Ceylan BAL
(Yıldırım Beyazıt Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Ankara, Türkiye)
Uğur KARAKULAK
(Ankara Meslek Hastalıkları ve Doğum Hastanesi, Kardiyoloji Kliniği, Ankara, Türkiye)
Meside GÜNDÜZÖZ
(Meslek Hastalıkları ve Doğum Hastanesi Aile Hekimliği Anabilim Dalı, Ankara, Türkiye)
MÜJGAN ERCAN KARADAĞ
(Aydın Merkez Halk Sağlığı Laboratuvarı, Aydın, Türkiye)
ENGİN TUTKUN
(Ankara Mesleki Hastalıklar ve Toksikoloji Anabilim Dalı, Ankara, Türkiye)
ÖMER HINÇ YILMAZ
(Ankara Mesleki Hastalıklar ve Toksikoloji Anabilim Dalı, Ankara, Türkiye)
Yıl: 2016Cilt: 7Sayı: 5ISSN: 1309-2014Sayfa Aralığı: 643 - 647İngilizce

99 5
Evaluation of Subclinical Inflammation withNeutrophil Lymphocyte Ratio In Heavy Metal Exposure
Amaç: Nötrofil lenfosit oranı (NLR), subklinik enflamasyon belirteci olarak sıklıkla kullanılır. Bu çalışmanın amacı, kurşun maruziyeti olan işçilerde NLR ve ağır metal seviyeleri arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntem: Kurşun maruziyeti olan 1820 bireyin demografik ve laboratuar verileri retrospektif olarak araştırıldı. C reaktif protein (CRP), eritrosit sedimentasyon hızı (ESR) ve tam kan sayımı inflamatuar belirteçler olarak değerlendirildi. Çalışmaya dahil edilen kişiler kan kurşun seviyesi < 10 ?g/dL (1. Grup), 10-30 ?g/dL (2. Grup), > 30 ?g/dL ( 3. Grup ) olacak şekilde 3 gruba ayrıldı. NLR ve kurşun arasındaki ilişki gruplar arası ve korelasyon analizi ile incelendi. Bulgular: 1., 2. ve 3. grubun NLR median değerleri sırasıyla 1. 45 (1.57), 1.90 (6.44) ve 1.96 (6.36) olarak bulundu (p<0.001). NLR kan kurşun seviyeleri ile pozitif olarak korele tespit edildi (r=0.412; p<0.001). NLR ile CRP, ESR, beyaz kan hücresi, nötrofil ve ortalama platelet hacmi seviyeleri arasında da pozitif korelasyon bulundu (sırasıyla, r=0.140; p<0.001, r=0.075; p=0.002, r=0.237; p<0.001, r=0.585; p<0.001, r=0.060; p<0.012). NLR ile lenfosit seviyeleri arasında ise negatif korelasyon elde edildi (r= -0.536; p<0.001). Tartışma: Bu çalışma, bildiğimiz kadarıyla, NLRve kurşun seviyeleri arasında güçlü ve doz bağımlı ilişkiyi gösteren ilk araştırmadır
Fen > Tıp > Genel ve Dahili Tıp
DergiAraştırma MakalesiErişime Açık
  • 1. Cooper GS, Makris SL, Nietert PJ, Jinot J. Evidence of autoimmune-related effects of trichloroethylene exposure from studies in mice and humans. Environ Health Perspect 2009;117(5):696-702.
  • 2. Chiu WA, Caldwell JC, Keshava N, Scott CS. Key scientific issues in the health risk assessment of trichloroethylene. Environ Health Perspect2006;114(9):1445-9.
  • 3. Wu C, Schaum J. Exposure assessment of trichloroethylene. Environ Health Perspect 2006;114(9):1445-9.
  • 4. Ekong EB, Jaar BG, Weaver VM. Lead-related nephrotoxicity. A review of the epidemiologic evidence. Kidney Int 2006;70(12):2074-84.
  • 5. Palus J, Rydzynski K, Dziubaltowska E, Wyszynska K, Natarajan AT, Nilsson R. Genotoxic effects of occupational exposure to lead and cadmium. Mutat Res 2003;540(1):19-28.
  • 6. Flora SJ, Mittal M, Mehta A. Heavy metal induced oxidative stress & its possible reversal by chelation therapy. Indian J Med Res 2008;128(4):501-23.
  • 7. Gomez D, Farid S, Malik HZ, Young AL, Lodge JP, Prasad KR. Preoperative neutrophil- to-lymphocyte ratio as a prognostic predictor after curative resection for hepatocellular carcinoma. World J Surg 2008;32(8):1757-62.
  • 8. Azab B, Bhatt VR, Phookan J, Murukutla S, Kohn N, Widmann WD. Usefulness of the neutrophil-to-lymphocyte ratio in predicting short- and long-term mortality in breast cancer patients. Ann Surg Oncol 2012;19(1):217-24.
  • 9. Alan H. B. Wu.Tietz Clinical Guide to Laboratory Tests, 4th Edition, San Francisco, California, USA; 2005 pp. 658
  • 10. Ramesh GT, Manna SK, Aggarwal BB, Jadhav AL. Lead exposure activates nuclear factor kappa b, activator protein-1, c-jun n-terminal kinase and caspases in the rat brain. Toxicol Lett 2001;123(2-3):195-207.
  • 11. Vaziri ND, Khan M. Interplay of reactive oxygen species and nitric oxide in the pathogenesis of experimental lead-induced hypertension. Clin Exp Pharmacol Physiol 2007;34(9):920-5.
  • 12. Gurer-Orhan H, Sabir HU, Ozgunes H. Correlation between clinical indicators of lead poisoning and oxidative stress parameters in controls and lead-exposed workers. Toxicology 2004;195(2-3):147-54.
  • 13. Sirivarasai J, Wananukul W, Kaojarern S, Chanprasertyothin S, Thongmung N, Ratanachaiwong W et al. Association between inflammatory marker, environmental lead exposure, and glutathione s-transferase gene. Biomed Res Int 2013;2013:474963.
  • 14. Iavicoli I, Carelli G, Stanek EJ, Castellino N, Calabrese EJ. Below background levels of blood lead impact cytokine levels in male and female mice. Toxicol Appl Pharmacol 2006;210(1-2):94-9.
  • 15. Hunaiti A, Soud M, Khalil A. Lead concentration and the level of glutathione, glutathiones-transferase, reductase and peroxidase in the blood of some occupational workers from Irbid city, Jordan. Sci Total Environ 1995;170(1-2):95-100.
  • 16. Patrick L. Lead toxicity part ii. The role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity. Altern Med Rev 2006;11(2):114-27.
  • 17. Kim JH, Lee KH, Yoo DH, Kang D, Cho SH, Hong YC. Gstm1 and TNF-alpha gene polymorphisms and relations between blood lead and inflammatory markers in a non-occupational population. Mutation Research 2007;629(1):32-9.
  • 18. Khan DA, Qayyum S, Saleem S, Khan FA. Lead-induced oxidative stress adversely affects health of the occupational workers. Toxicol Ind Health. 2008;24(9):611-8.
  • 19. Farkhondeh T, Boskabady MH, Koohi MK, Sadeghi-Hashjin G, Moin M. The effect of lead exposure on selected blood inflammatory biomarkers in guinea pigs. Cardiovasc Hematol Disord Drug Targets 2013;13(1):45-9.
  • 20. Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. The New England Journal of Medicine 2003;348(2):138-50.
  • 21. Rossi-George A, Virgolini MB, Weston D, Cory-Slechta DA. Alterations in glucocorticoid negative feedback following maternal pb, prenatal stress and the combination: A potential biological unifying mechanism for their corresponding disease profiles. Toxicol Appl Pharmacol 2009;234(1):117-27.
  • 22. Virgolini MB, Rossi-George A, Weston D, Cory-Slechta DA. Influence of low level maternal pb exposure and prenatal stress on offspring stress challenge responsivity. Neurotoxicology 2008; 29(6):928-39.
  • 23. Fortin MC, Cory-Slechta DA, Ohman-Strickland P, Nwankwo C, Yanger TS, Todd AC, et al. Increased lead biomarker levels are associated with changes in hormonal response to stress in occupationally exposed male participants. Environ Health Perspect 2012;120(2):278-83.
  • 24. Gump BB, Stewart P, Reihman J, Lonky E, Darvill T, Parsons PJ, et al. Low-level prenatal and postnatal blood lead exposure and adrenocortical responses to acute stress in children.Environ Health Perspect 2008;116(2):249-55.
  • 25. Lawrence DA: In vivo and in vitro effects of lead on humoral and cell-mediated immunity. Infection and immunity 1981;31(1):136-143.

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