Correlation of Liver Enzymes and Liver Histology in Chronic Hepatitis B Virus Infection
Yıl: 2016 Cilt: 7 Sayı: 5 Sayfa Aralığı: 639 - 642 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022
Correlation of Liver Enzymes and Liver Histology in Chronic Hepatitis B Virus Infection
Öz: Amaç: Kronik HBV ile enfeksiyonu olan çocuklarda günümüzde kabul edilen ALT üst sınırının belirgin karaciğer hasarını tespit etmedeki yeterliliğini araştırmak. Gereç ve Yöntem: HBsAg (+) Kronik Hepatit B enfeksiyonu tanısı ile izlenen hastaların, demografik verileri, tanı anındaki HBV DNA ve ALT düzeyleri, karaciğer biyopsi sonuçları retrospektif olarak incelendi. Hastalar ALT düzeylerine göre grup A (ALT<40) ve B (ALT >eşit 40) olmak üzere öncelikle 2 gruba ayrıldı. Grup A daha sonra ALT <25.8 IU/L (A1) ve ALT >eşit 25.8 IU/L (A2) erkekler, ALT<22.1 IU/L (A3) ve ALT>eşit 22.1 IU/l (A4) kızlar olmak üzere 4 alt gruba ayrıldı. Histolojik aktivite indeksi >= 4 ve Fibroziz skoru >=2 belirgin hastalık kriteri olarak alındı. Histopatolojik olarak belirgin hastalık görülmüş olan ALT düzeyleri araştırıldı. Bulgular: Yaş ortalaması 10.09±3.59 yıl olan 34 hepatit B hastası çalışmaya alındı. Grup A da 18, grup B de 16 hasta mevcuttu. Her iki grubun HBV DNA düzeylerinin 3.21±4.41 vs. 1. 77±2.61 109 kopya/ml olduğu görüldü (p= 0.083). Histopatolojik olarak belirgin hastalık Grup A hastalarının %38.9'unda ve grup B hastalarının % 75'inde görüldü (p=0.045). HBV DNA düzeyleri ile HAI ve fibroziz skoru arasında korelasyon tespit edilmedi (sırasıyla r= -0.133, p=0.45 ve r= -0.259, p=0.14). Ortalama HAI ve fibroziz skoru sırasıyla 2.78±2.31 vs. 4.88±2.33 (p=0.013) ve 0.5±0.514 vs. 1.31±1.078 (p=0.007) idi. 9 grup A2 hastasından 5'inde (p=0.045) ve 4 grup A4 hastasından 2'sinde HAI >= 4 idi. Tartışma: ALT karaciğer hasarını tespit etmede kullanılabilecek iyi bir belirteçtir. Ancak çocuklarda belirgin karaciğer hasarının tespitinde eşik değerinin 40 IU/L olarak kabul edilmesi uygun değildir
Anahtar Kelime: Konular:
Kronik Hepatit B Virus Enfeksiyonunda Karaciğer Enzimleri ve Histolojisinin Korelasyonu
Öz: Aim: To evaluate the accuracy of current ALT levels in predicting histologically significant liver disease in chronic HBV infected children. Material and Method: Liver biopsies, demographic findings, HBV DNA and ALT levels of HBsAg (+) chronic hepatitis B patients were evaluated retrospectively. Patients were enrolled into group A (ALT<40) or group B (ALT>=40) and further subdivided into males with ALT <25.8 IU/L (A1) and ALT>=25.8 IU/L (A2) and females with ALT <22.1 IU/L (A3) and ALT >=22.1 IU/L (A4). Significant histology was defined as a fibrosis score >= 2 and/or histological activity index (HAI) >=4. Results: 34 patients with a mean age of 10.09±3.59 were included. There were 18 patients in group A and 16 patients in group B. Mean HBV DNA levels were 3.21±4.41 vs. 1. 77±2.61 109 copies/ml (p= 0.083). 38.9% of group A patients and 75% of group B patients had histological significant disease (p=0.045). There were no correlations between HBV DNA level and HAI and fibrosis score (respectively (r= -0.133, p=0.45) and (r= -0.259, p=0.14)). Mean histological activity index and fibrosis score were 2.78±2.31 vs. 4.88±2.33 (p=0.013) and 0.5±0.514 vs. 1.31±1.078 (p=0.007) respectively in group A and B. Five out of 9 group A2 patients (p=0.045) and 2 out of 4 group A4 patients had HAI >= 4. Discussion: ALT level is a good predictor for liver injury. But a cut-off value of 40 IU/L is not the accurate threshold in predicting liver disease probability in children
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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- How to cite this article:
- Eren M, Reyhanioglu S, Ciftci E, Dundar E, Us T, Dinleyici CE, Bor O. Correlation of Liver Enzymes and Liver Histology in Chronic Hepatitis B Virus Infection. J Clin Anal Med 2016;7(5): 639-42.
| APA | Eren M, REYHANİOGLU S, ÇİFTÇİ E, DÜNDAR E, Us T, DİNLEYİCİ C, BÖR Ö (2016). Correlation of Liver Enzymes and Liver Histology in Chronic Hepatitis B Virus Infection. , 639 - 642. |
| Chicago | Eren Makbule,REYHANİOGLU Serap,ÇİFTÇİ Evrim,DÜNDAR Emine,Us Tercan,DİNLEYİCİ Cagrı Ener,BÖR Özcan Correlation of Liver Enzymes and Liver Histology in Chronic Hepatitis B Virus Infection. (2016): 639 - 642. |
| MLA | Eren Makbule,REYHANİOGLU Serap,ÇİFTÇİ Evrim,DÜNDAR Emine,Us Tercan,DİNLEYİCİ Cagrı Ener,BÖR Özcan Correlation of Liver Enzymes and Liver Histology in Chronic Hepatitis B Virus Infection. , 2016, ss.639 - 642. |
| AMA | Eren M,REYHANİOGLU S,ÇİFTÇİ E,DÜNDAR E,Us T,DİNLEYİCİ C,BÖR Ö Correlation of Liver Enzymes and Liver Histology in Chronic Hepatitis B Virus Infection. . 2016; 639 - 642. |
| Vancouver | Eren M,REYHANİOGLU S,ÇİFTÇİ E,DÜNDAR E,Us T,DİNLEYİCİ C,BÖR Ö Correlation of Liver Enzymes and Liver Histology in Chronic Hepatitis B Virus Infection. . 2016; 639 - 642. |
| IEEE | Eren M,REYHANİOGLU S,ÇİFTÇİ E,DÜNDAR E,Us T,DİNLEYİCİ C,BÖR Ö "Correlation of Liver Enzymes and Liver Histology in Chronic Hepatitis B Virus Infection." , ss.639 - 642, 2016. |
| ISNAD | Eren, Makbule vd. "Correlation of Liver Enzymes and Liver Histology in Chronic Hepatitis B Virus Infection". (2016), 639-642. |
| APA | Eren M, REYHANİOGLU S, ÇİFTÇİ E, DÜNDAR E, Us T, DİNLEYİCİ C, BÖR Ö (2016). Correlation of Liver Enzymes and Liver Histology in Chronic Hepatitis B Virus Infection. Journal of Clinical and Analytical Medicine, 7(5), 639 - 642. |
| Chicago | Eren Makbule,REYHANİOGLU Serap,ÇİFTÇİ Evrim,DÜNDAR Emine,Us Tercan,DİNLEYİCİ Cagrı Ener,BÖR Özcan Correlation of Liver Enzymes and Liver Histology in Chronic Hepatitis B Virus Infection. Journal of Clinical and Analytical Medicine 7, no.5 (2016): 639 - 642. |
| MLA | Eren Makbule,REYHANİOGLU Serap,ÇİFTÇİ Evrim,DÜNDAR Emine,Us Tercan,DİNLEYİCİ Cagrı Ener,BÖR Özcan Correlation of Liver Enzymes and Liver Histology in Chronic Hepatitis B Virus Infection. Journal of Clinical and Analytical Medicine, vol.7, no.5, 2016, ss.639 - 642. |
| AMA | Eren M,REYHANİOGLU S,ÇİFTÇİ E,DÜNDAR E,Us T,DİNLEYİCİ C,BÖR Ö Correlation of Liver Enzymes and Liver Histology in Chronic Hepatitis B Virus Infection. Journal of Clinical and Analytical Medicine. 2016; 7(5): 639 - 642. |
| Vancouver | Eren M,REYHANİOGLU S,ÇİFTÇİ E,DÜNDAR E,Us T,DİNLEYİCİ C,BÖR Ö Correlation of Liver Enzymes and Liver Histology in Chronic Hepatitis B Virus Infection. Journal of Clinical and Analytical Medicine. 2016; 7(5): 639 - 642. |
| IEEE | Eren M,REYHANİOGLU S,ÇİFTÇİ E,DÜNDAR E,Us T,DİNLEYİCİ C,BÖR Ö "Correlation of Liver Enzymes and Liver Histology in Chronic Hepatitis B Virus Infection." Journal of Clinical and Analytical Medicine, 7, ss.639 - 642, 2016. |
| ISNAD | Eren, Makbule vd. "Correlation of Liver Enzymes and Liver Histology in Chronic Hepatitis B Virus Infection". Journal of Clinical and Analytical Medicine 7/5 (2016), 639-642. |
