Brucellosis is primarily an animal disease, is transmitted to humans by meats, milk and milk products of infected animals, can be seen in very different clinical presentations. In this study, 16 patients who were followed up and treated with the diagnosis of Brucellosis in our clinic were evaluated retrospectively. The most frequent complaint of the cases was joint pain by 75%. Other frequent complaints were fever by 63%, weakness by 56%, joint swelling by 38%, abdominal pain, sweating, vomiting, body pain by 32%. The most frequent physical examination finding of the cases was fever by 63%. Hepatomegaly and/or splenomegaly were determined in 50% of the cases and lymphadenopathy was seen in 13% of them. All patients received treatment with two types of antibiotics, 13% of them (n=2) received three types of antibiotics. Three days after the initiation of treatment, the complaints of all patients were decreased. The treatments of all patients have been completed in six weeks. In two cases (13%), relapse was observed. One of these patients had been treated previously for a year in a different city. Other patient received dual therapy.