Can a Small Intestine Segment Be an Alternative Biological Conduit for Peripheral Nerve Regeneration?

KOÇMAN, Emre A.; çetin, cengiz; ARDA, Mehmet S.; ÖZKARA, Emre; ÖZATİK, ORHAN; KOSE, AYDAN AYSE; SÖZTUTAR, ERDEM

Can a Small Intestine Segment Be an Alternative Biological Conduit for Peripheral Nerve Regeneration?

Mehmet S. ARDA, (Osmangazi Üniversitesi, Tıp Fakültesi, Çocuk Cerrahisi Anabilim Dalı, Eskişehir, Türkiye)

Emre A. KOÇMAN, (Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi, Plastik Rekonstrüktif ve Estetik Cerrahi Anabilim Dalı, Eskişehir, Türkiye)

Emre ÖZKARA, (Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi, Anatomi Anabilim Dalı, Eskişehir, Türkiye)

Erdem SÖZTUTAR, (Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi, Nöroşirurji Anabilim Dalı, Eskişehir, Türkiye)

Orhan ÖZATİK, (Ahi Evran Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Kırşehir, Türkiye)

AYDAN AYŞE KÖSE, (Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi, Plastik Rekonstrüktif ve Estetik Cerrahi Anabilim Dalı, Eskişehir, Türkiye)

Cengiz ÇETİN (Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi, Plastik Rekonstrüktif ve Estetik Cerrahi Anabilim Dalı, Eskişehir, Türkiye)

Balkan Medical Journal

1 0

Yıl: 2017 Cilt: 34 Sayı: 3 Sayfa Aralığı: 246 - 254 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Can a Small Intestine Segment Be an Alternative Biological Conduit for Peripheral Nerve Regeneration?

Öz:

Background: Autologous nerve grafts are used to bridge peripheral nerve defects. Limited sources and donor site morbidity are the major problems with peripheral nerve grafts. Although various types of autologous grafts such as arteries, veins and muscles have been recommended, an ideal conduit has not yet been described. Aims: To investigate the effectiveness of a small intestinal conduit for peripheral nerve defects. Study Design: Animal experimentation. Methods: Twenty-one rats were divided into three groups (n=7). Following anaesthesia, sciatic nerve exploration was performed in the Sham group. The 10 mm nerve gap was bridged with a 15 mm ileal segment in the small intestinal conduit group and the defect was replaced with orthotopic nerve in autologous nerve graft group. The functional recovery was tested monthly by walking-track analysis and the sciatic functional index. Histological evaluation was performed on the 12th week. Results: Sciatic functional index tests are better in autologous nerve graft group (-55.09±6.35); however, during follow-up, progress in sciatic functional index was demonstrated, along with axonal regeneration and innervation of target muscles in the small intestinal conduit group (-76.36±12.08) (p<0.05). In histologic sections, distinctive sciatic nerve regeneration was examined in the small intestinal conduit group. The expression of S-100 and neurofilament was observed in small intestinal conduit group but was less organised than in the autologous nerve graft group. Although the counted number (7459.79±1833.50 vs. 4226.51±1063.06 mm2), measured diameter [2.19 (2.15- 2.88) vs. 1.74 (1.50-2.09) µm] and myelin sheath thickness [1.18 (1.09-1.44) vs. 0.66 (0.40-1.07) µm] of axons is significantly high in the middle sections of autologous nerve graft compared to the small intestinal conduit group, respectively (p<0.05), the peripheral nerve regeneration was also observed in the small intestinal conduit group. Conclusion: Small intestinal conduit should not be considered as an alternative to autologous nerve grafts in its current form; however, the results are promising. Even though the results are no better than autologous nerve grafts, with additional procedures, it might be a good alternative due to harvesting abundant sources without donor site morbidity.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ARDA M, KOÇMAN E, ÖZKARA E, SÖZTUTAR E, ÖZATİK O, KOSE A, çetin c (2017). Can a Small Intestine Segment Be an Alternative Biological Conduit for Peripheral Nerve Regeneration?. , 246 - 254.
Chicago	ARDA Mehmet S.,KOÇMAN Emre A.,ÖZKARA Emre,SÖZTUTAR ERDEM,ÖZATİK ORHAN,KOSE AYDAN AYSE,çetin cengiz Can a Small Intestine Segment Be an Alternative Biological Conduit for Peripheral Nerve Regeneration?. (2017): 246 - 254.
MLA	ARDA Mehmet S.,KOÇMAN Emre A.,ÖZKARA Emre,SÖZTUTAR ERDEM,ÖZATİK ORHAN,KOSE AYDAN AYSE,çetin cengiz Can a Small Intestine Segment Be an Alternative Biological Conduit for Peripheral Nerve Regeneration?. , 2017, ss.246 - 254.
AMA	ARDA M,KOÇMAN E,ÖZKARA E,SÖZTUTAR E,ÖZATİK O,KOSE A,çetin c Can a Small Intestine Segment Be an Alternative Biological Conduit for Peripheral Nerve Regeneration?. . 2017; 246 - 254.
Vancouver	ARDA M,KOÇMAN E,ÖZKARA E,SÖZTUTAR E,ÖZATİK O,KOSE A,çetin c Can a Small Intestine Segment Be an Alternative Biological Conduit for Peripheral Nerve Regeneration?. . 2017; 246 - 254.
IEEE	ARDA M,KOÇMAN E,ÖZKARA E,SÖZTUTAR E,ÖZATİK O,KOSE A,çetin c "Can a Small Intestine Segment Be an Alternative Biological Conduit for Peripheral Nerve Regeneration?." , ss.246 - 254, 2017.
ISNAD	ARDA, Mehmet S. vd. "Can a Small Intestine Segment Be an Alternative Biological Conduit for Peripheral Nerve Regeneration?". (2017), 246-254.

APA	ARDA M, KOÇMAN E, ÖZKARA E, SÖZTUTAR E, ÖZATİK O, KOSE A, çetin c (2017). Can a Small Intestine Segment Be an Alternative Biological Conduit for Peripheral Nerve Regeneration?. Balkan Medical Journal, 34(3), 246 - 254.
Chicago	ARDA Mehmet S.,KOÇMAN Emre A.,ÖZKARA Emre,SÖZTUTAR ERDEM,ÖZATİK ORHAN,KOSE AYDAN AYSE,çetin cengiz Can a Small Intestine Segment Be an Alternative Biological Conduit for Peripheral Nerve Regeneration?. Balkan Medical Journal 34, no.3 (2017): 246 - 254.
MLA	ARDA Mehmet S.,KOÇMAN Emre A.,ÖZKARA Emre,SÖZTUTAR ERDEM,ÖZATİK ORHAN,KOSE AYDAN AYSE,çetin cengiz Can a Small Intestine Segment Be an Alternative Biological Conduit for Peripheral Nerve Regeneration?. Balkan Medical Journal, vol.34, no.3, 2017, ss.246 - 254.
AMA	ARDA M,KOÇMAN E,ÖZKARA E,SÖZTUTAR E,ÖZATİK O,KOSE A,çetin c Can a Small Intestine Segment Be an Alternative Biological Conduit for Peripheral Nerve Regeneration?. Balkan Medical Journal. 2017; 34(3): 246 - 254.
Vancouver	ARDA M,KOÇMAN E,ÖZKARA E,SÖZTUTAR E,ÖZATİK O,KOSE A,çetin c Can a Small Intestine Segment Be an Alternative Biological Conduit for Peripheral Nerve Regeneration?. Balkan Medical Journal. 2017; 34(3): 246 - 254.
IEEE	ARDA M,KOÇMAN E,ÖZKARA E,SÖZTUTAR E,ÖZATİK O,KOSE A,çetin c "Can a Small Intestine Segment Be an Alternative Biological Conduit for Peripheral Nerve Regeneration?." Balkan Medical Journal, 34, ss.246 - 254, 2017.
ISNAD	ARDA, Mehmet S. vd. "Can a Small Intestine Segment Be an Alternative Biological Conduit for Peripheral Nerve Regeneration?". Balkan Medical Journal 34/3 (2017), 246-254.