Yıl: 2017 Cilt: 7 Sayı: 1 Sayfa Aralığı: 26 - 32 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

The Role of Maternal Oxidative Stress, Iron/Zinc, Copper/Zinc Ratios and Trace Element Levels in the Pathogenesis of Preeclampsia

Öz:
Purpose:Preeclampsia (PE) is a complex disease and the underlying mechanisms are not known, yet. It is well known that oxidative stress and trace elements play a role in the pathogenesis of various diseases. Several studies have shown that the levels and proportions of trace elements are closely related to the severity of the disease. The aim of the study was to investigate the changes in some characteristics parameters, serum zinc, iron, copper levels, and copper/zinc and iron/zinc ratios and plasma lipid peroxidation levels in patients with mild and severe preeclampsia
Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Preeklampsinin Patogenezinde Maternal Oksidatif Stres, Demir/Çinko, Bakır/Çinko Oranları ve Eser Element Düzeylerinin Rolü

Öz:
Amaç: Preeklampsi (PE) kompleks bir hastalıktır ve hastalığın patogenezinde yer alan mekanizmalar henüz aydınlatılamamıştır. Oksidatif stres ve eser elementlerin çeşitli hastalıkların patogenezinde rol oynadığı iyi bilinmektedir. Yapılan çeşitli çalışmalarda, eser elementlerin düzeylerinin ve oranlarının, hastalığın şiddeti ile yakından ilişkili olduğunu göstermiştir. Bu çalışmanın amacı, hafif ve şiddetli preeklamptik hastalarda bazı karakteristik özelliklerin, serum çinko, demir, bakır düzeyleri, bakır/çinko ve demir/çinko oranları ile plazma lipid peroksidasyon düzeylerini değişikliklerini araştırmaktır
Anahtar Kelime:

Konular: Genel ve Dahili Tıp
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Lima VJ, Andrade CR, Ruschi GE, Sass N. Serum lipid levels in pregnancies complicated by preeclampsia. Sao Paulo Med J. 2011;129:73-6.
  • 2. Peter Stein T, Scholl TO, Schluter MD, Leskiw MJ, Chen X, Spur BW, Rodriguez A. Oxidative stress early in pregnancy and pregnancy outcome. Free Radic Res. 2008;42(10):841-48.
  • 3. Ilhan N, Ilhan N, Simsek M. The changes of trace elements, malondialdehyde levels and superoxide dismutase activities in pregnancy with or without preeclampsia. Clin Biochem 2002;35:393-97.
  • 4. Kharb S. Lipid peroxidation in pregnancy with preeclampsia and diabetes. Gynecol Obstet Invest. 2000;50:113-16.
  • 5. Walsh SW, Wang Y. Secretion of lipid peroxides by the human placenta. Am J Obstet Gynecol. 1993;169:1462-466.
  • 6. Wiktor H, Kankofer M. Assessment of lipid peroxidation intensifi cation in normal and preeclamptic placentas. Ginekol Pol. 2001;72:1217-221.
  • 7. Sikkema JM, Van Rijn BB, Franx A, et al. Placental superoxide is increased in preeclampsia. Placenta 2001;22:304-308.
  • 8. Chen G, Wilson R, Cumming G, Walker JJ, Smith WE, McKillop JH. Prostacyclin, tromboxane and antioxidant levels in pregnancy-induced hypertension. Eur J Obstet Gynecol Reprod Biol 1993;50:243.
  • 9. Atamer Y, Kocyigit Y, Yokus B, Atamer A, Erden AC. Lipid peroxidation, antioxidant defense, status of trace metals and leptin levels in preeclampsia. European Journal of Obstetrics & Gynecology and Reproductive Biology 2005;119:60-6.
  • 10. Aydemir B, Akdemir R, Vatan MB, Cinemre FB, Cinemre H, et al. The Circulating Levels of Selenium, Zinc, Midkine, Some Infl ammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture. Biol Trace Elem Res. 2015;167(2): 179-86.
  • 11. Kiziler AR, Aydemir B, Guzel S, Alici B, Ataus S, Tuna MB, Durak H, Kilic M. May the level and ratio changes of trace elements be utilized in identifi cation of disease progression and grade in prostatic cancer? Trace Elements and Electrolytes. 2010; 27(2): 65-72.
  • 12. Aydemir B, Kızıler AR, Onaran I, Alıcı B, Ozkara H, Akyolcu MC. Impact of Cu and Fe concentrations on oxidative damage in male infertility. Biol Trace Elem Res 2006;112 (3):193-204.
  • 13. Ahsan T, Banu S, Nahar Q, Ahsan M, Khan MN, Islam SN. Serum trace elements levels in preeclampsia and eclampsia: correlation with the pregnancy disorder. Biol Trace Elem Res. 2013;152(3):327-32.
  • 14. Fenzl V, Flegar-Mestric Z, Perkov S, Andrisic L, Tatzber F, Zarkovic N, Duic Z. Trace elements and oxidative stress in hypertensive disorders of pregnancy. Arch Gynecol Obstet. 2013;287(1):19-24.
  • 15. Bakacak M, Kılınç M, Serin S, Ercan Ö, Köstü B, Avcı F, Kıran H, Kıran G. Changes in Copper, Zinc,and Malondialdehyde Levels and Superoxide DismutaseActivities in Pre-Eclamptic Pregnancies. Med Sci Monit. 2015;21:2414-420
  • 16. Serdar Z, Gur E, Develioglu O. Serum iron and copper status and oxidative stress in severe and mild preeclampsia. Cell Biochem Funct. 2006;24(3):209-15.
  • 17. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Obstet Gynecol 2002; 99:159- 67.
  • 18. Bolte AC, Van Geijn HP, Dekker GA. Management and monitoring of severe preeclampsia. Eur J Obstet Gynecol Reprod Biol 2001;96: 8-20.
  • 19. Buege JA, Aust STD. Microsomal lipid peroxidation. Methods Enzymol 1978;52:302-10.
  • 20. Rafeeinia A, Tabandeh A, Khajeniazi S, Marjani AJ: Serum copper, zinc an¬d lipid peroxidation in pregnant women with preeclampsia in Gorgan. Open Biochem J, 2014; 8: 83-8.
  • 21. Cavalca V, Cighetti G, Bamonti F, et al. Oxidative stress and homocysteine in coronary artery disease. Clin Chem. 2001; 47(5): 887-92.
  • 22. Pucheu S, Coundray C, Vanzetto G, Favier A, De Liris J. Assessment of radical activity during the acute phase of myocardial infarction following fi brinolysis: utility of assaying plasma malondialdehyde. Free Radic Biol Med. 1995; 19: 873- 81.
  • 23. Soydinc S, Celik A, Demiryurek S, et al. The relationship between oxidative stress, nitric oxide, and coronary artery disease. Eur J Gen Med. 2007; 4(2): 62-6.
  • 24. Aymelek G, Erten D, Aslan S et al. Lipid peroxidation and antioxidant status in blood and tissue of malignant breast tumor and bening breast disease. Cell Biol Int. 2006; 30: 376-80.
  • 25. Valko M, Rhodes CJ, Moncol J et al. Free radicals, metals, and antioxidants in oxidative stress-induced cancer. Chem Biol Interact. 2006; 160: 1-40.
  • 26. Kosar F, Sahin I, Acıkgoz N, Aksoy Y, Kucukbay Z, Cehreli S. Signifi cance of serum trace element status in patients with rheumatic heart disease: a prospective study. Biol Trace Elem Res. 2005; 107: 1-10.
  • 27. Ozturk P, KurutasEB, Atasever A. Copper/zinc and copper/ selenium ratios, and oxidative stress as biochemical markers in recurrent aphthous stomatitis. J Trace Elem Med Biol. 2013; 27:312-16.
APA CİNEMRE F, CİNEMRE H, KARTAL N, GÜLYAŞAR T, Yildiz M, TÜTEN A, YILMAZ N, KIZILER A, Abali R, Akdemir N, Aydemir B (2017). The Role of Maternal Oxidative Stress, Iron/Zinc, Copper/Zinc Ratios and Trace Element Levels in the Pathogenesis of Preeclampsia. , 26 - 32.
Chicago CİNEMRE Fatma Behice Serinkan,CİNEMRE Hakan,KARTAL Nagihan,GÜLYAŞAR Tevfik,Yildiz Mustafa,TÜTEN ABDULLAH,YILMAZ Nevin,KIZILER Ali Rıza,Abali Remzi,Akdemir Nermin,Aydemir Birsen The Role of Maternal Oxidative Stress, Iron/Zinc, Copper/Zinc Ratios and Trace Element Levels in the Pathogenesis of Preeclampsia. (2017): 26 - 32.
MLA CİNEMRE Fatma Behice Serinkan,CİNEMRE Hakan,KARTAL Nagihan,GÜLYAŞAR Tevfik,Yildiz Mustafa,TÜTEN ABDULLAH,YILMAZ Nevin,KIZILER Ali Rıza,Abali Remzi,Akdemir Nermin,Aydemir Birsen The Role of Maternal Oxidative Stress, Iron/Zinc, Copper/Zinc Ratios and Trace Element Levels in the Pathogenesis of Preeclampsia. , 2017, ss.26 - 32.
AMA CİNEMRE F,CİNEMRE H,KARTAL N,GÜLYAŞAR T,Yildiz M,TÜTEN A,YILMAZ N,KIZILER A,Abali R,Akdemir N,Aydemir B The Role of Maternal Oxidative Stress, Iron/Zinc, Copper/Zinc Ratios and Trace Element Levels in the Pathogenesis of Preeclampsia. . 2017; 26 - 32.
Vancouver CİNEMRE F,CİNEMRE H,KARTAL N,GÜLYAŞAR T,Yildiz M,TÜTEN A,YILMAZ N,KIZILER A,Abali R,Akdemir N,Aydemir B The Role of Maternal Oxidative Stress, Iron/Zinc, Copper/Zinc Ratios and Trace Element Levels in the Pathogenesis of Preeclampsia. . 2017; 26 - 32.
IEEE CİNEMRE F,CİNEMRE H,KARTAL N,GÜLYAŞAR T,Yildiz M,TÜTEN A,YILMAZ N,KIZILER A,Abali R,Akdemir N,Aydemir B "The Role of Maternal Oxidative Stress, Iron/Zinc, Copper/Zinc Ratios and Trace Element Levels in the Pathogenesis of Preeclampsia." , ss.26 - 32, 2017.
ISNAD CİNEMRE, Fatma Behice Serinkan vd. "The Role of Maternal Oxidative Stress, Iron/Zinc, Copper/Zinc Ratios and Trace Element Levels in the Pathogenesis of Preeclampsia". (2017), 26-32.
APA CİNEMRE F, CİNEMRE H, KARTAL N, GÜLYAŞAR T, Yildiz M, TÜTEN A, YILMAZ N, KIZILER A, Abali R, Akdemir N, Aydemir B (2017). The Role of Maternal Oxidative Stress, Iron/Zinc, Copper/Zinc Ratios and Trace Element Levels in the Pathogenesis of Preeclampsia. Sakarya Tıp Dergisi, 7(1), 26 - 32.
Chicago CİNEMRE Fatma Behice Serinkan,CİNEMRE Hakan,KARTAL Nagihan,GÜLYAŞAR Tevfik,Yildiz Mustafa,TÜTEN ABDULLAH,YILMAZ Nevin,KIZILER Ali Rıza,Abali Remzi,Akdemir Nermin,Aydemir Birsen The Role of Maternal Oxidative Stress, Iron/Zinc, Copper/Zinc Ratios and Trace Element Levels in the Pathogenesis of Preeclampsia. Sakarya Tıp Dergisi 7, no.1 (2017): 26 - 32.
MLA CİNEMRE Fatma Behice Serinkan,CİNEMRE Hakan,KARTAL Nagihan,GÜLYAŞAR Tevfik,Yildiz Mustafa,TÜTEN ABDULLAH,YILMAZ Nevin,KIZILER Ali Rıza,Abali Remzi,Akdemir Nermin,Aydemir Birsen The Role of Maternal Oxidative Stress, Iron/Zinc, Copper/Zinc Ratios and Trace Element Levels in the Pathogenesis of Preeclampsia. Sakarya Tıp Dergisi, vol.7, no.1, 2017, ss.26 - 32.
AMA CİNEMRE F,CİNEMRE H,KARTAL N,GÜLYAŞAR T,Yildiz M,TÜTEN A,YILMAZ N,KIZILER A,Abali R,Akdemir N,Aydemir B The Role of Maternal Oxidative Stress, Iron/Zinc, Copper/Zinc Ratios and Trace Element Levels in the Pathogenesis of Preeclampsia. Sakarya Tıp Dergisi. 2017; 7(1): 26 - 32.
Vancouver CİNEMRE F,CİNEMRE H,KARTAL N,GÜLYAŞAR T,Yildiz M,TÜTEN A,YILMAZ N,KIZILER A,Abali R,Akdemir N,Aydemir B The Role of Maternal Oxidative Stress, Iron/Zinc, Copper/Zinc Ratios and Trace Element Levels in the Pathogenesis of Preeclampsia. Sakarya Tıp Dergisi. 2017; 7(1): 26 - 32.
IEEE CİNEMRE F,CİNEMRE H,KARTAL N,GÜLYAŞAR T,Yildiz M,TÜTEN A,YILMAZ N,KIZILER A,Abali R,Akdemir N,Aydemir B "The Role of Maternal Oxidative Stress, Iron/Zinc, Copper/Zinc Ratios and Trace Element Levels in the Pathogenesis of Preeclampsia." Sakarya Tıp Dergisi, 7, ss.26 - 32, 2017.
ISNAD CİNEMRE, Fatma Behice Serinkan vd. "The Role of Maternal Oxidative Stress, Iron/Zinc, Copper/Zinc Ratios and Trace Element Levels in the Pathogenesis of Preeclampsia". Sakarya Tıp Dergisi 7/1 (2017), 26-32.