T) and Atopic Dermatitis in Children from Thrace Region of Turkey. . 2017; 232 - 238.
IEEE	CAN C,YAZICIOĞLU G,GÜRKAN H,TOZKIR H,GÖRGÜLÜ A,SÜT N "Lack of Association Between Toll-like Receptor 2 Polymorphisms (R753Q and A-16934T) and Atopic Dermatitis in Children from Thrace Region of Turkey." , ss.232 - 238, 2017.
ISNAD	CAN, Ceren vd. "Lack of Association Between Toll-like Receptor 2 Polymorphisms (R753Q and A-16934T) and Atopic Dermatitis in Children from Thrace Region of Turkey". (2017), 232-238.

APA	CAN C, YAZICIOĞLU G, GÜRKAN H, TOZKIR H, GÖRGÜLÜ A, SÜT N (2017). Lack of Association Between Toll-like Receptor 2 Polymorphisms (R753Q and A-16934T) and Atopic Dermatitis in Children from Thrace Region of Turkey. Balkan Medical Journal, 34(3), 232 - 238.
Chicago	CAN Ceren,YAZICIOĞLU GÜLFER MEHTAP,GÜRKAN Hakan,TOZKIR Hilmi,GÖRGÜLÜ Adnan,SÜT Necdet Hilmi Lack of Association Between Toll-like Receptor 2 Polymorphisms (R753Q and A-16934T) and Atopic Dermatitis in Children from Thrace Region of Turkey. Balkan Medical Journal 34, no.3 (2017): 232 - 238.
MLA	CAN Ceren,YAZICIOĞLU GÜLFER MEHTAP,GÜRKAN Hakan,TOZKIR Hilmi,GÖRGÜLÜ Adnan,SÜT Necdet Hilmi Lack of Association Between Toll-like Receptor 2 Polymorphisms (R753Q and A-16934T) and Atopic Dermatitis in Children from Thrace Region of Turkey. Balkan Medical Journal, vol.34, no.3, 2017, ss.232 - 238.
AMA	CAN C,YAZICIOĞLU G,GÜRKAN H,TOZKIR H,GÖRGÜLÜ A,SÜT N Lack of Association Between Toll-like Receptor 2 Polymorphisms (R753Q and A-16934T) and Atopic Dermatitis in Children from Thrace Region of Turkey. Balkan Medical Journal. 2017; 34(3): 232 - 238.
Vancouver	CAN C,YAZICIOĞLU G,GÜRKAN H,TOZKIR H,GÖRGÜLÜ A,SÜT N Lack of Association Between Toll-like Receptor 2 Polymorphisms (R753Q and A-16934T) and Atopic Dermatitis in Children from Thrace Region of Turkey. Balkan Medical Journal. 2017; 34(3): 232 - 238.
IEEE	CAN C,YAZICIOĞLU G,GÜRKAN H,TOZKIR H,GÖRGÜLÜ A,SÜT N "Lack of Association Between Toll-like Receptor 2 Polymorphisms (R753Q and A-16934T) and Atopic Dermatitis in Children from Thrace Region of Turkey." Balkan Medical Journal, 34, ss.232 - 238, 2017.
ISNAD	CAN, Ceren vd. "Lack of Association Between Toll-like Receptor 2 Polymorphisms (R753Q and A-16934T) and Atopic Dermatitis in Children from Thrace Region of Turkey". Balkan Medical Journal 34/3 (2017), 232-238.