Yıl: 2016 Cilt: 7 Sayı: 5 Sayfa Aralığı: 706 - 710 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Evaluation of Platelet Indices in Young Male Patients with Hepatitis C

Öz:
Amaç: Hepatit C virüs (HCV) enfeksiyonu olan hastalarda enflamasyon ve fibrozisin şiddetine bağlı olarak platelet sayısı ve boyutlarının değişebileceği gerçeği doğrultusunda, HCV enfeksiyonu olan erkek hastalarda sağlıklı kontrol grubuna kıyasla platelet parametrelerinin ve platelet-lenfosit oranı (PLR) seviyelerini ve önemini araştırmayı amaçladık. Gereç ve Yöntem: 01 Ocak 2012 ve 01 Haziran 2015 tarihleri arasında Enfeksiyon Hastalıkları polikliniğine HCV enfeksiyonu nedeniyle müracaat eden hastaların dosyaları geriye dönük olarak değerlendirildi. Karaciğer biyopsisi olmuş 21 erkek hasta ile cinsiyet ve yaş uyumlu 22 sağlıklı kontrol çalışmaya dahil edildi. İstatiksel analizler SPSS 15.0 programı ile yapıldı. Bulgular: Hasta grubu (ortalama yaş=24.62±5.84 yıl ve yaş aralığı=21-41 yıl) ve kontrol grubu (ortalama yaş=24.59±5.21 yıl ve yaş aralığı=21-41 yıl) arasında yaş değişkeni açısından anlamlı farklılık yoktu. Hastaların %23.8'inde fibrozis skoru 1, %61.9'unda fibrozis skoru 2 ve sadece %14.3'ünde fibrozis skoru 3 olarak belirlendi. Kontrol grubuna göre hasta grubunda, lenfosit sayıları, platelet sayıları, PLR, plateletcrit ve platelet hacmi dağılım genişliği düşük ve ortalama platelet hacmi (MPV) daha yüksek olsa da, iki grup arasında istatiksel olarak anlamlı farklılık yoktu. Ayrıca, platelet sayıları, platelet parametreleri ve PLR değerleri açısından fibrozis skoruna ve histolojik aktivite indeksi skoruna göre hasta grupları arasında da anlamlı farklılık yoktu. Tartışma: Çalışmamız sonucunda HCV enfeksiyonuna bağlı minimal ve orta derecede fibrozisi olan genç yetişkin erkek hastalarda, platelet sayıları, platelet parametreleri ve PLR değerlerinde anlamlı olmayan minimal bir etkilenme tespit edildi. Bununla birlikte, platelet sayılarının daha düşük beklendiği ilerlemiş fibrozisi veya sirozu olan hastalarda, platelet parametrelerinin önemi artabilir
Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Hepatit C Enfeksiyonu Olan Genç Erkek Hastalarda Platelet Parametrelerinin Değerlendirilmesi

Öz:
Aim: In light of the fact that platelet counts and sizes or lymphocyte counts may be altered in patients with hepatitis C virus (HCV) depending upon the severity of inflammation or fibrosis, we aimed to investigate the values and the roles of platelet indices and platelet-to-lymphocyte ratio (PLR) in male patients with HCV infection compared with healthy controls. Material and Method: Patients with HCV infection who applied to an Infectious Diseases clinic between 01 January 2012 and 01 June 2015 were evaluated retrospectively. Overall, 21 male HCV patients who underwent percutaneous liver biopsy and 22 gender-and age- matched healthy controls were included in the study. Statistical analyses were performed by SPSS 15.0. Results: There was no significant difference in age variable between the patients group with an age range of 21-41 years [22 (Iq=4), 24.62±5.84 years] and the control group with an age range of 21-41 years [22,5 (Iq=5), 24.59±5.21 years]. The distribution of fibrosis scores among HCV patients was 23.8% fibrosis score 1, 61.9% fibrosis score 2, and only 14.3% fibrosis score 3. Lymphocyte counts, platelet counts, PLR, platelet volume, distribution width, and plateletcrit values were lower, and mean platelet volume (MPV) values were higher, in the patients group compared with controls, but there was no statistical difference between the two groups. There was also no significant difference in platelet counts, platelet indices, or PLR values between groups according to the fibrosis scores or according to the histological activity index (HAI) score. Discussion: In our study, there were minimally but not significantly affected platelet counts, platelet indices, and PLR values in young adult male patients with minimal or moderate fibrosis induced by HCV infection. However, in patients with advanced liver fibrosis or cirrhosis whose platelet counts may be lower, platelet indices may increase in importance
Anahtar Kelime:

Konular: Genel ve Dahili Tıp
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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  • How to cite this article:
  • Afyon M, Artuk C, Yenilmez E, Şimşek B, Kaya A. Evaluation of Platelet Incides in
  • Young Male Patients with Hepatitis C. J Clin Anal Med 2016;7(5): 706-10.
APA AFYON M, ARTUK C, Yenilmez E, ŞİMŞEK B, KAYA A (2016). Evaluation of Platelet Indices in Young Male Patients with Hepatitis C. , 706 - 710.
Chicago AFYON Murat,ARTUK CUMHUR,Yenilmez Ercan,ŞİMŞEK Berksan,KAYA Ayper Evaluation of Platelet Indices in Young Male Patients with Hepatitis C. (2016): 706 - 710.
MLA AFYON Murat,ARTUK CUMHUR,Yenilmez Ercan,ŞİMŞEK Berksan,KAYA Ayper Evaluation of Platelet Indices in Young Male Patients with Hepatitis C. , 2016, ss.706 - 710.
AMA AFYON M,ARTUK C,Yenilmez E,ŞİMŞEK B,KAYA A Evaluation of Platelet Indices in Young Male Patients with Hepatitis C. . 2016; 706 - 710.
Vancouver AFYON M,ARTUK C,Yenilmez E,ŞİMŞEK B,KAYA A Evaluation of Platelet Indices in Young Male Patients with Hepatitis C. . 2016; 706 - 710.
IEEE AFYON M,ARTUK C,Yenilmez E,ŞİMŞEK B,KAYA A "Evaluation of Platelet Indices in Young Male Patients with Hepatitis C." , ss.706 - 710, 2016.
ISNAD AFYON, Murat vd. "Evaluation of Platelet Indices in Young Male Patients with Hepatitis C". (2016), 706-710.
APA AFYON M, ARTUK C, Yenilmez E, ŞİMŞEK B, KAYA A (2016). Evaluation of Platelet Indices in Young Male Patients with Hepatitis C. Journal of Clinical and Analytical Medicine, 7(5), 706 - 710.
Chicago AFYON Murat,ARTUK CUMHUR,Yenilmez Ercan,ŞİMŞEK Berksan,KAYA Ayper Evaluation of Platelet Indices in Young Male Patients with Hepatitis C. Journal of Clinical and Analytical Medicine 7, no.5 (2016): 706 - 710.
MLA AFYON Murat,ARTUK CUMHUR,Yenilmez Ercan,ŞİMŞEK Berksan,KAYA Ayper Evaluation of Platelet Indices in Young Male Patients with Hepatitis C. Journal of Clinical and Analytical Medicine, vol.7, no.5, 2016, ss.706 - 710.
AMA AFYON M,ARTUK C,Yenilmez E,ŞİMŞEK B,KAYA A Evaluation of Platelet Indices in Young Male Patients with Hepatitis C. Journal of Clinical and Analytical Medicine. 2016; 7(5): 706 - 710.
Vancouver AFYON M,ARTUK C,Yenilmez E,ŞİMŞEK B,KAYA A Evaluation of Platelet Indices in Young Male Patients with Hepatitis C. Journal of Clinical and Analytical Medicine. 2016; 7(5): 706 - 710.
IEEE AFYON M,ARTUK C,Yenilmez E,ŞİMŞEK B,KAYA A "Evaluation of Platelet Indices in Young Male Patients with Hepatitis C." Journal of Clinical and Analytical Medicine, 7, ss.706 - 710, 2016.
ISNAD AFYON, Murat vd. "Evaluation of Platelet Indices in Young Male Patients with Hepatitis C". Journal of Clinical and Analytical Medicine 7/5 (2016), 706-710.