The effect of proanthocyanidin on formaldehyde-induced toxicity in rat testes

Enis ULUÇAM, (Trakya Üniversitesi Tıp Fakültesi Anatomi Anabilim Dalı, Edirne, Türkiye)
Elvan BAKAR (Trakya Üniversitesi Eczacılık Fakültesi Farmasötik Teknoloji Anabilim Dalı, Edirne, Türkiye)
Turkish Journal of Medical Sciences
8 0
Yıl: 2016 Cilt: 46 Sayı: 1 Sayfa Aralığı: 185 - 193 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

The effect of proanthocyanidin on formaldehyde-induced toxicity in rat testes

Öz:
Background/aim: This study investigated the effect of proanthocyanidin (PA) against formaldehyde (FA)-induced lipid peroxidation damage and morphological changes in rat testes. Materials and methods: Twenty-one Wistar albino rats were randomized into 3 groups: control, FA, and FA + PA groups. Plasma and tissue malondialdehyde (MDA) and total sialic acid (TSA) levels were measured. Testes tissues were observed by light and electron microscopy. Results: TSA (plasma and tissue) levels decreased and MDA (plasma) significantly increased (P < 0.05) in rats treated with FA compared to the controls. Tissue MDA levels were not significantly different. Several necrotic changes were observed in testes tissues by light and electron microscopy. Disordering in epithelia of seminiferous tubules, vacuolization between germinal epithelium cells, and separated basement membranes were observed by light microscope. Immunopositivity in Leydig cells decreased in the FA group (P < 0.05). In the FA + PA group there were more immune Leydig cells reacting immune-positively than in the FA group (P < 0.05). Ultrastructurally, FA also caused disorganization and loss of mitochondrial cristae, and dilatation in endoplasmic reticulum in testes. Conclusion: The results suggest that PA has a protective effect on FA toxicity in testes.
Anahtar Kelime:

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA ULUÇAM E, BAKAR E (2016). The effect of proanthocyanidin on formaldehyde-induced toxicity in rat testes. , 185 - 193.
Chicago ULUÇAM Enis,BAKAR Elvan The effect of proanthocyanidin on formaldehyde-induced toxicity in rat testes. (2016): 185 - 193.
MLA ULUÇAM Enis,BAKAR Elvan The effect of proanthocyanidin on formaldehyde-induced toxicity in rat testes. , 2016, ss.185 - 193.
AMA ULUÇAM E,BAKAR E The effect of proanthocyanidin on formaldehyde-induced toxicity in rat testes. . 2016; 185 - 193.
Vancouver ULUÇAM E,BAKAR E The effect of proanthocyanidin on formaldehyde-induced toxicity in rat testes. . 2016; 185 - 193.
IEEE ULUÇAM E,BAKAR E "The effect of proanthocyanidin on formaldehyde-induced toxicity in rat testes." , ss.185 - 193, 2016.
ISNAD ULUÇAM, Enis - BAKAR, Elvan. "The effect of proanthocyanidin on formaldehyde-induced toxicity in rat testes". (2016), 185-193.
APA ULUÇAM E, BAKAR E (2016). The effect of proanthocyanidin on formaldehyde-induced toxicity in rat testes. Turkish Journal of Medical Sciences, 46(1), 185 - 193.
Chicago ULUÇAM Enis,BAKAR Elvan The effect of proanthocyanidin on formaldehyde-induced toxicity in rat testes. Turkish Journal of Medical Sciences 46, no.1 (2016): 185 - 193.
MLA ULUÇAM Enis,BAKAR Elvan The effect of proanthocyanidin on formaldehyde-induced toxicity in rat testes. Turkish Journal of Medical Sciences, vol.46, no.1, 2016, ss.185 - 193.
AMA ULUÇAM E,BAKAR E The effect of proanthocyanidin on formaldehyde-induced toxicity in rat testes. Turkish Journal of Medical Sciences. 2016; 46(1): 185 - 193.
Vancouver ULUÇAM E,BAKAR E The effect of proanthocyanidin on formaldehyde-induced toxicity in rat testes. Turkish Journal of Medical Sciences. 2016; 46(1): 185 - 193.
IEEE ULUÇAM E,BAKAR E "The effect of proanthocyanidin on formaldehyde-induced toxicity in rat testes." Turkish Journal of Medical Sciences, 46, ss.185 - 193, 2016.
ISNAD ULUÇAM, Enis - BAKAR, Elvan. "The effect of proanthocyanidin on formaldehyde-induced toxicity in rat testes". Turkish Journal of Medical Sciences 46/1 (2016), 185-193.
Sayfa Oluşturulma Tarihi
23-04-2024 3:23

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