Mehmet Can GİRGİN
(İstanbul Eğitim ve Araştırma Hastanesi, Acil Tıp Kliniği, İstanbul, Türkiye)
(Dokuz Eylül Üniversitesi, Tıp Fakültesi, Acil Tıp Anabilim Dalı, İzmir, Türkiye)
Mualla Aylin ARICI
(Dokuz Eylül Üniversitesi, Tıp Fakültesi, Farmakoloji Bölümü, İzmir, Türkiye)
(Dokuz Eylül Üniversitesi, Tıp Fakültesi, Acil Tıp Anabilim Dalı, İzmir, Türkiye)
(Ahi Evran Üniversitesi Eğitim Araştırma Hastanesi Acil Tıp Anabilim Dalı, Kırşehir, Türkiye)
(Dokuz Eylül Üniversitesi Halk Sağlığı AD, İzmir, Türkiye)
(Dokuz Eylül Üniversitesi, Tıp Fakültesi, Farmakoloji Bölümü, İzmir, Türkiye)
Yıl: 2016Cilt: 46Sayı: 4ISSN: 1300-0144 / 1303-6165Sayfa Aralığı: 945 - 952İngilizce

181 0
Emergency department visits caused by adverse drug reactions: results of a Turkish university hospital
Background/aim: We aimed to evaluate adverse drug reaction (ADR)-related emergency department (ED) visits in the ED of the Dokuz Eylül University Hospital prospectively. Materials and methods: Patients who were admitted to the ED during 1-week periods of four different seasons between July 2010 and April 2011 were enrolled. Demographics of patients, previous ADR history, clinical progress, and outcomes were recorded. Causality assessment was done according to World Health Organization Uppsala Monitoring Centre categories. ADRs were categorized as certain, probable, or possible. Results: Patients who were on medications (26.5%, n = 1838) were evaluated for ADR-related ED admissions. ADRs accounted for 5.9% of cases (n = 108). The most frequently affected systems were the gastrointestinal (35.2%, n = 38), dermatological (23.1%, n = 25), and hematological (10.2%, n = 11) systems (7.4%, n = 8). The most common causes of ADRs were antiinfectives (31.6%, n = 33). Amoxicillin, Coumadin, and paracetamol were the most common medications that caused ADRs. Conclusion: Nearly 6% of the admissions were ADR-related. ADRs should always be considered when patients who are on medication are admitted to the ED. Multicenter epidemiologic studies are required to know the real rates of ADR cases in EDs in Turkey
Fen > Tıp > Cerrahi
DergiAraştırma MakalesiErişime Açık
  • 1. Edwards IR, Aronson JK. Adverse drug reactions: definitions, diagnosis, and management. Lancet 2000; 356: 1255-1259.
  • 2. Wu TY, Jen MH, Bottle A, Molokhia M, Aylin P, Bell D, Majeed A. Ten-year trends in hospital admissions for adverse drug reactions in England 1999-2009. J R Soc Med 2010; 103: 239- 250.
  • 3. Rehan HS, Chopra D, Kakkar AK. Physician’s guide to pharmacovigilance: terminology and causality assessment. Eur J Intern Med 2009; 20: 3-8.
  • 4. Capuano A, Irpino A, Gallo M, Ferrante L, Illiano ML, Rinaldi B, Filippelli A, Rossi F. Regional surveillance of emergencydepartment visits for outpatient adverse drug events. Eur J Clin Pharmacol 2009; 65: 721-728.
  • 5. Patel KJ, Kedia MS, Bajpai D, Mehta SS, Kshirsagar NA, Gogtay NJ. Evaluation of the prevalence and economic burden of adverse drug reactions presenting to the medical emergency department of a tertiary referral centre: a prospective study. BMC Clin Pharmacol 2007; 7: 8.
  • 6. De Paepe P, Petrovic M, Outtier L, Van Maele G, Buylaert W. Drug interactions and adverse drug reactions in the older patients admitted to the emergency department. Acta Clin Belg 2013; 68: 15-21.
  • 7. Queneau P, Bannwarth B, Carpentier F, Guliana JM, Bouget J, Trombert B, Leverve X, Lapostolle F, Borron SW, Adnet F et al. Emergency department visits caused by adverse drug events: results of a French survey. Drug Saf 2007; 30: 81-88.
  • 8. Wilbur K, Hazi H, El-Bedawi A. Drug-related hospital visits and admissions associated with laboratory or physiologic abnormalities-a systematic-review. PLoS One 2013; 27; 8: e66803.
  • 9. Lazarou J, Pomeranz BH, Corey PN. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA 1998; 279: 1200-1205.
  • 10. Üstünes L, editor. RxMediaPharma İnteraktif İlaç Bilgi Kaynağı. İzmir, Turkey: GEMAŞ; 2011.
  • 11. Klasco RK, editor. DRUGDEX® System. Greenwood Village, CO, USA: Thomson Micromedex (Vol. 149 expires 09/2011).
  • 12. Ma J, Wang Y, Gao M, Meng Q, Liu J. Adverse drug reactions as the cause of emergency department admission of patients aged 80 years and older. Eur J Intern Med 2012; 23: e162-163.
  • 13. Roulet L, Asseray N, Dary M, Chiffoleau A, Potel G, Ballereau F. Implementing a clinical pharmacy survey of adverse drug events in a French emergency department. Int J Clin Pharm 2012; 34: 902-910.
  • 14. Chen YC, Fan JS, Hsu TF, Chen MH, Huang HH, Cheng KW, Yen DH, Huang MS, Lee CH, Chen LK et al. Detection of patients presenting with adverse drug events in the emergency department. Intern Med J 2012; 42: 651-657.
  • 15. Andreazza RS, Silveira De Castro M, Sippel Köche P, Heineck I. Causes of drug-related problems in the emergency room of a hospital in southern Brazil. Gac Sanit 2011; 25: 501-506.
  • 16. Hafner JW Jr, Belknap SM, Squillante MD, Bucheit KA. Adverse drug events in emergency department patients. Ann Emerg Med 2002; 39: 258-267.
  • 17. Zanocchi M, Tibaldi V, Amati D, Francisetti F, Martinelli E, Gonella M, Cerrato F, Ponte E, Luppino A, Bardelli B et al. Adverse drug reactions as cause of visit to the emergency department: incidence, features and outcomes. Recenti Prog Med 2006; 97: 381-388 (in Italian with English abstract).
  • 18. Okezie EO, Olufunmilayo F. Adverse drug reactions reporting by physicians in Ibadan, Nigeria. Pharmacoepidemiol Drug Saf 2008; 17: 517-522.
  • 19. Brahma DK, Wahlang JB, Marak MD, Sangma MC. Adverse drug reactions in the elderly. J Pharmacol Pharmacother 2013; 4: 91-94.
  • 20. Zaki SA. Adverse drug reaction and causality assessment scales. Lung India 2011; 28: 152-153.
  • 21. Juntti-Patinen L, Kuitunen T, Pere P, Neuvonen PJ. Drugrelated visits to a district hospital emergency room. Basic Clin Pharmacol Toxicol 2006; 98: 212-217.
  • 22. Capuano A, Motola G, Russo F, Avolio A, Filippelli A, Rossi F, Mazzeo F. Adverse drug events in two emergency departments in Naples, Italy: an observational study. Pharmacol Res 2004; 50: 631-636.
  • 23. Prince BS, Goetz CM, Rihn TL, Olsky M. Drug-related emergency department visits and hospital admissions. Am J Hosp Pharm 1992; 49: 1696-1700.
  • 24. Mollahaliloglu S, Alkan A, Donertas B, Ozgulcu S, Akici A. Assessment of antibiotic prescribing at different hospitals and primary health care facilities. Saudi Pharm J 2013; 21: 281-291.
  • 25. Smith W. Adverse drug reactions - allergy? side-effect? intolerance? Aust Fam Physician 2013; 42: 12-16.
  • 26. Becker ML, Kallewaard M, Caspers PW, Visser LE, Leufkens HG, Stricker BH. Hospitalisations and emergency department visits due to drug-drug interactions: a literature review. Pharmacoepidemiol Drug Saf 2007; 16: 641-651.
  • 27. Alomar MJ. Factors affecting the development of adverse drug reactions (Review article). Saudi Pharm J 2014; 22: 83-94.
  • 28. Shepherd G, Mohorn P, Yacoub K, May DW. Adverse drug reaction deaths reported in United States vital statistics, 1999- 2006. Ann Pharmacother 2012; 46: 169-175.
  • 29. Noblat AC, Noblat LA, Toledo LA, Santos Pde M, Oliveira MG, Tanajura GM, Spinola SU, Almeida JR. Prevalence of hospital admission due to adverse drug reaction in Salvador, Bahia. Rev Assoc Med Bras 2011; 57: 42-45 (in Portuguese with English abstract).

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