Polikistik over sendromlu kadınlarda lenfositler ve servikal hücrelerde mikronükleus frekansları

gezginç, kazım; Zamani, Ayse Gul; tuncez, ebru; KARANFİL, Fikriye; Acar, Aynur; YILDIRIM, M. Selman; SOYSAL, Sema; KARATAYLI, Rengin

Polikistik over sendromlu kadınlarda lenfositler ve servikal hücrelerde mikronükleus frekansları

Rengin KARATAYLI, (Konya Private Selçuklu Hospital, Clinic of Obstetrics and Gynecology, Konya, Turkey)

Ayşe Gül ZAMANİ, (Necmettin Erbakan University Meram Faculty of Medicine, Department of Medical Genetics, Konya, Turkey)

Kazım GEZGİNÇ, (Necmettin Erbakan University Meram Faculty of Medicine, Department of Obstetrics and Gynecology, Konya, Turkey)

Ebru TUNCEZ, (Şanlıurfa Pediatric Disease Hospital, Clinic of Medical Genetics, Şanlıurfa, Turkey)

Sema SOYSAL, (Necmettin Erbakan University Meram Faculty of Medicine, Department of Medical Education and Informatics, Konya, Turkey)

Fikriye KARANFİL, (University of Health Sciences, Konya Training and Research Hospital, Clinic of Obstetrics and Gynecology, Konya, Turkey)

Aynur ACAR, (İstanbul Bilim University Faculty of Science, Department of Molecular Biology and Genetics, İstanbul, Turkey)

M. Selman YILDIRIM (Necmettin Erbakan University Meram Faculty of Medicine, Department of Medical Genetics, Konya, Turkey)

Turkish Journal of Obstetrics and Gynecology

4 1

Yıl: 2017 Cilt: 14 Sayı: 3 Sayfa Aralığı: 151 - 155 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Polikistik over sendromlu kadınlarda lenfositler ve servikal hücrelerde mikronükleus frekansları

Öz:

Amaç: Bu çalışmanın amacı, polikistik over sendromlu (PKOS) kadınların eksfoliyatif servikal hücrelerinde ve periferik kan lenfositlerinde mikronükleus (MN) frekanslarını belirlemektir.Gereç ve Yöntemler: PKOS'li 15 hasta ve 11 sağlıklı kontrol hastası çalışmaya dahil edildi. Tüm hastalardan servikal smearleri ve periferik kan toplandı. Numuneler, MN frekansları açısından analiz edildi ve gruplar arasında karşılaştırıldı. Hem MN sıklığı, hem de genotoksisite ve sitotoksite bağlı diğer nükleer anomaliler değerlendirildi. Bulgular: Servikal smear ve periferik kan lenfositlerinde MN frekansları PKOS hastaları ve normal kontrollerde karşılaştırıldı. Periferik kan lenfositlerinde MN frekansı açısından gruplar arasında istatistiksel olarak anlamlı fark yoktu (p=0,239). PKOS hastalarının eksfoliyatif servikal hücrelerindeki ortalama MN skorları ve normal kontrollerinki sırasıyla 1,19±0,57 ve 0,74±0,34 idi. Servikal hücrelerdeki MN frekansları istatistiksel olarak gruplar arasında anlamlıydı (p=0,032). Sonuç: Çalışma grubu küçük olmasına rağmen çalışma sonuçlarımız, PKOS hastalarının eksfoliyatif hücrelerinde, hastalıkta genetik tehlikenin belirleyicisi olan MN sıklığının arttığını desteklemektedir.

Anahtar Kelime:

Konular: Cerrahi

Micronuclei frequencies in lymphocytes and cervical cells of women with polycystic ovarian syndrome

Öz:

Objective: The aim of this study was to determine micronucleus (MN) frequencies in exfoliated cervical cells and peripheral blood lymphocytes of women with polycystic ovarian syndrome (PCOS).Materials and Methods: Fifteen patients with PCOS and 11 healthy control patients were included in the study. Cervical smears and peripheral blood were collected from all patients. Specimens were analyzed for MN frequencies and compared between the groups. In addition to MN, other nuclear anomalies connected with both genotoxicity and cytotoxicity were evaluated.Results: The MN frequencies in cervical smear and peripheral blood lymphocytes were compared in patients with PCOS and normal controls. There was no statistically significant difference between the groups regarding micronucleus frequency in peripheral blood lymphocytes (p=0.239). The mean MN scores in exfoliated cervical cells of patients with PCOS and normal controls were 1.19±0.57 and 0.74±0.34, respectively. The difference regarding micronucleus frequencies in cervical cells was statistically significant between the groups (p=0.032).Conclusion: Although study group is small, our study results support that there is an increased micronucleus frequency in cervical exfoliated cells of PCOS patients; this is a determinant of genetic hazard in the disease.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KARATAYLI R, Zamani A, gezginç k, tuncez e, SOYSAL S, KARANFİL F, Acar A, YILDIRIM M (2017). Polikistik over sendromlu kadınlarda lenfositler ve servikal hücrelerde mikronükleus frekansları. , 151 - 155.
Chicago	KARATAYLI Rengin,Zamani Ayse Gul,gezginç kazım,tuncez ebru,SOYSAL Sema,KARANFİL Fikriye,Acar Aynur,YILDIRIM M. Selman Polikistik over sendromlu kadınlarda lenfositler ve servikal hücrelerde mikronükleus frekansları. (2017): 151 - 155.
MLA	KARATAYLI Rengin,Zamani Ayse Gul,gezginç kazım,tuncez ebru,SOYSAL Sema,KARANFİL Fikriye,Acar Aynur,YILDIRIM M. Selman Polikistik over sendromlu kadınlarda lenfositler ve servikal hücrelerde mikronükleus frekansları. , 2017, ss.151 - 155.
AMA	KARATAYLI R,Zamani A,gezginç k,tuncez e,SOYSAL S,KARANFİL F,Acar A,YILDIRIM M Polikistik over sendromlu kadınlarda lenfositler ve servikal hücrelerde mikronükleus frekansları. . 2017; 151 - 155.
Vancouver	KARATAYLI R,Zamani A,gezginç k,tuncez e,SOYSAL S,KARANFİL F,Acar A,YILDIRIM M Polikistik over sendromlu kadınlarda lenfositler ve servikal hücrelerde mikronükleus frekansları. . 2017; 151 - 155.
IEEE	KARATAYLI R,Zamani A,gezginç k,tuncez e,SOYSAL S,KARANFİL F,Acar A,YILDIRIM M "Polikistik over sendromlu kadınlarda lenfositler ve servikal hücrelerde mikronükleus frekansları." , ss.151 - 155, 2017.
ISNAD	KARATAYLI, Rengin vd. "Polikistik over sendromlu kadınlarda lenfositler ve servikal hücrelerde mikronükleus frekansları". (2017), 151-155.

APA	KARATAYLI R, Zamani A, gezginç k, tuncez e, SOYSAL S, KARANFİL F, Acar A, YILDIRIM M (2017). Polikistik over sendromlu kadınlarda lenfositler ve servikal hücrelerde mikronükleus frekansları. Turkish Journal of Obstetrics and Gynecology, 14(3), 151 - 155.
Chicago	KARATAYLI Rengin,Zamani Ayse Gul,gezginç kazım,tuncez ebru,SOYSAL Sema,KARANFİL Fikriye,Acar Aynur,YILDIRIM M. Selman Polikistik over sendromlu kadınlarda lenfositler ve servikal hücrelerde mikronükleus frekansları. Turkish Journal of Obstetrics and Gynecology 14, no.3 (2017): 151 - 155.
MLA	KARATAYLI Rengin,Zamani Ayse Gul,gezginç kazım,tuncez ebru,SOYSAL Sema,KARANFİL Fikriye,Acar Aynur,YILDIRIM M. Selman Polikistik over sendromlu kadınlarda lenfositler ve servikal hücrelerde mikronükleus frekansları. Turkish Journal of Obstetrics and Gynecology, vol.14, no.3, 2017, ss.151 - 155.
AMA	KARATAYLI R,Zamani A,gezginç k,tuncez e,SOYSAL S,KARANFİL F,Acar A,YILDIRIM M Polikistik over sendromlu kadınlarda lenfositler ve servikal hücrelerde mikronükleus frekansları. Turkish Journal of Obstetrics and Gynecology. 2017; 14(3): 151 - 155.
Vancouver	KARATAYLI R,Zamani A,gezginç k,tuncez e,SOYSAL S,KARANFİL F,Acar A,YILDIRIM M Polikistik over sendromlu kadınlarda lenfositler ve servikal hücrelerde mikronükleus frekansları. Turkish Journal of Obstetrics and Gynecology. 2017; 14(3): 151 - 155.
IEEE	KARATAYLI R,Zamani A,gezginç k,tuncez e,SOYSAL S,KARANFİL F,Acar A,YILDIRIM M "Polikistik over sendromlu kadınlarda lenfositler ve servikal hücrelerde mikronükleus frekansları." Turkish Journal of Obstetrics and Gynecology, 14, ss.151 - 155, 2017.
ISNAD	KARATAYLI, Rengin vd. "Polikistik over sendromlu kadınlarda lenfositler ve servikal hücrelerde mikronükleus frekansları". Turkish Journal of Obstetrics and Gynecology 14/3 (2017), 151-155.