Association Between Postoperative Hypoalbuminemia and Complications in Ovarian Carcinoma

Meydanli, Mehmet Mutlu; AKSOY, Emin Levent; ÇETİNKAYA, Nilüfer; GÖKHAN DURMUŞ, Eyüp; ÖZ, Murat; Ersak, Burak

Association Between Postoperative Hypoalbuminemia and Complications in Ovarian Carcinoma

Murat ÖZ, (Dr. Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi, Ankara, Türkiye)

Emin Levent AKSOY, (Dr. Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi, Ankara, Türkiye)

Nilüfer ÇETİNKAYA, (Dr. Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi, Ankara, Türkiye)

Eyüp GÖKHAN DURMUŞ, (Dr. Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi, Ankara, Türkiye)

Burak ERSAK, (Dr. Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi, Ankara, Türkiye)

Mehmet Mutlu MEYDANLI (Dr. Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi, Ankara, Türkiye)

Journal of Clinical and Analytical Medicine

9 0

Yıl: 2016 Cilt: 7 Sayı: 5 Sayfa Aralığı: 686 - 689 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Association Between Postoperative Hypoalbuminemia and Complications in Ovarian Carcinoma

Öz:

Amaç: Yaş, performans durumu, cerrahi radikalite, nutrisyonel durum ve serum albumin düzeyi gibi birçok durum, artmış postoperatif komplikasyon için risk faktörü olarak tanımlanmıştır. Mevcut çalişmamızda amaç, postoperatif serum albumin düzeylerinin postoperatif komplikasyonlar üzerindeki etkisini araştırmaktır. Gereç ve Yöntem: Borderline over tümörü ya da invaziv over kanseri tanısı ile debulking cerrahisi yapılan hastalara ait veriler retrospektif olarak toplandı. Hafif hipoalbuminemi için eşik değer 3.5 g/dl, şiddetli hipoalbuminemi için eşik değer 2.5 g/dl olarak tanımlandı. Bulgular: Tarif edilen süre içerisinde debulking cerrahisi yapılan toplam 200 hasta tanımlandı. Şiddetli hipoalbuminemisi olan hastalarda daha fazla oranda ciddi komplikasyon izlendi (p<0.05, OR 2.6; 95% CI: 0.7-9.1). Ortalama diseke edilen lenf nodu sayıları şiddetli hipoalbuminemi, hafif hipoalbuminemi ve normal albumin seviyesine sahip hastalarda sırası ile 57.2, 49.4 ve 45.5 olarak tespit edildi (p<0.05). Şiddetli hipoalbuminemisi olan hastaların ortalama hastanede yatış süreleri (10.26 gün) ve yoğun bakımda kalış süreleri (1.5 gün), hafif hipoalbuminemisi olan hastalardan (sırası ile 9.3 gün ve 1.3 gün) ve normal albumin düzeylerine sahip hastalardan (sırasıyla 8.2 gün ve 1.2 gün) anlamlı olarak daha fazla idi (p<0.05). Şiddetli hipoalbuminemisi olan hastaların %60'ında, hafif hipoalbuminemisi olan hastaların %42.4'sinde ve normal albumin düzeylerine sahip hastaların %20'sinde eritrosit süspansiyonu transfüzyonu ihtiyacı olmuştur. Tartışma: Sonuç olarak, postoperatif hipoalbuminemi saptanan hastalar ciddi postoperatif komplikasyonlar açısından yüksek risklidir ve postoperatif dönemde daha yakın takip gereksinimleri olabilir

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Over Kanserinde Postoperatif Hipoalbuminemi ile Postoperatif Komplikasyonların İlişkisi

Öz:

Aim: Several factors have been described as risk factors for increased postoperative complications, such as age, performance status, surgical aggressiveness, nutritional status, and serum albumin levels. The aim of the present study is to evaluate the predictive role of postoperative serum albumin levels on postoperative complications. Material and Method: Data of patients with the diagnosis of borderline ovarian tumors or invasive ovarian cancer and who had undergone debulking surgery were retrieved retrospectively. We defined the cut-off value of 3.5 g/dl for mild hypoalbuminemia and 2.5 g/dl for severe hypoalbuminemia. Results: A total of 200 patients were identified, all of whom had undergone debulking surgery at our hospital in the time period from January 2008 to December 2015. Patients with severe postoperative hypoalbuminemia had higher incidences of severe postoperative complications (CDC grade >=2) (p<0.05, OR 2.6; 95% CI: 0.7-9.1). Mean dissected lymph node counts for patients with severe hypoalbuminemia, mild hypoalbuminemia, and normal albumin levels were 57.2, 49.4, and 45.5, respectively (P<0.05). Patients with severe hypoalbuminemia had longer hospital stays (mean 10.26 days) and ICU stays (mean 1.5 days) compared to patients with mild hypoalbuminemia (9.3 and 1.3 days, respectively) and those with normal albumin levels (8.2 and 1.2 days, respectively) (p<0.05). Sixty percent of the patients with severe hypoalbuminemia, 42.4% of the patients with mild hypoalbuminemia, and 20% of the patients with normal albumin levels needed at least one unit of packed RBC transfusion in the per-operative period. Discussion: Patients with postoperative hypoalbuminemia have an increased risk of serious postoperative complications and they should be more closely followed during the early postoperative course

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÖZ M, AKSOY E, ÇETİNKAYA N, GÖKHAN DURMUŞ E, Ersak B, Meydanli M (2016). Association Between Postoperative Hypoalbuminemia and Complications in Ovarian Carcinoma. , 686 - 689.
Chicago	ÖZ Murat,AKSOY Emin Levent,ÇETİNKAYA Nilüfer,GÖKHAN DURMUŞ Eyüp,Ersak Burak,Meydanli Mehmet Mutlu Association Between Postoperative Hypoalbuminemia and Complications in Ovarian Carcinoma. (2016): 686 - 689.
MLA	ÖZ Murat,AKSOY Emin Levent,ÇETİNKAYA Nilüfer,GÖKHAN DURMUŞ Eyüp,Ersak Burak,Meydanli Mehmet Mutlu Association Between Postoperative Hypoalbuminemia and Complications in Ovarian Carcinoma. , 2016, ss.686 - 689.
AMA	ÖZ M,AKSOY E,ÇETİNKAYA N,GÖKHAN DURMUŞ E,Ersak B,Meydanli M Association Between Postoperative Hypoalbuminemia and Complications in Ovarian Carcinoma. . 2016; 686 - 689.
Vancouver	ÖZ M,AKSOY E,ÇETİNKAYA N,GÖKHAN DURMUŞ E,Ersak B,Meydanli M Association Between Postoperative Hypoalbuminemia and Complications in Ovarian Carcinoma. . 2016; 686 - 689.
IEEE	ÖZ M,AKSOY E,ÇETİNKAYA N,GÖKHAN DURMUŞ E,Ersak B,Meydanli M "Association Between Postoperative Hypoalbuminemia and Complications in Ovarian Carcinoma." , ss.686 - 689, 2016.
ISNAD	ÖZ, Murat vd. "Association Between Postoperative Hypoalbuminemia and Complications in Ovarian Carcinoma". (2016), 686-689.

APA	ÖZ M, AKSOY E, ÇETİNKAYA N, GÖKHAN DURMUŞ E, Ersak B, Meydanli M (2016). Association Between Postoperative Hypoalbuminemia and Complications in Ovarian Carcinoma. Journal of Clinical and Analytical Medicine, 7(5), 686 - 689.
Chicago	ÖZ Murat,AKSOY Emin Levent,ÇETİNKAYA Nilüfer,GÖKHAN DURMUŞ Eyüp,Ersak Burak,Meydanli Mehmet Mutlu Association Between Postoperative Hypoalbuminemia and Complications in Ovarian Carcinoma. Journal of Clinical and Analytical Medicine 7, no.5 (2016): 686 - 689.
MLA	ÖZ Murat,AKSOY Emin Levent,ÇETİNKAYA Nilüfer,GÖKHAN DURMUŞ Eyüp,Ersak Burak,Meydanli Mehmet Mutlu Association Between Postoperative Hypoalbuminemia and Complications in Ovarian Carcinoma. Journal of Clinical and Analytical Medicine, vol.7, no.5, 2016, ss.686 - 689.
AMA	ÖZ M,AKSOY E,ÇETİNKAYA N,GÖKHAN DURMUŞ E,Ersak B,Meydanli M Association Between Postoperative Hypoalbuminemia and Complications in Ovarian Carcinoma. Journal of Clinical and Analytical Medicine. 2016; 7(5): 686 - 689.
Vancouver	ÖZ M,AKSOY E,ÇETİNKAYA N,GÖKHAN DURMUŞ E,Ersak B,Meydanli M Association Between Postoperative Hypoalbuminemia and Complications in Ovarian Carcinoma. Journal of Clinical and Analytical Medicine. 2016; 7(5): 686 - 689.
IEEE	ÖZ M,AKSOY E,ÇETİNKAYA N,GÖKHAN DURMUŞ E,Ersak B,Meydanli M "Association Between Postoperative Hypoalbuminemia and Complications in Ovarian Carcinoma." Journal of Clinical and Analytical Medicine, 7, ss.686 - 689, 2016.
ISNAD	ÖZ, Murat vd. "Association Between Postoperative Hypoalbuminemia and Complications in Ovarian Carcinoma". Journal of Clinical and Analytical Medicine 7/5 (2016), 686-689.