Nerve Tissue Prefabrication Inside the Rat Femoral Bone: Does It Work?

ÖZKARA, Emre; ARSLANTAŞ, Ali; SÖZTUTAR, ERDEM; KOÇMAN, Atacan Emre; ÖZBEK, Zühtü; KOSE, AYDAN AYSE; ÖZATİK, ORHAN; çetin, cengiz

Nerve Tissue Prefabrication Inside the Rat Femoral Bone: Does It Work?

Zühtü ÖZBEK, (Eskisehir Osmangazi University, Medical Faculty, Department of Neurosurgery, Eskisehir, Turkey)

Atacan Emre KOÇMAN, (Eskisehir Osmangazi University, Medical Faculty, Department of Plastic Surgery, Eskisehir, Turkey)

ORHAN ÖZATİK, (Ahi Evran University, Medical Faculty, Department of Histology and Embryology, Kırsehir, Turkey)

ERDEM SÖZTUTAR, (Eskisehir Osmangazi University, Medical Faculty, Department of Anatomy, Eskisehir, Turkey)

Emre ÖZKARA, (Eskisehir Osmangazi University, Medical Faculty, Department of Neurosurgery, Eskisehir, Turkey)

AYDAN AYŞE KÖSE, (Eskisehir Osmangazi University, Medical Faculty, Department of Plastic Surgery, Eskisehir, Turkey)

Ali ARSLANTAŞ, (Eskisehir Osmangazi University, Medical Faculty, Department of Neurosurgery, Eskisehir, Turkey)

Cengiz ÇETİN (Eskisehir Osmangazi University, Medical Faculty, Department of Plastic Surgery, Eskisehir, Turkey)

Turkish Neurosurgery

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Yıl: 2017 Cilt: 27 Sayı: 4 Sayfa Aralığı: 648 - 655 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Nerve Tissue Prefabrication Inside the Rat Femoral Bone: Does It Work?

Öz:

AIm: To investigate whether nerve regeneration can be induced in the tubular bone between distal and proximal cut nerve ends. mATERIAl and mEThODS: Twenty adult Wistar rats were used for the study. Rats were divided into three groups; femoral bone conduit group, nerve transection group, sham group. The sciatic nerve was surgically cut and from both ends inserted into the adjacent femoral bone tunnel in the femoral bone conduit group. The sciatic nerve was cut transversely in the nerve transection group. In the Sham group, only sciatic nerve exploration was performed, without a nerve cut. The groups were evaluated functionally and morphologically. RESUlTS: All results showed that axonal growth existed through the osseous canal. CONClUSION: To the best of our knowledge, this is the first study to evaluate neural regeneration inside the bone. We can speculate that the bone marrow provides a convenient microenvironment for peripheral nerve regeneration. In addition to prefabricating peripheral nerves, this novel model may help to establish further strategies for engineering of other tissues in the bone marrow

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÖZBEK Z, KOÇMAN A, ÖZATİK O, SÖZTUTAR E, ÖZKARA E, KOSE A, ARSLANTAŞ A, çetin c (2017). Nerve Tissue Prefabrication Inside the Rat Femoral Bone: Does It Work?. , 648 - 655.
Chicago	ÖZBEK Zühtü,KOÇMAN Atacan Emre,ÖZATİK ORHAN,SÖZTUTAR ERDEM,ÖZKARA Emre,KOSE AYDAN AYSE,ARSLANTAŞ Ali,çetin cengiz Nerve Tissue Prefabrication Inside the Rat Femoral Bone: Does It Work?. (2017): 648 - 655.
MLA	ÖZBEK Zühtü,KOÇMAN Atacan Emre,ÖZATİK ORHAN,SÖZTUTAR ERDEM,ÖZKARA Emre,KOSE AYDAN AYSE,ARSLANTAŞ Ali,çetin cengiz Nerve Tissue Prefabrication Inside the Rat Femoral Bone: Does It Work?. , 2017, ss.648 - 655.
AMA	ÖZBEK Z,KOÇMAN A,ÖZATİK O,SÖZTUTAR E,ÖZKARA E,KOSE A,ARSLANTAŞ A,çetin c Nerve Tissue Prefabrication Inside the Rat Femoral Bone: Does It Work?. . 2017; 648 - 655.
Vancouver	ÖZBEK Z,KOÇMAN A,ÖZATİK O,SÖZTUTAR E,ÖZKARA E,KOSE A,ARSLANTAŞ A,çetin c Nerve Tissue Prefabrication Inside the Rat Femoral Bone: Does It Work?. . 2017; 648 - 655.
IEEE	ÖZBEK Z,KOÇMAN A,ÖZATİK O,SÖZTUTAR E,ÖZKARA E,KOSE A,ARSLANTAŞ A,çetin c "Nerve Tissue Prefabrication Inside the Rat Femoral Bone: Does It Work?." , ss.648 - 655, 2017.
ISNAD	ÖZBEK, Zühtü vd. "Nerve Tissue Prefabrication Inside the Rat Femoral Bone: Does It Work?". (2017), 648-655.

APA	ÖZBEK Z, KOÇMAN A, ÖZATİK O, SÖZTUTAR E, ÖZKARA E, KOSE A, ARSLANTAŞ A, çetin c (2017). Nerve Tissue Prefabrication Inside the Rat Femoral Bone: Does It Work?. Turkish Neurosurgery, 27(4), 648 - 655.
Chicago	ÖZBEK Zühtü,KOÇMAN Atacan Emre,ÖZATİK ORHAN,SÖZTUTAR ERDEM,ÖZKARA Emre,KOSE AYDAN AYSE,ARSLANTAŞ Ali,çetin cengiz Nerve Tissue Prefabrication Inside the Rat Femoral Bone: Does It Work?. Turkish Neurosurgery 27, no.4 (2017): 648 - 655.
MLA	ÖZBEK Zühtü,KOÇMAN Atacan Emre,ÖZATİK ORHAN,SÖZTUTAR ERDEM,ÖZKARA Emre,KOSE AYDAN AYSE,ARSLANTAŞ Ali,çetin cengiz Nerve Tissue Prefabrication Inside the Rat Femoral Bone: Does It Work?. Turkish Neurosurgery, vol.27, no.4, 2017, ss.648 - 655.
AMA	ÖZBEK Z,KOÇMAN A,ÖZATİK O,SÖZTUTAR E,ÖZKARA E,KOSE A,ARSLANTAŞ A,çetin c Nerve Tissue Prefabrication Inside the Rat Femoral Bone: Does It Work?. Turkish Neurosurgery. 2017; 27(4): 648 - 655.
Vancouver	ÖZBEK Z,KOÇMAN A,ÖZATİK O,SÖZTUTAR E,ÖZKARA E,KOSE A,ARSLANTAŞ A,çetin c Nerve Tissue Prefabrication Inside the Rat Femoral Bone: Does It Work?. Turkish Neurosurgery. 2017; 27(4): 648 - 655.
IEEE	ÖZBEK Z,KOÇMAN A,ÖZATİK O,SÖZTUTAR E,ÖZKARA E,KOSE A,ARSLANTAŞ A,çetin c "Nerve Tissue Prefabrication Inside the Rat Femoral Bone: Does It Work?." Turkish Neurosurgery, 27, ss.648 - 655, 2017.
ISNAD	ÖZBEK, Zühtü vd. "Nerve Tissue Prefabrication Inside the Rat Femoral Bone: Does It Work?". Turkish Neurosurgery 27/4 (2017), 648-655.