Yıl: 2015 Cilt: 57 Sayı: 3 Sayfa Aralığı: 242 - 247 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Platelets and platelet-derived growth factor in closure of the ductus arteriosus

Öz:
Engür D, Kaynak-Türkmen M, Deveci M, Yenisey Ç. Platelets and platelet-derived growth factor in closure of the ductus arteriosus. Turk J Pediatr 2015; 57: 242-247.The crucial role of platelets in the permanent closure of the ductus arteriosus has recently been elucidated in an animal model; however, clinical studies investigating the impact of platelet count on ductal patency have conflicting results. Our aim is to compare platelet count, indices and serum platelet-derived growth factor levels in preterms with and without ductal patency. Preterms with a gestational age of 27-30 weeks followed up during a twelve-month period in the neonatal intensive care unit of Adnan Menderes University Hospital were enrolled. Infants underwent echocardiographic evaluation starting on the second day and subsequently assessed every other day until ductal closure was achieved, or upon clinical signs of reopening. Platelet-derived growth factor was measured on the second and fifth days of life. Eleven very low birth weight infants who subsequently required medical treatment for patent ductus arteriosus were compared with twenty-three infants with closed ductus. Although platelet count and indices were similar, median serum plateletderived growth factor levels on day 5 were significantly lower among babies who subsequently required medical treatment for ductal patency (874.6 vs 1099.6 pg/ml). The current study points out a possible association between serum platelet-derived growth factor levels and ductal closure. Our results suggest that platelet-derived growth factor may play a role in ductal closure independent from platelet count and might be used as an adjunct surrogate for prediction of future need for treatment for hemodynamically significant patent ductus arteriosus in preterm infants.
Anahtar Kelime:

Konular: Pediatri
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Hamrick SE, Hansmann G. Patent ductus arteriosus of the preterm infant. Pediatrics 2010; 125: 1020-1030.
  • 2. Echtler K, Stark K, Lorenz M, et al. Platelets contribute to postnatal occlusion of the ductus arteriosus. Nat Med 2010; 16: 75-82.
  • 3. Clyman R, Chemtob S. Vessel remodeling in the newborn: platelets fill the gap. Nat Med 2010; 16: 33-35.
  • 4. Shah NA, Hills NK, Waleh N, et al. Relationship between circulating platelet counts and ductus arteriosus patency after indomethacin treatment. J Pediatr 2011; 158: 919-923.
  • 5. Alyamac Dizdar E, Ozdemir R, Sari FN, et al. Low platelet count is associated with ductus arteriosus patency in preterm newborns. Early Hum Dev 2012; 88: 813-816.
  • 6. Sallmon H, Weber SC, Hüning B, et al. Thrombocytopenia in the first 24 hours after birth and incidence of patent ductus arteriosus. Pediatrics 2012; 130: e623-e630.
  • 7. Fujioka K, Morioka I, Miwa A, et al. Does thrombocytopenia contribute to patent ductus arteriosus? Nat Med 2011; 17: 29-30.
  • 8. Dani C, Poggi C, Fontanelli G. Relationship between platelet count and volume and spontaneous and pharmacological closure of ductus arteriosus in preterm infants. Am J Perinatol 2013; 30: 359-364.
  • 9. Antoniades HN. PDGF: A multifunctional growth factor. Baillieres Clin Endocrinol Metab 1991; 5: 595-613.
  • 10. Bowen-Pope DF, Raines EW. History of discovery: platelet-derived growth factor. Arterioscler Thromb Vasc Biol 2011; 31: 2397-2401.
  • 11. Hoch RV, Soriano P. Roles of PDGF in animal development. Development 2003; 130: 4769-4784.
  • 12. Heldin CH, Ostman A, Rönnstrand L. Signal transduction via platelet-derived growth factor receptors. Biochim Biophys Acta 1998; 1378: F79-F113.
  • 13. Baumgartner HR, Hosang M. Platelets, platelet-derived growth factor and arteriosclerosis. Experientia 1988; 44: 109-112.
  • 14. Li C, Li J, Li Y, et al. Crosstalk between platelets and the immune system: old systems with new discoveries. Adv Hematol 2012; 2012: 384685.
  • 15. Coceani F, Baragatti B. Mechanisms for ductus arteriosus closure. Semin Perinatol 2012; 36: 92-97.
  • 16. Bökenkamp R, DeRuiter MC, van Munsteren C, Gittenberger-de Groot AC. Insights into the pathogenesis and genetic background of patency of the ductus arteriosus. Neonatology 2010; 98: 6-17.
  • 17. Clyman RI. Mechanisms regulating the ductus arteriosus. Biol Neonate 2006; 89: 330-335.
  • 18. Engür MA, Engür D. Platelet-rich plasma for pa tent ductus arteriosus: an orthopaedic surgeon's perspective. Cardiol Young 2014; 24: 385-387.
  • 19. Lin F, Zhu J, Tonnesen MG, et al. Fibronectin peptides that bind PDGF-BB enhance survival of cells and tissue under stress. J Invest Dermatol 2014; 134: 1119-1127.
  • 20. Weber SC, Gratopp A, Akanbi S, et al. Isolation and culture of fibroblasts, vascular smooth muscle, and endothelial cells from the fetal rat ductus arteriosus. Pediatr Res 2011; 70: 236-241.
  • 21. Seppä H, Grotendorst G, Seppä S, Schiffmann E, Martin GR. Platelet-derived growth factor in chemotactic for fibroblasts. J Cell Biol 1982; 92: 584-588.
  • 22. Heldin P, Asplund T, Ytterberg D, Thelin S, Laurent TC. Characterization of the molecular mechanism involved in the activation of hyaluronan synthetase by platelet-derived growth factor in human mesothelial cells. Biochem J 1992; 283: 165-170.
  • 23. McNamara PJ, Sehgal A. Towards rational management of the patent ductus arteriosus: the need for disease staging. Arch Dis Child Fetal Neonatal Ed 2007; 92: F424-F427.
APA ENGÜR D, KAYNAK TÜRKMEN M, DEVECİ M, Yenisey Ç (2015). Platelets and platelet-derived growth factor in closure of the ductus arteriosus. , 242 - 247.
Chicago ENGÜR Defne,KAYNAK TÜRKMEN MÜNEVVER,DEVECİ MURAT,Yenisey Çiğdem Platelets and platelet-derived growth factor in closure of the ductus arteriosus. (2015): 242 - 247.
MLA ENGÜR Defne,KAYNAK TÜRKMEN MÜNEVVER,DEVECİ MURAT,Yenisey Çiğdem Platelets and platelet-derived growth factor in closure of the ductus arteriosus. , 2015, ss.242 - 247.
AMA ENGÜR D,KAYNAK TÜRKMEN M,DEVECİ M,Yenisey Ç Platelets and platelet-derived growth factor in closure of the ductus arteriosus. . 2015; 242 - 247.
Vancouver ENGÜR D,KAYNAK TÜRKMEN M,DEVECİ M,Yenisey Ç Platelets and platelet-derived growth factor in closure of the ductus arteriosus. . 2015; 242 - 247.
IEEE ENGÜR D,KAYNAK TÜRKMEN M,DEVECİ M,Yenisey Ç "Platelets and platelet-derived growth factor in closure of the ductus arteriosus." , ss.242 - 247, 2015.
ISNAD ENGÜR, Defne vd. "Platelets and platelet-derived growth factor in closure of the ductus arteriosus". (2015), 242-247.
APA ENGÜR D, KAYNAK TÜRKMEN M, DEVECİ M, Yenisey Ç (2015). Platelets and platelet-derived growth factor in closure of the ductus arteriosus. Turkish Journal of Pediatrics, 57(3), 242 - 247.
Chicago ENGÜR Defne,KAYNAK TÜRKMEN MÜNEVVER,DEVECİ MURAT,Yenisey Çiğdem Platelets and platelet-derived growth factor in closure of the ductus arteriosus. Turkish Journal of Pediatrics 57, no.3 (2015): 242 - 247.
MLA ENGÜR Defne,KAYNAK TÜRKMEN MÜNEVVER,DEVECİ MURAT,Yenisey Çiğdem Platelets and platelet-derived growth factor in closure of the ductus arteriosus. Turkish Journal of Pediatrics, vol.57, no.3, 2015, ss.242 - 247.
AMA ENGÜR D,KAYNAK TÜRKMEN M,DEVECİ M,Yenisey Ç Platelets and platelet-derived growth factor in closure of the ductus arteriosus. Turkish Journal of Pediatrics. 2015; 57(3): 242 - 247.
Vancouver ENGÜR D,KAYNAK TÜRKMEN M,DEVECİ M,Yenisey Ç Platelets and platelet-derived growth factor in closure of the ductus arteriosus. Turkish Journal of Pediatrics. 2015; 57(3): 242 - 247.
IEEE ENGÜR D,KAYNAK TÜRKMEN M,DEVECİ M,Yenisey Ç "Platelets and platelet-derived growth factor in closure of the ductus arteriosus." Turkish Journal of Pediatrics, 57, ss.242 - 247, 2015.
ISNAD ENGÜR, Defne vd. "Platelets and platelet-derived growth factor in closure of the ductus arteriosus". Turkish Journal of Pediatrics 57/3 (2015), 242-247.