Efficacy of extracorporeal shockwave therapy and low- intensity pulsed ultrasound in a rat knee osteoarthritis model: A randomized controlled trial
Yıl: 2017 Cilt: 4 Sayı: 2 Sayfa Aralığı: 104 - 108 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022
Efficacy of extracorporeal shockwave therapy and low- intensity pulsed ultrasound in a rat knee osteoarthritis model: A randomized controlled trial
Öz: Objective: This study aims to assess the efficacy of extracorporeal shockwave therapy (ESWT) and low-intensity pulsed ultrasound (LIPUS) on osteoarthritic rat knees.Material and Methods: Twenty-four rats were divided into 3 groups: group 1-control (n=8), group 2-LIPUS (n=8) and group 3-ESWT (n=8). Cartilage degeneration was provided using mono-iodo-asetate (MIA). One milligram of MIA was delivered to the right knees in group 1 and both knees in group 2 and 3. A 0.09% saline solution was delivered to the left knees in group 1 for control. Twenty-four hours after the delivery, ESWT was applied once on the right knees in the group 2 rats to the medial tibia plateu with a 1 Hz frequency and 800 impulses. LIPUS was applied to the right knees in the group 2 rats to the medial tibia plateu with a 3 mHz frequency and 40 mW/cm2 intensity for 20 minutes over a period of 15 days. Pain scores were measured with a knee bend test. Bone mineral density measurements and scintigraphic bone scans were performed. Histopathological examination was done using a modified Mankin scale.Results: There was no difference among the right knee subchondral bone osteoblastic activities (p>0.05). The left knee osteoblastic activities in the LIPUS and extracorporeal shockwave therapy (ESWT) groups were higher than those in the control group (p<0.05), but there was no difference between the LIPUS and ESWT groups. There was no difference among the groups for both knee subchondral bone BMD values (p>0.05). The modified Mankin scores of both the right and left knees of the ESWT and LIPUS groups were lower than those of the control group (p<0.05), but there was no difference between the ESWT and LIPUS groups. The pain scores of both knees of the ESWT and LIPUS groups at day 7 were higher than those of the control group (p<0.05), but there was no difference between the ESWT and LIPUS groups. There was no difference among the pain scores of the right knees at day 14 (p<0.05).Conclusion: ESWT and LIPUS have systemic proliferative and regenerative effects on cartilage and tissue.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Gunal O, karadaş ö, DANDİNOĞLU T, KARACA UMAY E, Cakci A, TAN A (2017). Efficacy of extracorporeal shockwave therapy and low- intensity pulsed ultrasound in a rat knee osteoarthritis model: A randomized controlled trial. , 104 - 108. |
| Chicago | Gunal Ozgur,karadaş ömer,DANDİNOĞLU Taner,KARACA UMAY Ebru,Cakci Aytul,TAN ARİF KENAN Efficacy of extracorporeal shockwave therapy and low- intensity pulsed ultrasound in a rat knee osteoarthritis model: A randomized controlled trial. (2017): 104 - 108. |
| MLA | Gunal Ozgur,karadaş ömer,DANDİNOĞLU Taner,KARACA UMAY Ebru,Cakci Aytul,TAN ARİF KENAN Efficacy of extracorporeal shockwave therapy and low- intensity pulsed ultrasound in a rat knee osteoarthritis model: A randomized controlled trial. , 2017, ss.104 - 108. |
| AMA | Gunal O,karadaş ö,DANDİNOĞLU T,KARACA UMAY E,Cakci A,TAN A Efficacy of extracorporeal shockwave therapy and low- intensity pulsed ultrasound in a rat knee osteoarthritis model: A randomized controlled trial. . 2017; 104 - 108. |
| Vancouver | Gunal O,karadaş ö,DANDİNOĞLU T,KARACA UMAY E,Cakci A,TAN A Efficacy of extracorporeal shockwave therapy and low- intensity pulsed ultrasound in a rat knee osteoarthritis model: A randomized controlled trial. . 2017; 104 - 108. |
| IEEE | Gunal O,karadaş ö,DANDİNOĞLU T,KARACA UMAY E,Cakci A,TAN A "Efficacy of extracorporeal shockwave therapy and low- intensity pulsed ultrasound in a rat knee osteoarthritis model: A randomized controlled trial." , ss.104 - 108, 2017. |
| ISNAD | Gunal, Ozgur vd. "Efficacy of extracorporeal shockwave therapy and low- intensity pulsed ultrasound in a rat knee osteoarthritis model: A randomized controlled trial". (2017), 104-108. |
| APA | Gunal O, karadaş ö, DANDİNOĞLU T, KARACA UMAY E, Cakci A, TAN A (2017). Efficacy of extracorporeal shockwave therapy and low- intensity pulsed ultrasound in a rat knee osteoarthritis model: A randomized controlled trial. European Journal of Rheumatology, 4(2), 104 - 108. |
| Chicago | Gunal Ozgur,karadaş ömer,DANDİNOĞLU Taner,KARACA UMAY Ebru,Cakci Aytul,TAN ARİF KENAN Efficacy of extracorporeal shockwave therapy and low- intensity pulsed ultrasound in a rat knee osteoarthritis model: A randomized controlled trial. European Journal of Rheumatology 4, no.2 (2017): 104 - 108. |
| MLA | Gunal Ozgur,karadaş ömer,DANDİNOĞLU Taner,KARACA UMAY Ebru,Cakci Aytul,TAN ARİF KENAN Efficacy of extracorporeal shockwave therapy and low- intensity pulsed ultrasound in a rat knee osteoarthritis model: A randomized controlled trial. European Journal of Rheumatology, vol.4, no.2, 2017, ss.104 - 108. |
| AMA | Gunal O,karadaş ö,DANDİNOĞLU T,KARACA UMAY E,Cakci A,TAN A Efficacy of extracorporeal shockwave therapy and low- intensity pulsed ultrasound in a rat knee osteoarthritis model: A randomized controlled trial. European Journal of Rheumatology. 2017; 4(2): 104 - 108. |
| Vancouver | Gunal O,karadaş ö,DANDİNOĞLU T,KARACA UMAY E,Cakci A,TAN A Efficacy of extracorporeal shockwave therapy and low- intensity pulsed ultrasound in a rat knee osteoarthritis model: A randomized controlled trial. European Journal of Rheumatology. 2017; 4(2): 104 - 108. |
| IEEE | Gunal O,karadaş ö,DANDİNOĞLU T,KARACA UMAY E,Cakci A,TAN A "Efficacy of extracorporeal shockwave therapy and low- intensity pulsed ultrasound in a rat knee osteoarthritis model: A randomized controlled trial." European Journal of Rheumatology, 4, ss.104 - 108, 2017. |
| ISNAD | Gunal, Ozgur vd. "Efficacy of extracorporeal shockwave therapy and low- intensity pulsed ultrasound in a rat knee osteoarthritis model: A randomized controlled trial". European Journal of Rheumatology 4/2 (2017), 104-108. |
