Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease

ALSANCAK, Yakup; sivri, serkan; ÖZKAN, Selçuk; KIZILTUNÇ, Emrullah; SEZENÖZ, Burak; Demir Alsancak, Aybüke; TAÇOY, GÜLTEN

Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease

Emrullah KIZILTUNÇ, (Ankara Numune Training and Research Hospital, Clinic of Cardiology, Ankara, Turkey)

Yakup ALSANCAK, (Ankara Atatürk Training and Research Hospital, Clinic of Cardiology, Ankara, Turkey)

Burak SEZENÖZ, (Ankara Gazi Mustafa Kemal State Hospital, Clinic of Cardiology, Ankara, Turkey)

Selçuk ÖZKAN, (Ankara Keçiören Training and Research Hospital, Clinic of Cardiology, Ankara, Turkey)

Serkan SİVRİ, (Ankara Atatürk Training and Research Hospital, Clinic of Cardiology, Ankara, Turkey)

Aybüke Demir ALSANCAK, (Ankara Numune Training and Research Hospital, Clinic of Family Medicine, Turkey)

Gülten TAÇOY (Gazi University Faculty of Medicine, Department of Cardiology, Ankara, Turkey)

Koşuyolu Kalp Dergisi

1 0

Yıl: 2017 Cilt: 20 Sayı: 1 Sayfa Aralığı: 30 - 35 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease

Öz:

Giriş: Kan dolaşımında bulunan monosit sayısı yeni aterosklerotik plak oluşumunda öngörücüdür. Bununlabirlikte yüksek dansiteli lipoprotein kolesterol (HDL) düzeyleri ile ateroskleroz arasında güçlü bir negatifilişki vardır. Bu çalışmada, monosit sayısı/HDL oranıyla koroner arter hastalığı ciddiyeti arasındaki ilişkiyideğerlendirmeyi amaçladık.Hastalar ve Yöntem: Koroner anjiyografi yapılan toplam 760 hasta çalışmaya dahil edildi. Koroner aterosklerozciddiyeti Gensini skorlama sistemi kullanılarak değerlendirildi ve hastalar Gensini skorlarına göre yüksek(> 20) ve düşük (< 20) olarak iki gruba ayrıldı. Bazal karakteristik özellikler ve laboratuvar parametrelerikaydedilerek yüksek ve düşük Gensini skoru olan hastalar arasında karşılaştırıldı.Bulgular: Hipertansiyon, diabetes mellitus, hiperlipidemi, ileri yaş ve sigara içiciliği yüksek Gensini skoruolan hastalarda daha fazlaydı. Açlık kan şekeri, kreatinin düzeyleri ve monosit/HDL oranı düşük Gensiniskoru olan hastalarda yüksek Gensini skoru olanlara kıyasla daha düşüktü. Lojistik regresyon analizinde ileriyaş, açlık kan şekeri, hiperlipidemi, aile öyküsü ve erkek cinsiyetin yüksek Gensini skoru için bağımsızparametreler olduğu gözlendi. Monosit/HDL oranının, Gensini skoruyla korele olduğu (p< 0.001) ancak bukorelasyonun çok zayıf olduğu tespit edildi (Spearman's Rho: 0.159).Sonuç: Monosit/HDL oranı ile Gensini skoruyla elde edilen ateroskleroz yaygınlığı arasında zayıf da olsa birilişki izlenmiştir. Ancak Monosit/HDL oranı ve aterosklerotik kalp hastalığı arasındaki ilişkiyi belirlemek içindaha fazla klinik çalışmaya ihtiyaç vardır.

Anahtar Kelime:

Konular: Cerrahi

Monosit Sayısı/HDL Oranı ile Koroner Arter Hastalığının Ciddiyeti ve Yaygınlığı Arasındaki İlişki

Öz:

Introduction: Circulating monocyte count is predictive of new atherosclerotic plaque development. Inaddition, there is a strong inverse relationship between high-density lipoprotein (HDL) cholesterol andatherosclerosis. We aimed to investigate the relationship between the monocyte/HDL cholesterol ratio andseverity of coronary artery disease.Patients and Methods: A total of 760 patients who underwent coronary angiography were included inthe study. The severity of coronary atherosclerosis was calculated by the Gensini score, and the patientswere grouped as having low (< 20) and high (> 20) Gensini scores. Baseline characteristics and laboratoryparameters were recorded and compared between patients with low and high Gensini scores.Results: Hypertension, diabetes mellitus, hyperlipidaemia, advanced age and smoking were more commonin patients with a high Gensini score. Fasting blood glucose levels, creatinine levels and monocyte/HDLcholesterol ratio were significantly lower in patients with a low Gensini score than in those with a high Gensiniscore. Logistic regression analysis revealed that older age, fasting blood glucose levels, hyperlipidaemia,family history of coronary artery disease and male gender were independent predictors of a high Gensiniscore. We observed a correlation between the monocyte/HDL cholesterol ratio and Gensini score (p< 0.001).However, this correlation was weak (Spearman's rho = 0.159).Conclusion: We observed a positive but weak correlation between the monocyte/HDL cholesterol; ratio andincreased coronary atherosclerotic burden, as calculated by Gensini scoring. Further studies are required todemonstrate the relationship between the monocyte/HDL cholesterol ratio and atherosclerotic cardiovasculardisease.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KIZILTUNÇ E, ALSANCAK Y, SEZENÖZ B, ÖZKAN S, sivri s, Demir Alsancak A, TAÇOY G (2017). Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease. , 30 - 35.
Chicago	KIZILTUNÇ Emrullah,ALSANCAK Yakup,SEZENÖZ Burak,ÖZKAN Selçuk,sivri serkan,Demir Alsancak Aybüke,TAÇOY GÜLTEN Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease. (2017): 30 - 35.
MLA	KIZILTUNÇ Emrullah,ALSANCAK Yakup,SEZENÖZ Burak,ÖZKAN Selçuk,sivri serkan,Demir Alsancak Aybüke,TAÇOY GÜLTEN Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease. , 2017, ss.30 - 35.
AMA	KIZILTUNÇ E,ALSANCAK Y,SEZENÖZ B,ÖZKAN S,sivri s,Demir Alsancak A,TAÇOY G Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease. . 2017; 30 - 35.
Vancouver	KIZILTUNÇ E,ALSANCAK Y,SEZENÖZ B,ÖZKAN S,sivri s,Demir Alsancak A,TAÇOY G Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease. . 2017; 30 - 35.
IEEE	KIZILTUNÇ E,ALSANCAK Y,SEZENÖZ B,ÖZKAN S,sivri s,Demir Alsancak A,TAÇOY G "Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease." , ss.30 - 35, 2017.
ISNAD	KIZILTUNÇ, Emrullah vd. "Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease". (2017), 30-35.

APA	KIZILTUNÇ E, ALSANCAK Y, SEZENÖZ B, ÖZKAN S, sivri s, Demir Alsancak A, TAÇOY G (2017). Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease. Koşuyolu Kalp Dergisi, 20(1), 30 - 35.
Chicago	KIZILTUNÇ Emrullah,ALSANCAK Yakup,SEZENÖZ Burak,ÖZKAN Selçuk,sivri serkan,Demir Alsancak Aybüke,TAÇOY GÜLTEN Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease. Koşuyolu Kalp Dergisi 20, no.1 (2017): 30 - 35.
MLA	KIZILTUNÇ Emrullah,ALSANCAK Yakup,SEZENÖZ Burak,ÖZKAN Selçuk,sivri serkan,Demir Alsancak Aybüke,TAÇOY GÜLTEN Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease. Koşuyolu Kalp Dergisi, vol.20, no.1, 2017, ss.30 - 35.
AMA	KIZILTUNÇ E,ALSANCAK Y,SEZENÖZ B,ÖZKAN S,sivri s,Demir Alsancak A,TAÇOY G Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease. Koşuyolu Kalp Dergisi. 2017; 20(1): 30 - 35.
Vancouver	KIZILTUNÇ E,ALSANCAK Y,SEZENÖZ B,ÖZKAN S,sivri s,Demir Alsancak A,TAÇOY G Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease. Koşuyolu Kalp Dergisi. 2017; 20(1): 30 - 35.
IEEE	KIZILTUNÇ E,ALSANCAK Y,SEZENÖZ B,ÖZKAN S,sivri s,Demir Alsancak A,TAÇOY G "Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease." Koşuyolu Kalp Dergisi, 20, ss.30 - 35, 2017.
ISNAD	KIZILTUNÇ, Emrullah vd. "Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease". Koşuyolu Kalp Dergisi 20/1 (2017), 30-35.