Beyindeki Mitokondriyal Eşleşme Bozucu Proteinler: Yapısı, İşlevi Ve Fizyolojik Rolleri

KIRBAĞ, Sevda; Tekin, Suat; SANDAL, Süleyman; Erden, Yavuz

Beyindeki Mitokondriyal Eşleşme Bozucu Proteinler: Yapısı, İşlevi Ve Fizyolojik Rolleri

Yavuz ERDEN, (Fırat University)

Suat TEKİN, (Department of Physiology, School of Medicine, Inonu University, Malatya, Turkey)

Sevda KIRBAĞ, (Fırat University)

Süleyman SANDAL (Department of Physiology, School of Medicine, Inonu University, Malatya, Turkey)

Medicine Science

35 1

Yıl: 2015 Cilt: 4 Sayı: 2 Sayfa Aralığı: 2289 - 2307 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Beyindeki Mitokondriyal Eşleşme Bozucu Proteinler: Yapısı, İşlevi Ve Fizyolojik Rolleri

Öz:

Mitokondriyal anyon taşıyıcı protein ailesinden olan eşleşme bozucu proteinler (UCP), farklı dokulara özgü dağılımları ve bu dokulardaki kendilerine özgü fizyolojik işlevleri nedeniyle önemlidirler. Kahverengi yağ dokuda bulunan ve bu ailenin en tanınmış üyesi olan UCP1, enerji metabolizması ile vücut sıcaklığının düzenlenmesinde görev alır. UCP ailesinin diğer üyeleri (UCP2, UCP4 ve UCP5) nöronal alanda geniş yayılım gösterir. Nöronal UCP'ler merkezi sinir sisteminde nöroendokrin fonksiyonların düzenlenmesi, serbest radikal oluşumu, nöroproteksiyon ve sinaptik iletimde görev alırlar. Bu derlemenin amacı nöronal UCP'lerin sahip olduğu fizyolojik rollerin daha iyi anlaşılmasını sağlamaktır.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Mitochondrial Uncoupling Proteins in the Brain: Their Structure, Function and Physiological Roles

Öz:

Uncoupling proteins (UCPs) which belong to mitochondrial anion carrier family are important because of their special distribution to different tissues and their intrinsic physiological function at those tissues. The UCP1 found in the brown fat tissue and being the most well-known member of this family takes in charge for arranging energy metabolism and body temperature. Other members of UCPs family (UCP2, UCP4 and UCP5) demonstrate a broad spread in neural field. Neural UCPs participate in regulating neuroendocrine functions, in forming free radicals production, in conveying neuroprotection and neurotransmission in central nervous system. The aim of this compilation is to provide a better understanding of physiological roles of neural UCPs.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	Erden Y, Tekin S, KIRBAĞ S, SANDAL S (2015). Beyindeki Mitokondriyal Eşleşme Bozucu Proteinler: Yapısı, İşlevi Ve Fizyolojik Rolleri. , 2289 - 2307.
Chicago	Erden Yavuz,Tekin Suat,KIRBAĞ Sevda,SANDAL Süleyman Beyindeki Mitokondriyal Eşleşme Bozucu Proteinler: Yapısı, İşlevi Ve Fizyolojik Rolleri. (2015): 2289 - 2307.
MLA	Erden Yavuz,Tekin Suat,KIRBAĞ Sevda,SANDAL Süleyman Beyindeki Mitokondriyal Eşleşme Bozucu Proteinler: Yapısı, İşlevi Ve Fizyolojik Rolleri. , 2015, ss.2289 - 2307.
AMA	Erden Y,Tekin S,KIRBAĞ S,SANDAL S Beyindeki Mitokondriyal Eşleşme Bozucu Proteinler: Yapısı, İşlevi Ve Fizyolojik Rolleri. . 2015; 2289 - 2307.
Vancouver	Erden Y,Tekin S,KIRBAĞ S,SANDAL S Beyindeki Mitokondriyal Eşleşme Bozucu Proteinler: Yapısı, İşlevi Ve Fizyolojik Rolleri. . 2015; 2289 - 2307.
IEEE	Erden Y,Tekin S,KIRBAĞ S,SANDAL S "Beyindeki Mitokondriyal Eşleşme Bozucu Proteinler: Yapısı, İşlevi Ve Fizyolojik Rolleri." , ss.2289 - 2307, 2015.
ISNAD	Erden, Yavuz vd. "Beyindeki Mitokondriyal Eşleşme Bozucu Proteinler: Yapısı, İşlevi Ve Fizyolojik Rolleri". (2015), 2289-2307.

APA	Erden Y, Tekin S, KIRBAĞ S, SANDAL S (2015). Beyindeki Mitokondriyal Eşleşme Bozucu Proteinler: Yapısı, İşlevi Ve Fizyolojik Rolleri. Medicine Science, 4(2), 2289 - 2307.
Chicago	Erden Yavuz,Tekin Suat,KIRBAĞ Sevda,SANDAL Süleyman Beyindeki Mitokondriyal Eşleşme Bozucu Proteinler: Yapısı, İşlevi Ve Fizyolojik Rolleri. Medicine Science 4, no.2 (2015): 2289 - 2307.
MLA	Erden Yavuz,Tekin Suat,KIRBAĞ Sevda,SANDAL Süleyman Beyindeki Mitokondriyal Eşleşme Bozucu Proteinler: Yapısı, İşlevi Ve Fizyolojik Rolleri. Medicine Science, vol.4, no.2, 2015, ss.2289 - 2307.
AMA	Erden Y,Tekin S,KIRBAĞ S,SANDAL S Beyindeki Mitokondriyal Eşleşme Bozucu Proteinler: Yapısı, İşlevi Ve Fizyolojik Rolleri. Medicine Science. 2015; 4(2): 2289 - 2307.
Vancouver	Erden Y,Tekin S,KIRBAĞ S,SANDAL S Beyindeki Mitokondriyal Eşleşme Bozucu Proteinler: Yapısı, İşlevi Ve Fizyolojik Rolleri. Medicine Science. 2015; 4(2): 2289 - 2307.
IEEE	Erden Y,Tekin S,KIRBAĞ S,SANDAL S "Beyindeki Mitokondriyal Eşleşme Bozucu Proteinler: Yapısı, İşlevi Ve Fizyolojik Rolleri." Medicine Science, 4, ss.2289 - 2307, 2015.
ISNAD	Erden, Yavuz vd. "Beyindeki Mitokondriyal Eşleşme Bozucu Proteinler: Yapısı, İşlevi Ve Fizyolojik Rolleri". Medicine Science 4/2 (2015), 2289-2307.