Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats:

SEZER, Yavuz Atakan; Albayrak, Dogan; YALTA, Tülin Deniz; SAGIROGLU, TAMER; HATİPOĞLU, Ahmet Rahmi; OĞUZ, SERHAT; ERENOĞLU, Cengiz; GÜRCAN, Şaban

Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats:

Ahmet Rahmi HATİPOĞLU, (Trakya University)

Serhat OĞUZ, (Trakya University)

Şaban GÜRCAN, (Trakya University)

Tülin Deniz YALTA, (Trakya University)

Doğan ALBAYRAK, (Trakya University)

Cengiz ERENOĞLU, (Trakya University)

Tamer SAĞIROĞLU, (Trakya University)

Yavuz Atakan SEZER (Trakya University)

Balkan Medical Journal

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Yıl: 2013 Cilt: 30 Sayı: 4 Sayfa Aralığı: 362 - 368 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats:

Öz:

Background: Bacterial Translocation is believed to be an important factor on mortality and morbidity in Obstructive Jaundiced..Aims: We investigated the probable or estimated positive effects of tauroursodeoxycholic acid, which has antibacterial and regulatory effects on intestinal flora, together with glutamine on BT in an experimental obstructive jaundiced rat model. Study Design:Animal experimentation.Methods: Forty adult, male, Sprague Dawley rats were used in this study. Animals were randomised and divided into five groups of eight each: sham (Sh); control (common bile duct ligation, CBDL); and supplementation groups administered tauroursodeoxycholic acid (CBDL+T), glutamine (CBDL+G), or tauroursodeoxycholic acid plus glutamine (CBDL+TG). Blood and liver, spleen, MLN, and ileal samples were taken via laparotomy under sterile conditions for investigation of bacterial translocation and intestinal mucosal integrity and hepatic function tests on the tenth postoperative day. Results: There were statistically significant differences in BT rates in all samples except the spleen of the CBDL+TG group compared with the CBDL group (p=0.041, p=0.026, and p=0.041, respectively). Conclusion: It is essential to protect hepatic functions besides maintaining intestinal mucosal integrity in the active struggle against BT occurring in obstructive jaundice. The positive effect on intestinal mucosal integrity can be increased if glutamine is used with tauroursodeoxycholic acid, which also has hepatoprotective and immunomodulatory features.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	HATİPOĞLU A, OĞUZ S, GÜRCAN Ş, YALTA T, Albayrak D, ERENOĞLU C, SAGIROGLU T, SEZER Y (2013). Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats:. , 362 - 368.
Chicago	HATİPOĞLU Ahmet Rahmi,OĞUZ SERHAT,GÜRCAN Şaban,YALTA Tülin Deniz,Albayrak Dogan,ERENOĞLU Cengiz,SAGIROGLU TAMER,SEZER Yavuz Atakan Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats:. (2013): 362 - 368.
MLA	HATİPOĞLU Ahmet Rahmi,OĞUZ SERHAT,GÜRCAN Şaban,YALTA Tülin Deniz,Albayrak Dogan,ERENOĞLU Cengiz,SAGIROGLU TAMER,SEZER Yavuz Atakan Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats:. , 2013, ss.362 - 368.
AMA	HATİPOĞLU A,OĞUZ S,GÜRCAN Ş,YALTA T,Albayrak D,ERENOĞLU C,SAGIROGLU T,SEZER Y Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats:. . 2013; 362 - 368.
Vancouver	HATİPOĞLU A,OĞUZ S,GÜRCAN Ş,YALTA T,Albayrak D,ERENOĞLU C,SAGIROGLU T,SEZER Y Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats:. . 2013; 362 - 368.
IEEE	HATİPOĞLU A,OĞUZ S,GÜRCAN Ş,YALTA T,Albayrak D,ERENOĞLU C,SAGIROGLU T,SEZER Y "Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats:." , ss.362 - 368, 2013.
ISNAD	HATİPOĞLU, Ahmet Rahmi vd. "Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats:". (2013), 362-368.

APA	HATİPOĞLU A, OĞUZ S, GÜRCAN Ş, YALTA T, Albayrak D, ERENOĞLU C, SAGIROGLU T, SEZER Y (2013). Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats:. Balkan Medical Journal, 30(4), 362 - 368.
Chicago	HATİPOĞLU Ahmet Rahmi,OĞUZ SERHAT,GÜRCAN Şaban,YALTA Tülin Deniz,Albayrak Dogan,ERENOĞLU Cengiz,SAGIROGLU TAMER,SEZER Yavuz Atakan Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats:. Balkan Medical Journal 30, no.4 (2013): 362 - 368.
MLA	HATİPOĞLU Ahmet Rahmi,OĞUZ SERHAT,GÜRCAN Şaban,YALTA Tülin Deniz,Albayrak Dogan,ERENOĞLU Cengiz,SAGIROGLU TAMER,SEZER Yavuz Atakan Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats:. Balkan Medical Journal, vol.30, no.4, 2013, ss.362 - 368.
AMA	HATİPOĞLU A,OĞUZ S,GÜRCAN Ş,YALTA T,Albayrak D,ERENOĞLU C,SAGIROGLU T,SEZER Y Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats:. Balkan Medical Journal. 2013; 30(4): 362 - 368.
Vancouver	HATİPOĞLU A,OĞUZ S,GÜRCAN Ş,YALTA T,Albayrak D,ERENOĞLU C,SAGIROGLU T,SEZER Y Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats:. Balkan Medical Journal. 2013; 30(4): 362 - 368.
IEEE	HATİPOĞLU A,OĞUZ S,GÜRCAN Ş,YALTA T,Albayrak D,ERENOĞLU C,SAGIROGLU T,SEZER Y "Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats:." Balkan Medical Journal, 30, ss.362 - 368, 2013.
ISNAD	HATİPOĞLU, Ahmet Rahmi vd. "Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats:". Balkan Medical Journal 30/4 (2013), 362-368.