Insulin Like Growth Factor System: How Does it Affect Neonatal Anthropometry?

KANAT PEKTAS, Mine; ÖZER, Alev; serin, salih; TOLUN İNANÇ, Fatma; Kacar, Emine; GÜMÜŞALAN, Yakup

Insulin Like Growth Factor System: How Does it Affect Neonatal Anthropometry?

Emine KAÇAR, (Kahramanmaraş Sütçü İmam Üniversitesi, Tıp Fakültesi, Anatomi Anabilim Dalı, Kahramanmaraş, Türkiye)

Alev ÖZER, (Kahramanmaraş Sütçü İmam Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Kahramanmaraş, Türkiye)

Salih SERİN, (Tatvan Devlet Hastanesi, Kadın Hastalıkları ve Doğum Kliniği, Bitlis, Türkiye)

Yakup GÜMÜŞALAN, (Fatih Üniversitesi, Tıp Fakültesi, Anatomi Anabilim Dalı, Ankara, Türkiye)

Fatma TOLUN İNANÇ, (Kahramanmaraş Sütçü İmam Üniversitesi, Tıp Fakültesi, Biyokimya Bölümü, Kahramanmaraş, Türkiye)

Mine KANAT PEKTAS (Afyon Kocatepe Üniversitesi, Veteriner Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Afyonkarahisar, Türkiye)

Journal of Clinical and Analytical Medicine

1 0

Yıl: 2016 Cilt: 7 Sayı: 5 Sayfa Aralığı: 664 - 667 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Insulin Like Growth Factor System: How Does it Affect Neonatal Anthropometry?

Öz:

Amaç: İnsülin benzeri büyüme faktörü-1 (IGF-1), insulin benzeri büyüme faktörü bağlayıcı proteini-3 (IGFBP-3), insulin ve ghrelinin fetal büyümedeki rolünün değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Türk standartları kullanılarak 60 yenidoğan bebek, gestasyonel yaşa göre küçük (SGA) (n=14), gestasyonel yaşa uygun (AGA) (n=33) ve gestasyonel yaşa göre büyük (LGA) (n=13) olarak gruplandırıldı. Maternal serumda ve umbilikal kordon kanında IGF-1, IGFBP-3, ghrelin, and insulin düzeyleri ölçüldü. Bulgular: SGA grubuyla karşılaştırıldığında, LGA grubunda maternal serum ve umbilikal kordon kanındaki IGF-1, IGFBP-3, ghrelin, and insulin düzeyleri anlamlı olarak yüksekti Hem maternal serumdaki hem umbilikal kord kanındaki IGF-1 ve IGFBP-3 düzeylerinin yenidoğanların ağırlığı ve uzunluğuyla, kafa ve karın çevresi ölçümleriyle istatistiksel olarak anlamlı ve pozitif korelasyon gösterdiği saptandı.Tartışma: Bu çalışmadan elde edilen bulgular, insülin benzeri büyüme faktörü sisteminin fetal büyümede rol aldığını düşündürmektedir

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

İnsülin Benzeri Büyüme Faktörü Sistemi Neonatal Antropometriyi Nasıl Etkilemektedir

Öz:

Aim: The present study aims to clarify the role of insulin like growth factor-1 (IGF-1), insulin like growth factor binding protein-3 (IGFBP-3), ghrelin, and insulin in fetal growth. Material and Method: Based on Turkish standards, 14 newborns were defined as small for gestational age (SGA), 33 newborns were described as appropriate for gestational age (AGA), and 13 newborns were identified as large for gestational age (LGA). IGF-1, IGFBP-3, ghrelin, and insulin levels were measured in umbilical cord and maternal serum. Results: The LGA group had significantly higher levels of IGF-1, IGFBP-3, ghrelin, and insulin in umbilical cord and maternal serum than the SGA group. Umbilical cord and maternal serum levels of IGF-1 and IGFBP-3 correlated significantly and positively with body weight, body length, head circumference, and abdominal circumference of the neonates. Discussion: Based on the findings of the present study, it may be postulated that insulin like growth factor system has a role in fetal growth

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Kacar E, ÖZER A, serin s, GÜMÜŞALAN Y, TOLUN İNANÇ F, KANAT PEKTAS M (2016). Insulin Like Growth Factor System: How Does it Affect Neonatal Anthropometry?. , 664 - 667.
Chicago	Kacar Emine,ÖZER Alev,serin salih,GÜMÜŞALAN Yakup,TOLUN İNANÇ Fatma,KANAT PEKTAS Mine Insulin Like Growth Factor System: How Does it Affect Neonatal Anthropometry?. (2016): 664 - 667.
MLA	Kacar Emine,ÖZER Alev,serin salih,GÜMÜŞALAN Yakup,TOLUN İNANÇ Fatma,KANAT PEKTAS Mine Insulin Like Growth Factor System: How Does it Affect Neonatal Anthropometry?. , 2016, ss.664 - 667.
AMA	Kacar E,ÖZER A,serin s,GÜMÜŞALAN Y,TOLUN İNANÇ F,KANAT PEKTAS M Insulin Like Growth Factor System: How Does it Affect Neonatal Anthropometry?. . 2016; 664 - 667.
Vancouver	Kacar E,ÖZER A,serin s,GÜMÜŞALAN Y,TOLUN İNANÇ F,KANAT PEKTAS M Insulin Like Growth Factor System: How Does it Affect Neonatal Anthropometry?. . 2016; 664 - 667.
IEEE	Kacar E,ÖZER A,serin s,GÜMÜŞALAN Y,TOLUN İNANÇ F,KANAT PEKTAS M "Insulin Like Growth Factor System: How Does it Affect Neonatal Anthropometry?." , ss.664 - 667, 2016.
ISNAD	Kacar, Emine vd. "Insulin Like Growth Factor System: How Does it Affect Neonatal Anthropometry?". (2016), 664-667.

APA	Kacar E, ÖZER A, serin s, GÜMÜŞALAN Y, TOLUN İNANÇ F, KANAT PEKTAS M (2016). Insulin Like Growth Factor System: How Does it Affect Neonatal Anthropometry?. Journal of Clinical and Analytical Medicine, 7(5), 664 - 667.
Chicago	Kacar Emine,ÖZER Alev,serin salih,GÜMÜŞALAN Yakup,TOLUN İNANÇ Fatma,KANAT PEKTAS Mine Insulin Like Growth Factor System: How Does it Affect Neonatal Anthropometry?. Journal of Clinical and Analytical Medicine 7, no.5 (2016): 664 - 667.
MLA	Kacar Emine,ÖZER Alev,serin salih,GÜMÜŞALAN Yakup,TOLUN İNANÇ Fatma,KANAT PEKTAS Mine Insulin Like Growth Factor System: How Does it Affect Neonatal Anthropometry?. Journal of Clinical and Analytical Medicine, vol.7, no.5, 2016, ss.664 - 667.
AMA	Kacar E,ÖZER A,serin s,GÜMÜŞALAN Y,TOLUN İNANÇ F,KANAT PEKTAS M Insulin Like Growth Factor System: How Does it Affect Neonatal Anthropometry?. Journal of Clinical and Analytical Medicine. 2016; 7(5): 664 - 667.
Vancouver	Kacar E,ÖZER A,serin s,GÜMÜŞALAN Y,TOLUN İNANÇ F,KANAT PEKTAS M Insulin Like Growth Factor System: How Does it Affect Neonatal Anthropometry?. Journal of Clinical and Analytical Medicine. 2016; 7(5): 664 - 667.
IEEE	Kacar E,ÖZER A,serin s,GÜMÜŞALAN Y,TOLUN İNANÇ F,KANAT PEKTAS M "Insulin Like Growth Factor System: How Does it Affect Neonatal Anthropometry?." Journal of Clinical and Analytical Medicine, 7, ss.664 - 667, 2016.
ISNAD	Kacar, Emine vd. "Insulin Like Growth Factor System: How Does it Affect Neonatal Anthropometry?". Journal of Clinical and Analytical Medicine 7/5 (2016), 664-667.