The clinical efficiency of acupuncture in preventing migraine attacks and its effect on serotonin levels

IŞIKSAÇAN, Nilgün; BOZKURT, Dilek; Gedikbasi, Asuman; BİÇER, Mualla; BAJRAMI, Arsida; Cabalar, Murat; Aktas, Ilknur

The clinical efficiency of acupuncture in preventing migraine attacks and its effect on serotonin levels

Mualla BİÇER, (Department of Physical Therapy and Rehabilitation, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey)

Dilek BOZKURT, (Department of Neurology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey)

Murat ÇABALAR, (Department of Neurology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey)

Nilgün IŞIKSAÇAN, (Department of Biochemistry, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey)

Asuman GEDİKBAŞI, (Department of Biochemistry, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey)

Arsida BAJRAMI, (Department of Neurology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey)

İlknur AKTAŞ (Department of Physical Therapy and Rehabilitation, Fatih Sultan Mehmet Training and Research Hospital, İstanbul, Turkey)

Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi

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Yıl: 2017 Cilt: 63 Sayı: 1 Sayfa Aralığı: 59 - 65 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The clinical efficiency of acupuncture in preventing migraine attacks and its effect on serotonin levels

Öz:

Amaç: Bu çalışmada akupunkturun migren ataklarının önlenmesindeki etkinliği araştırıldı.Hastalar ve yöntemler: Aralık 2013 - Haziran 2014 tarihleri arasında nöroloji kliniğimizde migren tanısını konan toplam 54 hasta rasgele iki gruba ayrıldı. Bir gruba (ilaç tedavisi grubu: 4 erkek, 21 kadın; ort. yaş 32.0±9.1 yıl; dağılım 18-65 yıl) üç ay süreyle venlafaksin uygulanırken, diğer grup (akupunktur grubu: 5 erkek, 24 kadın; ort. yaş 30.3±7.4 yıl; dağılım 18-65 yıl) akupunktur ile tedavi edildi. Kontrol grubu 29 sağlıklı bireyden (7 erkek, 22 kadın; ort. yaş 30.3±7.4 yıl; dağılım 18-65 yıl) oluşuyordu. Her iki grupta da görsel analog ölçeği (GAÖ) ve Migren Özürlülük Değerlendirmesi (MIDAS) ile birlikte tedavi öncesi ve sonrası kan serotonin düzeyleri ölçüldü. Bulgular: Akupunktur ve ilaç grubu arasında tedavi öncesi ve sonrası ortalama analjezik ilaç kullanımı ve GAÖ ve MIDAS skorları açısından istatistiksel olarak anlamlı fark saptanmadı (p>0.05). Atak sayı ve süresi, her iki grupta da tedavi öncesi değerlere kıyasla, anlamlı düzeyde düşük bulundu (p<0.0001). Akupunktur ve ilaç grubunda serotonin düzeyleri, tedavi öncesi değerlere kıyasla, anlamlı düzeyde yüksekti (p<0.0001). Çalışma gruplarına kıyasla, sağlıklı bireylerin serotonin düzeyleri, anlamlı düzeyde düşük bulundu (p<0.0001).Sonuç: Çalışma bulgularımıza göre, akupunktur, migren profilaksisinde etkili bir seçenek olabilir

Anahtar Kelime:

Konular: Rehabilitasyon

Akupunturun migren ataklarının önlenmesinde klinik etkinliği ve serotonin düzeylerine etkisi

Öz:

Objectives: This study aims to investigate the efficacy of acupuncture in preventing migraine attacks.Patients and methods: Between December 2013 and June 2014, a total of 54 patients with a diagnosis of migraine in our neurology clinic were randomized into two groups. Venlafaxine was administered for three months to one group (drug therapy group: 4 males, 21 females; mean age 32.0±9.1 years; range, 18 to 65 years), while the other group was treated with acupuncture (acupuncture group: 5 males, 24 females; mean age 30.3±7.4 years; range, 18 to 65 years). The control group consisted of a total of 29 healthy individuals (7 males, 22 females; mean age 30.3±7.4 years; range 18 to 65 years). Blood serotonin levels were assessed before and after treatment along with visual analog scale (VAS) and Migraine Disability Assessment (MIDAS) in both groups. Results: There was no statistically significant difference in the mean analgesic use before and after the treatment and VAS and MIDAS scores between the acupuncture and drug therapy groups (p>0.05). The number and duration of attacks was found to be significantly lower in both groups, compared to the pre-treatment values (p<0.0001). The serotonin levels in the acupuncture and drug therapy groups were significantly higher compared to the pre-treatment values (p<0.001). Serotonin levels were found to be significantly lower in healthy individuals compared to the study groups (p<0.0001).Conclusion: Based on our study findings, acupuncture may be an effective option in the migraine prophylaxis

Anahtar Kelime:

Konular: Rehabilitasyon

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Buse DC, Rupnow MF, Lipton RB. Assessing and managing all aspects of migraine: migraine attacks, migraine-related functional impairment, common comorbidities, and quality of life. Mayo Clin Proc 2009;84:422-35.
2. Saengjaroentham C, Supornsilpchai W, Ji-Au W, Srikiatkhachorn A, Maneesri-le Grand S. Serotonin depletion can enhance the cerebrovascular responses induced by cortical spreading depression via the nitric oxide pathway. Int J Neurosci 2015;125:130-9.
3. Danese E, Montagnana M, Lippi G. Platelets and migraine. Thromb Res 2014;134:17-22.
4. Schiapparelli P, Allais G, Rolando S, Airola G, Borgogno P, Terzi MG, et al. Acupuncture in primary headache treatment. Neurol Sci 2011;32:15-8.
5. Lu DP, Lu GP. An Historical Review and Perspective on the Impact of Acupuncture on U.S. Medicine and Society. Med Acupunct 2013;25:311-6.
6. Stewart WF, Lipton RB, Whyte J, Dowson A, Kolodner K, Liberman JN, et al. An international study to assess reliability of the Migraine Disability Assessment (MIDAS) score. Neurology 1999;53:988-94.
7. Li Y, Liang F, Yu S, Liu X, Tang Y, Yang X, et al. Randomized controlled trial to treat migraine with acupuncture: design and protocol. Trials 2008;9:57.
8. Zhang Y, Wang L, Liu H, Li N, Li J, Yi J. The design and protocol of acupuncture for migraine prophylaxis: a multicenter randomized controlled trial. Trials 2009;10:25.
9. He Y, Li Y, Nie Z. Typical aura without headache: a case report and review of the literature. J Med Case Rep 2015;9:40.
10. D’Andrea G, D’Amico D, Bussone G, Bolner A, Aguggia M, Saracco MG, et al. Tryptamine levels are low in plasma of chronic migraine and chronic tension-type headache. Neurol Sci 2014;35:1941-5.
11. Reddy DS. The pathophysiological and pharmacological basis of current drug treatment of migraine headache. Expert Rev Clin Pharmacol 2013;6:271-88.
12. Ozyalcin SN, Talu GK, Kiziltan E, Yucel B, Ertas M, Disci R. The efficacy and safety of venlafaxine in the prophylaxis of migraine. Headache 2005;45:144-52.
13. Bulut S, Berilgen MS, Baran A, Tekatas A, Atmaca M, Mungen B. Venlafaxine versus amitriptyline in the prophylactic treatment of migraine: randomized, double-blind, crossover study. Clin Neurol Neurosurg 2004;107:44-8.
14. Cui Y, Shu XO, Gao Y, Wen W, Ruan ZX, Jin F, et al. Use of complementary and alternative medicine by chinese women with breast cancer. Breast Cancer Res Treat 2004;85:263-70.
15. Sahin S, Bicer M, Eren GA, Tas S, Tugcu Tasci AI, et al. Acupuncture relieves symptoms in chronic prostatitis/chronic pelvic pain syndrome: a randomized, sham-controlled trial. Prostate Cancer Prostatic Dis 2015;18:249-54.
16. Chen Z, Hedner J, Hedner T. Substance P-induced respiratory excitation is blunted by delta-receptor specific opioids in the rat medulla oblongata. Acta Physiol Scand 1996;157:165-73.
17. Linde K, Allais G, Brinkhaus B, Manheimer E, Vickers A, White AR. Acupuncture for migraine prophylaxis. Cochrane Database Syst Rev 2009;1:001218.
18. Da Silva AN. Acupuncture for migraine prevention. Headache 2015;55:470-3.
19. Facco E, Liguori A, Petti F, Fauci AJ, Cavallin F, Zanette G. Acupuncture versus valproic acid in the prophylaxis of migraine without aura: a prospective controlled study. Minerva Anestesiol 2013;79:634-42.
20. Jia CS, Zheng LY, Shi J, Ma XS, Li XF, Li WL, et al. Effect of otopoint-needle embedment on headache and plasma 5-HT content in migraine patients. Zhen Ci Yan Jiu 2010;35:448- 52. [Abstract]
21. Karpa KD, Cavanaugh JE, Lakoski JM. Duloxetine pharmacology: profile of a dual monoamine modulator. CNS Drug Rev 2002;8:361-76.

APA	BİÇER M, BOZKURT D, Cabalar M, IŞIKSAÇAN N, Gedikbasi A, BAJRAMI A, Aktas I (2017). The clinical efficiency of acupuncture in preventing migraine attacks and its effect on serotonin levels. , 59 - 65.
Chicago	BİÇER Mualla,BOZKURT Dilek,Cabalar Murat,IŞIKSAÇAN Nilgün,Gedikbasi Asuman,BAJRAMI Arsida,Aktas Ilknur The clinical efficiency of acupuncture in preventing migraine attacks and its effect on serotonin levels. (2017): 59 - 65.
MLA	BİÇER Mualla,BOZKURT Dilek,Cabalar Murat,IŞIKSAÇAN Nilgün,Gedikbasi Asuman,BAJRAMI Arsida,Aktas Ilknur The clinical efficiency of acupuncture in preventing migraine attacks and its effect on serotonin levels. , 2017, ss.59 - 65.
AMA	BİÇER M,BOZKURT D,Cabalar M,IŞIKSAÇAN N,Gedikbasi A,BAJRAMI A,Aktas I The clinical efficiency of acupuncture in preventing migraine attacks and its effect on serotonin levels. . 2017; 59 - 65.
Vancouver	BİÇER M,BOZKURT D,Cabalar M,IŞIKSAÇAN N,Gedikbasi A,BAJRAMI A,Aktas I The clinical efficiency of acupuncture in preventing migraine attacks and its effect on serotonin levels. . 2017; 59 - 65.
IEEE	BİÇER M,BOZKURT D,Cabalar M,IŞIKSAÇAN N,Gedikbasi A,BAJRAMI A,Aktas I "The clinical efficiency of acupuncture in preventing migraine attacks and its effect on serotonin levels." , ss.59 - 65, 2017.
ISNAD	BİÇER, Mualla vd. "The clinical efficiency of acupuncture in preventing migraine attacks and its effect on serotonin levels". (2017), 59-65.

APA	BİÇER M, BOZKURT D, Cabalar M, IŞIKSAÇAN N, Gedikbasi A, BAJRAMI A, Aktas I (2017). The clinical efficiency of acupuncture in preventing migraine attacks and its effect on serotonin levels. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, 63(1), 59 - 65.
Chicago	BİÇER Mualla,BOZKURT Dilek,Cabalar Murat,IŞIKSAÇAN Nilgün,Gedikbasi Asuman,BAJRAMI Arsida,Aktas Ilknur The clinical efficiency of acupuncture in preventing migraine attacks and its effect on serotonin levels. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi 63, no.1 (2017): 59 - 65.
MLA	BİÇER Mualla,BOZKURT Dilek,Cabalar Murat,IŞIKSAÇAN Nilgün,Gedikbasi Asuman,BAJRAMI Arsida,Aktas Ilknur The clinical efficiency of acupuncture in preventing migraine attacks and its effect on serotonin levels. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, vol.63, no.1, 2017, ss.59 - 65.
AMA	BİÇER M,BOZKURT D,Cabalar M,IŞIKSAÇAN N,Gedikbasi A,BAJRAMI A,Aktas I The clinical efficiency of acupuncture in preventing migraine attacks and its effect on serotonin levels. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi. 2017; 63(1): 59 - 65.
Vancouver	BİÇER M,BOZKURT D,Cabalar M,IŞIKSAÇAN N,Gedikbasi A,BAJRAMI A,Aktas I The clinical efficiency of acupuncture in preventing migraine attacks and its effect on serotonin levels. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi. 2017; 63(1): 59 - 65.
IEEE	BİÇER M,BOZKURT D,Cabalar M,IŞIKSAÇAN N,Gedikbasi A,BAJRAMI A,Aktas I "The clinical efficiency of acupuncture in preventing migraine attacks and its effect on serotonin levels." Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, 63, ss.59 - 65, 2017.
ISNAD	BİÇER, Mualla vd. "The clinical efficiency of acupuncture in preventing migraine attacks and its effect on serotonin levels". Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi 63/1 (2017), 59-65.