Yıl: 2016 Cilt: 22 Sayı: 1 Sayfa Aralığı: 28 - 33 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Kronik Hepatit C Hastalarında Serum Hepatit C Virüs RNA Titreleri ile Biyokimyasal Parametreler Arasındaki İlişkinin Değerlendirilmesi

Öz:
Amaç: Karaciğer biyopsisinin yanı sıra noninvaziv bazı biyokimyasal parametreler de kronik hepatit C (KHC) takibinde kullanılmaktadır. Bu çalışmanın amacı, daha önce tedavi edilmemiş kronik HCV hastalarında serum biyokimyasal belirteçler ve HCV RNA titreleri arasındaki ilişkiyi araştırmaktır.Gereç ve Yöntemler: Anti-HCV ve HCV-RNA pozitif 82 KHC hastası retrospektif olarak incelendi. Hastaneye başvurmuş herhangi bir hastalığı olmayan 82 sağlıklı birey kontrol grubu olarak belirlendi. Hasta ve kontrol grubundaki her bir bireyin, tam kan sayımı, total protein (TP), albumin (ALB), C-reaktif protein (CRP), ?-glutamil transpeptidaz (GGT), aspartat aminotransferaz (AST), alanin aminotransferaz (ALT) ve HCV RNA düzeyleri kaydedildi. Nötrofillenfosit oranı (NLR) ve 4 faktöre dayalı fibroz endeksi (FIB-4 endeksi) formüller kullanılarak hesaplandı.Bulgular: KHC hasta ve kontrol grubu arasında ALT, AST, GGT, TP, CRP, kırmızı hücre dağılım genişliği (RDW), lenfositler (LYM), trombositler (PLT), FIB-4 ve NLR değerlerinde anlamlı bir fark vardı (p<0.05). HCV RNA viral yük değerleri ile ALT (r=0,271; p=0,014), TP (r=-0,256; p=0,02), NEU (r=-0,365; p=0,01), WBC (r=-0,362; p=0,001) ve NLR (r=0,282; p=0,01) seviyeleri korelasyon gösterdi.Sonuç: ALT, AST, GGT, TP, CRP, RDW, LYM, FIB-4 and NLR değerlerinin CHC hastalarında arttığını, LYM ve PLT değerlerinin ise azaldığını bulduk. Ayrıca, ALT ve NLR seviyeleri KHC hastalarında HCV RNA titreleri ile korelasyon gösterdi. Bu sonuçlar noninvaziv biyokimyasal parametrelerin kronik hepatit C hastalığının takibine katkı sağlayabileceğini göstermektedir.
Anahtar Kelime:

Konular: Endokrinoloji ve Metabolizma Genel ve Dahili Tıp Hematoloji Gastroenteroloji ve Hepatoloji Biyokimya ve Moleküler Biyoloji Pediatri

The Relationship Between the Serum RNA Titers of Hepatitis C Virus and Biochemical Parameters in Chronic Hepatitis C Patients

Öz:
Objective: Liver biopsy, as well as some non-invasive biochemical parameters are also used in monitoring patients with chronic hepatitis C (CHC). The aim of this study was to investigate the relationship between serum biochemical markers and HCV RNA titers in patients with previously untreated CHC.Materials and Methods: We performed a retrospective study on anti-HCV and HCV-RNA-positive 82 patients with CHC. Eighty two healthy subjects constituted the control group. Complete blood counts, total protein (TP), albumin (ALB), C-reactive protein (CRP), ?-glutamyl transpeptidase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and HCV RNA levels were recorded for each patient and control subject. Neutrophil-lymphocytes ratio (NLR) and the fibrosis index based on the 4 factors (FIB-4 index) were calculated using formulas. Results: There was a significant difference in ALT, AST, GGT, TP, CRP, red cell distribution width (RDW), lymphocytes (LYM), platelets (PLT), FIB-4, and NLR between CHC patients and controls (p=<0.05). Values of HCV RNA viral load were correlated with ALT (r=0.271; p=0.014), TP (r=-0.256; p=0.02), WBC (r=-0.365; p=0.001), NEU (r=-0.362; p=0.001) and NLR (r=0.282; p=0.01) levels.Conclusion: We have shown that ALT, AST, GGT, TP, CRP, RDW, LYM, FIB-4, and NLR values are increased in CHC patients but, LYM and PLT levels were decreased. Also, levels of ALT and NLR have correlated with HCV RNA titers in CHC patients. These results have implied that noninvasive biochemical parameters may contribute to monitoring patients with CHC.
Anahtar Kelime:

Konular: Endokrinoloji ve Metabolizma Genel ve Dahili Tıp Hematoloji Gastroenteroloji ve Hepatoloji Biyokimya ve Moleküler Biyoloji Pediatri
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA nar r, MİLLETLİ SEZGİN F (2016). Kronik Hepatit C Hastalarında Serum Hepatit C Virüs RNA Titreleri ile Biyokimyasal Parametreler Arasındaki İlişkinin Değerlendirilmesi. , 28 - 33.
Chicago nar rukiye,MİLLETLİ SEZGİN FİKRİYE Kronik Hepatit C Hastalarında Serum Hepatit C Virüs RNA Titreleri ile Biyokimyasal Parametreler Arasındaki İlişkinin Değerlendirilmesi. (2016): 28 - 33.
MLA nar rukiye,MİLLETLİ SEZGİN FİKRİYE Kronik Hepatit C Hastalarında Serum Hepatit C Virüs RNA Titreleri ile Biyokimyasal Parametreler Arasındaki İlişkinin Değerlendirilmesi. , 2016, ss.28 - 33.
AMA nar r,MİLLETLİ SEZGİN F Kronik Hepatit C Hastalarında Serum Hepatit C Virüs RNA Titreleri ile Biyokimyasal Parametreler Arasındaki İlişkinin Değerlendirilmesi. . 2016; 28 - 33.
Vancouver nar r,MİLLETLİ SEZGİN F Kronik Hepatit C Hastalarında Serum Hepatit C Virüs RNA Titreleri ile Biyokimyasal Parametreler Arasındaki İlişkinin Değerlendirilmesi. . 2016; 28 - 33.
IEEE nar r,MİLLETLİ SEZGİN F "Kronik Hepatit C Hastalarında Serum Hepatit C Virüs RNA Titreleri ile Biyokimyasal Parametreler Arasındaki İlişkinin Değerlendirilmesi." , ss.28 - 33, 2016.
ISNAD nar, rukiye - MİLLETLİ SEZGİN, FİKRİYE. "Kronik Hepatit C Hastalarında Serum Hepatit C Virüs RNA Titreleri ile Biyokimyasal Parametreler Arasındaki İlişkinin Değerlendirilmesi". (2016), 28-33.
APA nar r, MİLLETLİ SEZGİN F (2016). Kronik Hepatit C Hastalarında Serum Hepatit C Virüs RNA Titreleri ile Biyokimyasal Parametreler Arasındaki İlişkinin Değerlendirilmesi. Viral Hepatitis Journal, 22(1), 28 - 33.
Chicago nar rukiye,MİLLETLİ SEZGİN FİKRİYE Kronik Hepatit C Hastalarında Serum Hepatit C Virüs RNA Titreleri ile Biyokimyasal Parametreler Arasındaki İlişkinin Değerlendirilmesi. Viral Hepatitis Journal 22, no.1 (2016): 28 - 33.
MLA nar rukiye,MİLLETLİ SEZGİN FİKRİYE Kronik Hepatit C Hastalarında Serum Hepatit C Virüs RNA Titreleri ile Biyokimyasal Parametreler Arasındaki İlişkinin Değerlendirilmesi. Viral Hepatitis Journal, vol.22, no.1, 2016, ss.28 - 33.
AMA nar r,MİLLETLİ SEZGİN F Kronik Hepatit C Hastalarında Serum Hepatit C Virüs RNA Titreleri ile Biyokimyasal Parametreler Arasındaki İlişkinin Değerlendirilmesi. Viral Hepatitis Journal. 2016; 22(1): 28 - 33.
Vancouver nar r,MİLLETLİ SEZGİN F Kronik Hepatit C Hastalarında Serum Hepatit C Virüs RNA Titreleri ile Biyokimyasal Parametreler Arasındaki İlişkinin Değerlendirilmesi. Viral Hepatitis Journal. 2016; 22(1): 28 - 33.
IEEE nar r,MİLLETLİ SEZGİN F "Kronik Hepatit C Hastalarında Serum Hepatit C Virüs RNA Titreleri ile Biyokimyasal Parametreler Arasındaki İlişkinin Değerlendirilmesi." Viral Hepatitis Journal, 22, ss.28 - 33, 2016.
ISNAD nar, rukiye - MİLLETLİ SEZGİN, FİKRİYE. "Kronik Hepatit C Hastalarında Serum Hepatit C Virüs RNA Titreleri ile Biyokimyasal Parametreler Arasındaki İlişkinin Değerlendirilmesi". Viral Hepatitis Journal 22/1 (2016), 28-33.