KORHAN SOYLU
(Girilmedi)
Gökhan AKSAN
(Girilmedi)
GÖKAY NAR
(Department of Cardiology, Aksaray State Hospital; Aksaray-Turkey Departments of 4Cardiology and Radiology, Samsun Training and Research Hospital; Samsun-Turkey)
Metin ÖZDEMİR
(Girilmedi)
OKAN GÜLEL
(Girilmedi)
SİNAN İNCİ
(Department of Cardiology, Aksaray State Hospital; Aksaray-Turkey Departments of 4Cardiology and 5Radiology, Samsun Training and Research Hospital; Samsun-Turkey)
Aytekin AKSAKAL
(Girilmedi)
Ayşegül İdil SOYLU
(Girilmedi)
ÖZCAN YILMAZ
(Girilmedi)
Yıl: 2015Cilt: 15Sayı: 6ISSN: 2149-2263 / 2149-2271Sayfa Aralığı: 450 - 455İngilizce

99 1
Serum neutrophil gelatinase-associated lipocalin levels are correlated with the complexity and the severity of atherosclerosis in acute coronary syndrome
Amaç: Neutrophil gelatinase-associated lipocalin (NGAL) nötrofillerden salınan yeni bir enflamatuvar belirteçtir. Bu çalışmada ST elevasyonsuz akut koroner sendromlu (NSTE-ACS) hastalardaki klinik ve anjiyografik risk skorları ile NGAL seviyesi arasındaki ilişki araştırılmıştır. Yöntemler: Çalışmaya koroner anjiyografi uygulanan 47 NSTE-ACS hastası ile stabil angina nedeniyle koroner anjiyografi yapılan ve koroner arterleri normal saptanan 45 kontrol hastası dahil edildi. Klinik risk değerlendirmesi amacıyla GRACE risk skoru, anjiyografik risk değerlendirmesi amacıyla da SYNTAX ve Gensini risk skorları kullanıldı. Başvuru esnasında hastalardan alınan kan örneklerinden ELİSA yöntemi ile serum NGAL düzeyi hesaplandı. Bulgular: Serum NGAL seviyesi NSTE-ACS grubunda kontrol grubuna göre anlamlı olarak daha yüksekti (112,3±49,6 ng/mL'ye karşın 58,1±24,3 ng/mL, p<0,001). Serum NGAL düzeyleri ile GRACE risk skoru (r=0,533 ve p<0,001), SYNTAX (r=0,395 ve p=0,006) ve GENSİNİ risk skorları (r=0,575 ve p<0,001) arasında anlamlı pozitif korelasyon vardı. NGAL seviyesi orta-yüksek SYNTAX (>22) grupta düşük SYNTAX (<=22) gruba göre anlamlı şekilde yüksekti (143±29,5 ng/mL'ye karşın 98,7±43,2 ng/mL, p=0,001). Sonuç: Çalışmamızda NGAL seviyesi NSTE-ACS hastalarındaki lezyon kompleksitesi ve koroner arter hastalığının yaygınlığı ile pozitif korelasyon göstermiştir. Başvuru sırasındaki serum NGAL seviyesi NSTE-ACS hastalarındaki artmış aterosklerotik yük ile ilişkilidir.
Fen > Tıp > Kalp ve Kalp Damar Sistemi
DergiAraştırma MakalesiErişime Açık
  • 1. Ikonomidis I, Michalakeas CA, Parissis J, Paraskevaidis I, Ntai K, Papadakis I, et al. Inflammatory markers in coronary artery disease. Biofactors 2012; 38: 320-8. [CrossRef]
  • 2. Kjeldsen L, Johnsen AH, Sengelov H, Borregaard N. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem 1993; 268: 10425-32.
  • 3. Yndestad A, Landrø L, Ueland T, Dahl CP, Flo TH, Vinge LE, et al. Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure. Eur Heart J 2009; 30: 1229-36. [CrossRef]
  • 4. Ding L, Hanawa H, Ota Y, Hasegawa G, Hao K, Asami F, et al. Lipocalin-2 neutrophil gelatinase-B associated lipocalin is strongly induced in hearts of rats with autoimmune myocarditis and in human myocarditis. Circ J 2010; 74: 523-30. [CrossRef]
  • 5. Hemdahl AL, Gabrielsen A, Zhu C, Eriksson P, Hedin U, Kastrup J, et al. Expression of neutrophil gelatinase-associated lipocalin in atherosclerosis and myocardial infarction. Arterioscler Thromb Vasc Biol 2006; 26: 136-42. [CrossRef]
  • 6. Choi KM, Lee JS, Kim EJ, Baik SH, Seo HS, Choi DS, et al. Implication of lipocalin-2 and visfatin levels in patients with coronary heart disease. Eur J Endocrinol 2008; 158: 203-7. [CrossRef]
  • 7. Zografos T, Haliassos A, Korovesis S, Giazitzoglou E, Voridis E, Katritsis D. Association of neutrophil gelatinase-associated lipocalin with the severity of coronary artery disease. Am J Cardiol 2009; 104: 917-20. [CrossRef]
  • 8. Liu Q, Nilsen-Hamilton M. Identification of a new acute phase protein. J Biol Chem 1995; 270: 22565-70. [CrossRef]
  • 9. Kratchmarova I, Kalume DE, Blagoev B, Scherer PE, Podtelejnikov AV, Molina H, et al. A proteomic approach for identification of secreted proteins during the differentiation of 3T3-L1 preadipocytes to adipocytes. Mol Cell Proteomics 2002; 1: 213-22. [CrossRef]
  • 10. Fox KA, Dabbous OH, Goldberg RJ, Pieper KS, Eagle KA, Van de Werf F, et al. Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syn drome: prospective multinational observational study (GRACE). BMJ 2006; 333: 1091. [CrossRef]
  • 11. Gensini GG. A more meaningful scoring system for determining the severity of coronary artery disease. Am J Cardiol 1983; 51: 606. [CrossRef]
  • 12. Serruys PW, Morice MC, Kappetein AP, Colombo A, Holmes DR, Mack MJ, et al. Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease. N Engl J Med 2009; 360: 961-72. [CrossRef]
  • 13. SYNTAX working group. SYNTAX score calculator. Available at http://www.syntaxscore.com. Accessed May 20, 2012.
  • 14. Brown DL, Hibbs MS, Kearney M, Loushin C, Isner JM. Identification of 92-kD gelatinase in human coronary atherosclerotic lesions: association of active enzyme synthesis with unstable angina. Circulation 1995; 91: 2125-31. [CrossRef]
  • 15. Loftus IM, Naylor AR, Goodall S, Crowther M, Jones L, Bell PR, et al. Increased matrix metalloproteinase-9 activity in unstable carotid plaques: a potential role in acute plaque disruption. Stroke 2000; 31: 40-7. [CrossRef]
  • 16. Yan L, Borregaard N, Kjeldsen L, Moses MA. The high molecular weight urinary matrix metalloproteinase (MMP) activity is a complex of gelatinase B/MMP-9 and neutrophil gelatinase-associated lipocalin (NGAL). Modulation of MMP-9 activity by NGAL. J Biol Chem 2001; 276: 37258-65. [CrossRef]
  • 17. Şahinarslan A, Kocaman SA, Baş D, Akyel A, Erçin U, Zengin O, et al. Plasma neutrophil gelatinase-associated lipocalin levels in acute myocardial infarction and stable coronary artery disease. Coron Artery Dis 2011; 22: 333-8. [CrossRef]
  • 18. Lemesle G, Bonello L, de Labriolle A, Steinberg DH, Roy P, Pinto Slottow TL, et al. Prognostic value of the SYNTAX score in patients undergoing coronary artery bypass grafting for three-vessel coronary artery disease. Catheter Cardiovasc Interv 2009; 73: 612-7. [CrossRef]
  • 19. Capodanno D, Di Salvo ME, Cincotta G, Miano M, Tamburino C, Tamburino C. Usefulness of the SYNTAX score for predicting clinical outcome after percutaneous coronary intervention of unprotected left main coronary artery disease. Circ Cardiovasc Interv 2009; 2: 302-8. [CrossRef]
  • 20. Karakaş MF, Büyükkaya E, Kurt M, Motor S, Akçay AB, Büyükkaya S, et al. Serum pentraxin 3 levels are associated with the complexity and severity of coronary artery disease in patients with stable angina pectoris. J Investig Med 2013; 61: 278-85.
  • 21. Griva M, Naplava R, Spendlikova M, Jarkovsky J, Hlinomaz O, Cihalik C. Potential role of selected biomarkers for predicting the presence and extent of coronary artery disease. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2010; 154: 219-25. [CrossRef]
  • 22. Eagle KA, Lim MJ, Dabbous OH, Pieper KS, Goldberg RJ, Van de Werf F, et al. A validated prediction model for all forms of acute coronary syndrome: estimating the risk of 6-month postdischarge death in an international registry. JAMA 2004; 291: 2727-33. [CrossRef]
  • 23. Elneihoum AM, Falke P, Hedblad B, Lindgarde F, Ohlsson K. Leukocyte activation in atherosclerosis: correlation with risk factors. Atherosclerosis 1997; 131: 79-84. [CrossRef]
  • 24. Bolignano D, Donato V, Coppolino G, Campo S, Buemi A, Lacquaniti A, et al. Neutrophil gelatinase-associated lipocalin (NGAL) as a marker of kidney damage. Am J Kidney Dis 2008; 52: 595-605. [CrossRef]
  • 25. Bolignano D, Coppolino G, Campo S, Aloisi C, Nicocia G, Frisina N, et al. Urinary neutrophil gelatinase-associated lipocalin (NGAL) is associated with severity of renal disease in proteinuric patients. Nephrol Dial Transplant 2008; 23: 414-6. [CrossRef]
  • 26. Torregrosa I, Montoliu C, Urios A, Elmlili N, Puchades MJ, Solís MA, et al. Early biomarkers of acute kidney failure after heart angiography or heart surgery in patients with acute coronary syndrome or acute heart failure. Nefrologia 2012; 32: 44-52.
  • 27. Yan QW, Yang Q, Mody N, Graham TE, Hsu CH, Xu Z, et al. The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance. Diabetes 2007; 56: 2533-40. [CrossRef]
  • 28. Wang Y, Lam KS, Kraegen EW, Sweeney G, Zhang J, Tso AW, et al. Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, hyperglycemia in humans. Clin Chem 2007; 53: 34-41. [CrossRef]

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