Kansere Karşı Koruyucu Yeni Bir Öge: Skualen

AKBULUT, GAMZE; Bozbulut, Rukiye

Kansere Karşı Koruyucu Yeni Bir Öge: Skualen

Rukiye BOZBULUT, (Gazi Üniversitesi Sağlık Araştırma ve Uygulama Merkezi, Gazi Hastanesi Beslenme ve Diyet Bölümü, Ankara, Türkiye)

Gamze AKBULUT (Gazi Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü, Ankara, Türkiye)

Beslenme ve Diyet Dergisi

27 4

Yıl: 2016 Cilt: 44 Sayı: 2 Sayfa Aralığı: 160 - 168 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Kansere Karşı Koruyucu Yeni Bir Öge: Skualen

Öz:

Akdeniz popülasyonlarında yapılan epidemiyolojik çalışmalar, zeytinyağı tüketiminin kanser riskinde azalmaya neden olduğunu göstermektedir. Zeytinyağının kanser riskini azaltıcı etkisindeki en önemli etmenlerden birinin bileşimindeki yüksek skualen içeriği olduğu düşünülmektedir. Kolesterol sentezinde bir öncü molekül olan skualen, terpenoid ailesine ait doğal bir bileşendir. Hem hayvan modellerinde, hem de in-vitro ortamlarda yapılan çalışmalarda skualenin antikanser, antioksidan, ilaç taşıyıcı, detoksifiye edici özellikleri bildirilmiştir. Son yıllarda gösterilen başlıca terapötik kullanımı çeşitli kanser türlerinde adjuvan tedavi olmasıdır. Skualen, reaktif oksijen türlerini süpürücü ajan olarak intraselüler oksidatif stresi azaltmakta ve yüksek etkili bir antioksidan olarak görev yapmaktadır. Ayrıca kanserojenik (tekli) oksijen türlerini yok ederek deri yüzeylerini lipid peroksidasyonundan korumaktadır. Deneysel çalışmalar, skualenin çeşitli kanserlerin tedavi süreçlerinde destekleyici olarak kullanılabileceğini, koruyucu etkisinin kanser tedavisi öncesi ve/veya sırasında verildiğinde gözlendiğini bildirmektedir.

Anahtar Kelime:

Konular: Beslenme ve Diyetetik

A New Item for Protection Against Cancer: Squalene

Öz:

Epidemiological studies in Mediterranean populations show that the olive oil consumption causes a reduction in cancer risk. It is considered that high content of the squalene in the olive oil is one of the most important factors in reducing the risk of cancer. Squalene, a precursor in the synthesis of cholesterol is a natural component of terpenoids family. Both in animals and in vitro studies, squalene's anticancer, antioxidant, drug carrier, detoxification features have been reported. In recent years it is shown that the main therapeutic use of squalene is an adjuvant therapy in various cancers. Squalene might reduce the intracellular oxidative stress acting as a reactive oxygen species scavenging agent and it serves as a highly effective antioxidant. It also may protect the cell from lipid peroxidation by eliminating the carcinogenic singlet oxygen species. Experimental studies report that squalene can be used as promoters in the process of treatment of various cancers, protective effect was observed when administered before and/or during the treatment of cancer.

Anahtar Kelime:

Konular: Beslenme ve Diyetetik

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	Bozbulut R, AKBULUT G (2016). Kansere Karşı Koruyucu Yeni Bir Öge: Skualen. , 160 - 168.
Chicago	Bozbulut Rukiye,AKBULUT GAMZE Kansere Karşı Koruyucu Yeni Bir Öge: Skualen. (2016): 160 - 168.
MLA	Bozbulut Rukiye,AKBULUT GAMZE Kansere Karşı Koruyucu Yeni Bir Öge: Skualen. , 2016, ss.160 - 168.
AMA	Bozbulut R,AKBULUT G Kansere Karşı Koruyucu Yeni Bir Öge: Skualen. . 2016; 160 - 168.
Vancouver	Bozbulut R,AKBULUT G Kansere Karşı Koruyucu Yeni Bir Öge: Skualen. . 2016; 160 - 168.
IEEE	Bozbulut R,AKBULUT G "Kansere Karşı Koruyucu Yeni Bir Öge: Skualen." , ss.160 - 168, 2016.
ISNAD	Bozbulut, Rukiye - AKBULUT, GAMZE. "Kansere Karşı Koruyucu Yeni Bir Öge: Skualen". (2016), 160-168.

APA	Bozbulut R, AKBULUT G (2016). Kansere Karşı Koruyucu Yeni Bir Öge: Skualen. Beslenme ve Diyet Dergisi, 44(2), 160 - 168.
Chicago	Bozbulut Rukiye,AKBULUT GAMZE Kansere Karşı Koruyucu Yeni Bir Öge: Skualen. Beslenme ve Diyet Dergisi 44, no.2 (2016): 160 - 168.
MLA	Bozbulut Rukiye,AKBULUT GAMZE Kansere Karşı Koruyucu Yeni Bir Öge: Skualen. Beslenme ve Diyet Dergisi, vol.44, no.2, 2016, ss.160 - 168.
AMA	Bozbulut R,AKBULUT G Kansere Karşı Koruyucu Yeni Bir Öge: Skualen. Beslenme ve Diyet Dergisi. 2016; 44(2): 160 - 168.
Vancouver	Bozbulut R,AKBULUT G Kansere Karşı Koruyucu Yeni Bir Öge: Skualen. Beslenme ve Diyet Dergisi. 2016; 44(2): 160 - 168.
IEEE	Bozbulut R,AKBULUT G "Kansere Karşı Koruyucu Yeni Bir Öge: Skualen." Beslenme ve Diyet Dergisi, 44, ss.160 - 168, 2016.
ISNAD	Bozbulut, Rukiye - AKBULUT, GAMZE. "Kansere Karşı Koruyucu Yeni Bir Öge: Skualen". Beslenme ve Diyet Dergisi 44/2 (2016), 160-168.