Yıl: 2016 Cilt: 46 Sayı: 3 Sayfa Aralığı: 872 - 876 Metin Dili: Diğer İndeks Tarihi: 29-07-2022

PaCaHa inhibits proliferation of human cancer cells in vitro

Öz:
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Anahtar Kelime:

Konular: Cerrahi

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Öz:
Background/aim: The aim of this study was to investigate the antiproliferative and cytotoxic effects of a newly synthesized molecule named paracetamol acetohydroxamic acid (PaCaHa) on human neoplastic cell lines. Materials and methods: A549, CRL 2923, HeLa, and ARPE were treated with various concentrations of PaCaHa and DMSO (vehicle control). The cytotoxic/cytostatic effects of PaCaHa were determined after a 24-h incubation period and compared to the DMSO control. The cytotoxic and antiproliferative effects were determined by the trypan blue dye exclusion and MTT methods. Results: A higher susceptibility to PaCaHA was found in CRL 2923 and HeLa cells, while A549 and ARPE cells were less responsive to PaCaHa. The percent of cytotoxicity resulting from 400 µg/mL of PaCaHa were >90 for CRL-2923 and HeLa, 68 for A549, and 64 for ARPE cells. The cytotoxic difference between CRL-2923/HeLa and ARPE/A549 cells was significant (P < 0.05). Conclusion: PaCaHa showed dose dependent cytotoxic and antiproliferative effects on three distinct human cancer cell lines. The differential effect of PaCaHa on different cancer cell lines suggests that PaCaHa could have a potential antitumor effect on specific cancer types. These results support further comprehensive studies on PaCaHa and its derivatives.
Anahtar Kelime:

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
APA Eksi S, EJDER N, YILMAZ F, ERTÜRK A, SANDALLI C (2016). PaCaHa inhibits proliferation of human cancer cells in vitro. , 872 - 876.
Chicago Eksi Saliha,EJDER NEBAHAT,YILMAZ Fatih,ERTÜRK AYŞE,SANDALLI Cemal PaCaHa inhibits proliferation of human cancer cells in vitro. (2016): 872 - 876.
MLA Eksi Saliha,EJDER NEBAHAT,YILMAZ Fatih,ERTÜRK AYŞE,SANDALLI Cemal PaCaHa inhibits proliferation of human cancer cells in vitro. , 2016, ss.872 - 876.
AMA Eksi S,EJDER N,YILMAZ F,ERTÜRK A,SANDALLI C PaCaHa inhibits proliferation of human cancer cells in vitro. . 2016; 872 - 876.
Vancouver Eksi S,EJDER N,YILMAZ F,ERTÜRK A,SANDALLI C PaCaHa inhibits proliferation of human cancer cells in vitro. . 2016; 872 - 876.
IEEE Eksi S,EJDER N,YILMAZ F,ERTÜRK A,SANDALLI C "PaCaHa inhibits proliferation of human cancer cells in vitro." , ss.872 - 876, 2016.
ISNAD Eksi, Saliha vd. "PaCaHa inhibits proliferation of human cancer cells in vitro". (2016), 872-876.
APA Eksi S, EJDER N, YILMAZ F, ERTÜRK A, SANDALLI C (2016). PaCaHa inhibits proliferation of human cancer cells in vitro. Turkish Journal of Medical Sciences, 46(3), 872 - 876.
Chicago Eksi Saliha,EJDER NEBAHAT,YILMAZ Fatih,ERTÜRK AYŞE,SANDALLI Cemal PaCaHa inhibits proliferation of human cancer cells in vitro. Turkish Journal of Medical Sciences 46, no.3 (2016): 872 - 876.
MLA Eksi Saliha,EJDER NEBAHAT,YILMAZ Fatih,ERTÜRK AYŞE,SANDALLI Cemal PaCaHa inhibits proliferation of human cancer cells in vitro. Turkish Journal of Medical Sciences, vol.46, no.3, 2016, ss.872 - 876.
AMA Eksi S,EJDER N,YILMAZ F,ERTÜRK A,SANDALLI C PaCaHa inhibits proliferation of human cancer cells in vitro. Turkish Journal of Medical Sciences. 2016; 46(3): 872 - 876.
Vancouver Eksi S,EJDER N,YILMAZ F,ERTÜRK A,SANDALLI C PaCaHa inhibits proliferation of human cancer cells in vitro. Turkish Journal of Medical Sciences. 2016; 46(3): 872 - 876.
IEEE Eksi S,EJDER N,YILMAZ F,ERTÜRK A,SANDALLI C "PaCaHa inhibits proliferation of human cancer cells in vitro." Turkish Journal of Medical Sciences, 46, ss.872 - 876, 2016.
ISNAD Eksi, Saliha vd. "PaCaHa inhibits proliferation of human cancer cells in vitro". Turkish Journal of Medical Sciences 46/3 (2016), 872-876.