Evaluation of Subclinical Inflammation withNeutrophil Lymphocyte Ratio In Heavy Metal Exposure

Gunduzoz, Meside; bal, ceylan; TUTKUN, Engin; KARAKULAK, Uğur; Yılmaz, Ömer Hinç; ERCAN KARADAĞ, MÜJGAN

Evaluation of Subclinical Inflammation withNeutrophil Lymphocyte Ratio In Heavy Metal Exposure

Ceylan BAL, (Yıldırım Beyazıt Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Ankara, Türkiye)

Uğur KARAKULAK, (Ankara Meslek Hastalıkları ve Doğum Hastanesi, Kardiyoloji Kliniği, Ankara, Türkiye)

Meside GÜNDÜZÖZ, (Meslek Hastalıkları ve Doğum Hastanesi Aile Hekimliği Anabilim Dalı, Ankara, Türkiye)

MÜJGAN ERCAN KARADAĞ, (Aydın Merkez Halk Sağlığı Laboratuvarı, Aydın, Türkiye)

Engin TUTKUN, (Ankara Mesleki Hastalıklar ve Toksikoloji Anabilim Dalı, Ankara, Türkiye)

Ömer HINÇ YILMAZ (Ankara Mesleki Hastalıklar ve Toksikoloji Anabilim Dalı, Ankara, Türkiye)

Journal of Clinical and Analytical Medicine

6 0

Yıl: 2016 Cilt: 7 Sayı: 5 Sayfa Aralığı: 643 - 647 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Evaluation of Subclinical Inflammation withNeutrophil Lymphocyte Ratio In Heavy Metal Exposure

Öz:

Amaç: Nötrofil lenfosit oranı (NLR), subklinik enflamasyon belirteci olarak sıklıkla kullanılır. Bu çalışmanın amacı, kurşun maruziyeti olan işçilerde NLR ve ağır metal seviyeleri arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntem: Kurşun maruziyeti olan 1820 bireyin demografik ve laboratuar verileri retrospektif olarak araştırıldı. C reaktif protein (CRP), eritrosit sedimentasyon hızı (ESR) ve tam kan sayımı inflamatuar belirteçler olarak değerlendirildi. Çalışmaya dahil edilen kişiler kan kurşun seviyesi < 10 ?g/dL (1. Grup), 10-30 ?g/dL (2. Grup), > 30 ?g/dL ( 3. Grup ) olacak şekilde 3 gruba ayrıldı. NLR ve kurşun arasındaki ilişki gruplar arası ve korelasyon analizi ile incelendi. Bulgular: 1., 2. ve 3. grubun NLR median değerleri sırasıyla 1. 45 (1.57), 1.90 (6.44) ve 1.96 (6.36) olarak bulundu (p<0.001). NLR kan kurşun seviyeleri ile pozitif olarak korele tespit edildi (r=0.412; p<0.001). NLR ile CRP, ESR, beyaz kan hücresi, nötrofil ve ortalama platelet hacmi seviyeleri arasında da pozitif korelasyon bulundu (sırasıyla, r=0.140; p<0.001, r=0.075; p=0.002, r=0.237; p<0.001, r=0.585; p<0.001, r=0.060; p<0.012). NLR ile lenfosit seviyeleri arasında ise negatif korelasyon elde edildi (r= -0.536; p<0.001). Tartışma: Bu çalışma, bildiğimiz kadarıyla, NLRve kurşun seviyeleri arasında güçlü ve doz bağımlı ilişkiyi gösteren ilk araştırmadır

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Ağır Metal Maruziyetinde Subklinik EnflamasyonunNötrofil Lenfosit Oranı ile Değerlendirilmesi

Öz:

Aim: Neutrophil lymphocyte ratio (NLR) is being used frequently as a marker of subclinical inflammation. The objective of this study is to investigate the association between NLR levels and heavy metal levels in workers with lead exposure. Material and Method: Demographic and laboratory data of 1820 individuals with lead exposure were evaluated retrospectively. C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and complete blood count (CBC) were evaluated as inflammatory markers. Participants were categorized into 3 groups according to blood lead levels as < 10 ?g/dL (Group 1), 10-30 ?g/dL (Group 2), and > 30 ?g/dL(Group 3). The association between NLR and lead was evaluated by inter-group and correlation analysis. Results: Median NLR values of Group 1, Group 2 and Group 3 were 1.45 (1.57), 1.90 (6.44), and 1.96 (6.36) respectively (p<0.001). NLR correlated positively with blood lead levels (r=0.412; p<0.001). A positive correlation was also detected with CRP, ESR, white blood cell (WBC), neutrophil, and mean platelet volume (MPV) levels (r=0.140; p<0.001, r=0.075; p=0.002, r=0.237; p<0.001, r=0.585; p<0.001, r=0.060; p<0.012, respectively). There was a negative correlation with lymphocyte (r= -0.536; p<0.001). Discussion: To our best knowledge, this study is the first one which shows a strong and dose-dependent association between NLR and lead levels

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	bal c, KARAKULAK U, Gunduzoz M, ERCAN KARADAĞ M, TUTKUN E, Yılmaz Ö (2016). Evaluation of Subclinical Inflammation withNeutrophil Lymphocyte Ratio In Heavy Metal Exposure. , 643 - 647.
Chicago	bal ceylan,KARAKULAK Uğur,Gunduzoz Meside,ERCAN KARADAĞ MÜJGAN,TUTKUN Engin,Yılmaz Ömer Hinç Evaluation of Subclinical Inflammation withNeutrophil Lymphocyte Ratio In Heavy Metal Exposure. (2016): 643 - 647.
MLA	bal ceylan,KARAKULAK Uğur,Gunduzoz Meside,ERCAN KARADAĞ MÜJGAN,TUTKUN Engin,Yılmaz Ömer Hinç Evaluation of Subclinical Inflammation withNeutrophil Lymphocyte Ratio In Heavy Metal Exposure. , 2016, ss.643 - 647.
AMA	bal c,KARAKULAK U,Gunduzoz M,ERCAN KARADAĞ M,TUTKUN E,Yılmaz Ö Evaluation of Subclinical Inflammation withNeutrophil Lymphocyte Ratio In Heavy Metal Exposure. . 2016; 643 - 647.
Vancouver	bal c,KARAKULAK U,Gunduzoz M,ERCAN KARADAĞ M,TUTKUN E,Yılmaz Ö Evaluation of Subclinical Inflammation withNeutrophil Lymphocyte Ratio In Heavy Metal Exposure. . 2016; 643 - 647.
IEEE	bal c,KARAKULAK U,Gunduzoz M,ERCAN KARADAĞ M,TUTKUN E,Yılmaz Ö "Evaluation of Subclinical Inflammation withNeutrophil Lymphocyte Ratio In Heavy Metal Exposure." , ss.643 - 647, 2016.
ISNAD	bal, ceylan vd. "Evaluation of Subclinical Inflammation withNeutrophil Lymphocyte Ratio In Heavy Metal Exposure". (2016), 643-647.

APA	bal c, KARAKULAK U, Gunduzoz M, ERCAN KARADAĞ M, TUTKUN E, Yılmaz Ö (2016). Evaluation of Subclinical Inflammation withNeutrophil Lymphocyte Ratio In Heavy Metal Exposure. Journal of Clinical and Analytical Medicine, 7(5), 643 - 647.
Chicago	bal ceylan,KARAKULAK Uğur,Gunduzoz Meside,ERCAN KARADAĞ MÜJGAN,TUTKUN Engin,Yılmaz Ömer Hinç Evaluation of Subclinical Inflammation withNeutrophil Lymphocyte Ratio In Heavy Metal Exposure. Journal of Clinical and Analytical Medicine 7, no.5 (2016): 643 - 647.
MLA	bal ceylan,KARAKULAK Uğur,Gunduzoz Meside,ERCAN KARADAĞ MÜJGAN,TUTKUN Engin,Yılmaz Ömer Hinç Evaluation of Subclinical Inflammation withNeutrophil Lymphocyte Ratio In Heavy Metal Exposure. Journal of Clinical and Analytical Medicine, vol.7, no.5, 2016, ss.643 - 647.
AMA	bal c,KARAKULAK U,Gunduzoz M,ERCAN KARADAĞ M,TUTKUN E,Yılmaz Ö Evaluation of Subclinical Inflammation withNeutrophil Lymphocyte Ratio In Heavy Metal Exposure. Journal of Clinical and Analytical Medicine. 2016; 7(5): 643 - 647.
Vancouver	bal c,KARAKULAK U,Gunduzoz M,ERCAN KARADAĞ M,TUTKUN E,Yılmaz Ö Evaluation of Subclinical Inflammation withNeutrophil Lymphocyte Ratio In Heavy Metal Exposure. Journal of Clinical and Analytical Medicine. 2016; 7(5): 643 - 647.
IEEE	bal c,KARAKULAK U,Gunduzoz M,ERCAN KARADAĞ M,TUTKUN E,Yılmaz Ö "Evaluation of Subclinical Inflammation withNeutrophil Lymphocyte Ratio In Heavy Metal Exposure." Journal of Clinical and Analytical Medicine, 7, ss.643 - 647, 2016.
ISNAD	bal, ceylan vd. "Evaluation of Subclinical Inflammation withNeutrophil Lymphocyte Ratio In Heavy Metal Exposure". Journal of Clinical and Analytical Medicine 7/5 (2016), 643-647.