Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis

INANIR, AHMET; Rüstemoglu, Aydin; Nursal, Ayse Feyda; Yigit, Serbulent; TEKCAN, AKIN; Gürel, Çevik

Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis

Çevik GÜREL, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Tokat, Türkiye)

Ahmet İNANIR, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Tokat, Türkiye)

Ayşe Feyda NURSAL, (Giresun Üniversitesi, Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı, Giresun, Türkiye)

Akın TEKCAN, (Ahi Evran Üniversitesi, Sağlık Meslek Yüksekokulu, Kırşehir, Türkiye)

Aydın RÜSTEMOĞLU, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Tokat, Türkiye)

SERBÜLENT YİĞİT (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Tokat, Türkiye)

Balkan Medical Journal

1 0

Yıl: 2016 Cilt: 33 Sayı: 6 Sayfa Aralığı: 614 - 619 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis

Öz:

Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease mainly affecting the spine and sacroiliac joints. Macrophage migration inhibitory (MIF) factor is a regulatory cytokine that inhibits random immune cell migration. MIF gene promoter polymorphisms play a role in the progression of several inflammatory disorders. Aims: To investigate the relationship between the MIF gene -173 G/C single-nucleotide polymorphism (SNP) and AS. Study Design: Cross-sectional study. Methods: In this study, a total of 161 AS and 194 normal controls were recruited. The MIF gene -173 G/C SNP was analyzed by polymerase chain reaction using the restriction fragment length polymorphism method. Results: There was no significant difference between groups in terms of genotype distribution (p>0.05). When wild-type G/G and G/C+C/C genotypes are compared in terms of clinical characteristics, there is a significant difference between the average age and the duration of disease in AS patients (p<0.05). Conclusion: No significant relationship between AS disease and MIF -173 G/C polymorphism was found. MIF -173 G/C polymorphism (C allele) may affect the time of onset and the duration of disease in AS patients.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Gürel Ç, INANIR A, Nursal A, TEKCAN A, Rüstemoglu A, Yigit S (2016). Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis. , 614 - 619.
Chicago	Gürel Çevik,INANIR AHMET,Nursal Ayse Feyda,TEKCAN AKIN,Rüstemoglu Aydin,Yigit Serbulent Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis. (2016): 614 - 619.
MLA	Gürel Çevik,INANIR AHMET,Nursal Ayse Feyda,TEKCAN AKIN,Rüstemoglu Aydin,Yigit Serbulent Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis. , 2016, ss.614 - 619.
AMA	Gürel Ç,INANIR A,Nursal A,TEKCAN A,Rüstemoglu A,Yigit S Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis. . 2016; 614 - 619.
Vancouver	Gürel Ç,INANIR A,Nursal A,TEKCAN A,Rüstemoglu A,Yigit S Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis. . 2016; 614 - 619.
IEEE	Gürel Ç,INANIR A,Nursal A,TEKCAN A,Rüstemoglu A,Yigit S "Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis." , ss.614 - 619, 2016.
ISNAD	Gürel, Çevik vd. "Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis". (2016), 614-619.

APA	Gürel Ç, INANIR A, Nursal A, TEKCAN A, Rüstemoglu A, Yigit S (2016). Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis. Balkan Medical Journal, 33(6), 614 - 619.
Chicago	Gürel Çevik,INANIR AHMET,Nursal Ayse Feyda,TEKCAN AKIN,Rüstemoglu Aydin,Yigit Serbulent Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis. Balkan Medical Journal 33, no.6 (2016): 614 - 619.
MLA	Gürel Çevik,INANIR AHMET,Nursal Ayse Feyda,TEKCAN AKIN,Rüstemoglu Aydin,Yigit Serbulent Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis. Balkan Medical Journal, vol.33, no.6, 2016, ss.614 - 619.
AMA	Gürel Ç,INANIR A,Nursal A,TEKCAN A,Rüstemoglu A,Yigit S Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis. Balkan Medical Journal. 2016; 33(6): 614 - 619.
Vancouver	Gürel Ç,INANIR A,Nursal A,TEKCAN A,Rüstemoglu A,Yigit S Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis. Balkan Medical Journal. 2016; 33(6): 614 - 619.
IEEE	Gürel Ç,INANIR A,Nursal A,TEKCAN A,Rüstemoglu A,Yigit S "Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis." Balkan Medical Journal, 33, ss.614 - 619, 2016.
ISNAD	Gürel, Çevik vd. "Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis". Balkan Medical Journal 33/6 (2016), 614-619.