Aim: Cadmium which is discovered in 1817 is a toxic heavy metal and found in phosphate fertilizers, detergents and refined petroleum and it's one of the major components of cigarette smoking. Selenium is an element, derived from unsaturated fatty acids, thought to degrade peroxides and needed to reduce - prevent the production of free radicals. Melatonin is the major hormone of the pineal gland and it is develops an antioxidant defense system to prevent cell damage caused by free radicals in organism. In our study, it was aimed to determine whether Selenium and Melatonin show antioxidant properties on the toxicity that cadmium accumulates on tissues in the body. Material Method: Experimental groups; Control (Group I), Cadmium (Cd) (Group II), Melatonin (Group III), Selenium (Group IV), Cadmium+Melatonin (Group V), Cadmium+Selenium (Group VI), Melatonin+Selenium (Group VII) and Cadmium + Melatonin + Selenium (Group VIII) were arranged to be8 female rats in each group. Cadmium (2 mg / kg / daywith gavage), Melatonin (3 mg / kg / day, intraperitoneal)30 days were applied once a day and seleneium wasapplied 6 times in 30 days, 5 days a day. At the end ofthe experiment, over, tuba uterine and uterus tissues weretaken. Some of the receiving tissues were in 10% neutralformaldehyde for histochemical and immunohistochemicalevaluation and the other were in phosphate buffer forbiochemical study and bloods were taken into the EDTAtube for apoptotic cell and DNA fragmentation assay.Results and Discussion: At the end of our study, MDAlevels were increased in the over, tubal uterine anduterine tissues according to the cadmium administrationgroup and also increase in GSPx and CAT activity valueswas detected, similar parameters were also observed ingroup III, group VII, group VIII. But in group V and groupVI, were found to inhibit lipid peroxidation of antioxidantsand decrease MDA, GSPx and CAT levels comparedto cadmium. As a result of the analysis with DNA ladderkit, DNA fragmentation and consequently apoptotic cellsnumber were observed only in the cadmium-administeredgroup. Histological and immunohistochemical findingsgave parallel results to biochemical analyzes and DNAladder values. in all the tissues of the cadmium group were observed; High MT-3 accumulation, damage (degenerationof ovarian follicles, haemorrhagic areas, mononuclear cellinfiltration and increased connective tissue; degenerationin tuba uterina epithelium and degeneration in tubules;degeneration in the uterine epithelium, dilate fields in theendometrium layer and degeneration in the endometrialglands) and increase in E-cadherin, NCAM synthesis.When significant improvements were observed in group VIand group VIII, there were no improvement in the group V.We have seen that cadmium brings damage to the femalegenital system organs and while selenium has protectiveeffect for tissues from this damage, Melatonin has not aprotective or corrective effect but we think, the cause of thisevent because of to hormonal changes of female rats andthe long-term use of Melatonin. At last, we hope that ourwork will contribute to cadmium treatment or protection andwill provide a stepping stone to new ways of treatment.