Effects of the Popular Food Additive Sodium Benzoate on Neural Tube Development in the Chicken Embryo

ORAKDÖĞEN, Metin; Somay, Hakan; TURAL EMON, Selin; uslu, serap

Effects of the Popular Food Additive Sodium Benzoate on Neural Tube Development in the Chicken Embryo

Selin TURAL EMON, (Haydarpasa Numune Training and Research Hospital, Department of Neurosurgery, Istanbul, Turkey)

Metin ORAKDÖĞEN, (Haydarpasa Numune Training and Research Hospital, Department of Neurosurgery, Istanbul, Turkey)

Serap USLU, (Acibadem University, Vocational School of Health Services, Department of Histology and Embryology, Istanbul, Turkey)

Hakan SOMAY (Haydarpasa Numune Training and Research Hospital, Department of Neurosurgery, Istanbul, Turkey)

Turkish Neurosurgery

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Yıl: 2015 Cilt: 25 Sayı: 2 Sayfa Aralığı: 294 - 297 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Effects of the Popular Food Additive Sodium Benzoate on Neural Tube Development in the Chicken Embryo

Öz:

AmAÇ: İşlenmiş gıdaların gelişimi ile birlikte hayatımıza daha fazla katkı maddesi girmiştir. Nöral tüp defektleri santral sinir sisteminin konjenital malformasyonlarıdır. Her yıl, 300 000'den fazla çocuk nöral tüp defekti ile doğar, yaşayanlar ise engelli olarak hayatlarına devam ederler. Sodyum benzoat günlük hayatımızda yoğun olarak kullanılmaktadır. Biz de bu verilerin bir sonucu olarak tavuk embriyolarında nöral tüp defekti gelişimi üzerine sodyum benzoatın etkilerini değerlendirmeyi amaçladık. yÖNTEm ve GEREÇlER: Döllenmiş, spesifik patojensiz yumurtalar kullanıldı. Çalışma beş grupdan oluşuyordu. Enkübasyondan 30 saat sonra yumurtalar 4x optik büyütme altında açıldı. Embriyonik disk tespit edildi ve sodyum benzoat solüsyonu enjekte edildi. Yumurta steril bantlar ile kapatıldı ve 72. saate kadar beklenildi. Sonra, bütün yumurtalar tekrar açıldı ve embriyolar embriyonik membrandan disseke edilerek çıkartıldı ve histopatolojik olarak incelendi. BulGulAR: Bütün embriyoların gelişimleri bulundukları evre ile uyumlu bulundu. Yalnızca bir embriyoda nöral tüp tıkanıklığı tespit edildi. Embriyolarda nöral tüp defekti tespit edilmedi. soNuÇ: Çalışma, yaygın olarak kullanan gıda koruyucularından biri olan sodyum benzoatın civciv embriyosunda yüksek dozda bile nöral tüp defekti gelişimi üzerine etkisi olmadığını göstermiştir

Anahtar Kelime:

Konular: Biyoloji

Yaygın Olarak Kullanılan Gıda Katkı Maddelerinden Sodyum Benzoatın Tavuk Embriyosunda Nöral Tüp Gelişimi Üzerine Etkileri

Öz:

AIm: Many more additives have been introduced with the development of processed foods. Neural tube defects are congenital malformations of the central nervous system. More than 300 000 children are born with neural tube defects every year and surviving children remain disabled for life. Sodium benzoate is used intensively in our daily lives. We therefore aimed to evaluate the effects of sodium benzoate on neural tube defects in chicken embryos. mATERIAl and mEThods: Fertile, specific pathogen-free eggs were used. The study was conducted on five groups. After 30 hours of incubation, the eggs were opened under 4x optical magnification. The embryonic disc was identified and sodium benzoate solution was injected. Eggs were closed with sterile adhesive strips and incubation was continued till the end of the 72nd hour. All eggs were then reopened and embryos were dissected from embryonic membranes and evaluated histopathologically. REsulTs: We found that the development of all embryos was consistent with the stage. We detected neural tube obstruction in one embryo. Neural tube defects were not detected in any embryos. CoNClusIoN: This study showed that sodium benzoate as one of the widely used food preservatives has no effect to neural tube defect development in chicken embryos even at high doses

Anahtar Kelime:

Konular: Biyoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	TURAL EMON S, ORAKDÖĞEN M, uslu s, Somay H (2015). Effects of the Popular Food Additive Sodium Benzoate on Neural Tube Development in the Chicken Embryo. , 294 - 297.
Chicago	TURAL EMON Selin,ORAKDÖĞEN Metin,uslu serap,Somay Hakan Effects of the Popular Food Additive Sodium Benzoate on Neural Tube Development in the Chicken Embryo. (2015): 294 - 297.
MLA	TURAL EMON Selin,ORAKDÖĞEN Metin,uslu serap,Somay Hakan Effects of the Popular Food Additive Sodium Benzoate on Neural Tube Development in the Chicken Embryo. , 2015, ss.294 - 297.
AMA	TURAL EMON S,ORAKDÖĞEN M,uslu s,Somay H Effects of the Popular Food Additive Sodium Benzoate on Neural Tube Development in the Chicken Embryo. . 2015; 294 - 297.
Vancouver	TURAL EMON S,ORAKDÖĞEN M,uslu s,Somay H Effects of the Popular Food Additive Sodium Benzoate on Neural Tube Development in the Chicken Embryo. . 2015; 294 - 297.
IEEE	TURAL EMON S,ORAKDÖĞEN M,uslu s,Somay H "Effects of the Popular Food Additive Sodium Benzoate on Neural Tube Development in the Chicken Embryo." , ss.294 - 297, 2015.
ISNAD	TURAL EMON, Selin vd. "Effects of the Popular Food Additive Sodium Benzoate on Neural Tube Development in the Chicken Embryo". (2015), 294-297.

APA	TURAL EMON S, ORAKDÖĞEN M, uslu s, Somay H (2015). Effects of the Popular Food Additive Sodium Benzoate on Neural Tube Development in the Chicken Embryo. Turkish Neurosurgery, 25(2), 294 - 297.
Chicago	TURAL EMON Selin,ORAKDÖĞEN Metin,uslu serap,Somay Hakan Effects of the Popular Food Additive Sodium Benzoate on Neural Tube Development in the Chicken Embryo. Turkish Neurosurgery 25, no.2 (2015): 294 - 297.
MLA	TURAL EMON Selin,ORAKDÖĞEN Metin,uslu serap,Somay Hakan Effects of the Popular Food Additive Sodium Benzoate on Neural Tube Development in the Chicken Embryo. Turkish Neurosurgery, vol.25, no.2, 2015, ss.294 - 297.
AMA	TURAL EMON S,ORAKDÖĞEN M,uslu s,Somay H Effects of the Popular Food Additive Sodium Benzoate on Neural Tube Development in the Chicken Embryo. Turkish Neurosurgery. 2015; 25(2): 294 - 297.
Vancouver	TURAL EMON S,ORAKDÖĞEN M,uslu s,Somay H Effects of the Popular Food Additive Sodium Benzoate on Neural Tube Development in the Chicken Embryo. Turkish Neurosurgery. 2015; 25(2): 294 - 297.
IEEE	TURAL EMON S,ORAKDÖĞEN M,uslu s,Somay H "Effects of the Popular Food Additive Sodium Benzoate on Neural Tube Development in the Chicken Embryo." Turkish Neurosurgery, 25, ss.294 - 297, 2015.
ISNAD	TURAL EMON, Selin vd. "Effects of the Popular Food Additive Sodium Benzoate on Neural Tube Development in the Chicken Embryo". Turkish Neurosurgery 25/2 (2015), 294-297.