Yıl: 2017 Cilt: 34 Sayı: 1 Sayfa Aralığı: 42 - 51 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Düşük-dereceli ve Yüksek-dereceli Gliomlu Hastaların Dokularında Selektin, Lökosit Hücre Adezyon Molekülü ve Platelet Endotel Hücre Adezyon Molekülü-1 Seviyeleri

Öz:
Giriş: Adezyon molekülleri inflamasyonda, tümör hücresi progresyonunda ve invazyonunda önemli bir rol oynamaktadır. Burada, selektin (E-, L-, ve P-selektin), aktiflenmiş lökosit hücre adezyon molekülü (ALHAM) ve platelet endotel hücre adezyon molekülü-1 (PEHAM-1) doku seviyeleri glial tümörlü hastalarda ve kontrol grubunda incelenmiştir. Yöntem: Toplam 39 hasta (19 düşük-dereceli ve 20 yüksek-dereceli gliom) ve travma sonrası otopsi uygulanan 15 kontrol grubu çalışmaya dahil edilmiştir. Adezyon molekülleri ELISA yöntemi ile ölçülmüş ve sonuçlar karşılaştırılmıştır. Bulgular: Her bir molekül düşünüldüğünde kontrol ve hasta grupları arasında istatistiksel olarak anlamlı fark bulunmuştur (P < 0.05). Bunlara ek olarak, yüksek-dereceli gliomlarda düşük-dereceli gliomlara nazaran anlamlı yüksek seviyeler bulunmuştur. Sonuç: Bu sonuçlar, adezyon moleküllerinin gliom oluşmasında rol alabileceğini ve bu moleküllere yönelik ileride geliştirilebilecek hedef tedavilerin bu yıkıcı beyin tümörlerinde yardımcı olabileceğini düşündürmektedir.
Anahtar Kelime:

Konular: Hücre ve Doku Mühendisliği Hematoloji Onkoloji Hücre Biyolojisi

Selectins, Activated Leukocyte Cell Adhesion Molecule, and Platelet Endothelial Cell Adhesion Molecule-1 Tissue Levels in Patients With Low- and High-grade Gliomas

Öz:
Background: Adhesion molecules play an important role(s) in inflammation, tumor cell progression and invasion. Here we investigated tissue levels of selectins (E-, L-, and Pselectins), activated leukocyte cell adhesion molecules (ALCAM), and platelet endothelial cell adhesion molecules-1 (PECAM-1) in a series of patients with glial tumors and controls. Methods: A total of 39 patients, 19 with low-grade gliomas and 20 with high-grade gliomas, and 15 deceased controls who underwent autopsy after trauma were included. Adhesion molecules were measured using enzyme-linked immunosorbent assay and the results were analyzed. Results: Statistically significant differences were found between the patients and controls regarding every molecule (p<0.05). Furthermore, significantly higher levels were found in patients with high-grade gliomas compared with those with low-grade gliomas. Conclusion: These results suggest that adhesion molecules may have a role in glioma formation and targeted therapies could help in the treatment of these devastating brain tumors.
Anahtar Kelime:

Konular: Hücre ve Doku Mühendisliği Hematoloji Onkoloji Hücre Biyolojisi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA TANRIVERDİ T, SAYYAHMELLI S, KEMERDERE R, ATUKEREN P, EREN B (2017). Düşük-dereceli ve Yüksek-dereceli Gliomlu Hastaların Dokularında Selektin, Lökosit Hücre Adezyon Molekülü ve Platelet Endotel Hücre Adezyon Molekülü-1 Seviyeleri. , 42 - 51.
Chicago TANRIVERDİ Taner,SAYYAHMELLI Sima,KEMERDERE Rahşan,ATUKEREN Pınar,EREN Bülent Düşük-dereceli ve Yüksek-dereceli Gliomlu Hastaların Dokularında Selektin, Lökosit Hücre Adezyon Molekülü ve Platelet Endotel Hücre Adezyon Molekülü-1 Seviyeleri. (2017): 42 - 51.
MLA TANRIVERDİ Taner,SAYYAHMELLI Sima,KEMERDERE Rahşan,ATUKEREN Pınar,EREN Bülent Düşük-dereceli ve Yüksek-dereceli Gliomlu Hastaların Dokularında Selektin, Lökosit Hücre Adezyon Molekülü ve Platelet Endotel Hücre Adezyon Molekülü-1 Seviyeleri. , 2017, ss.42 - 51.
AMA TANRIVERDİ T,SAYYAHMELLI S,KEMERDERE R,ATUKEREN P,EREN B Düşük-dereceli ve Yüksek-dereceli Gliomlu Hastaların Dokularında Selektin, Lökosit Hücre Adezyon Molekülü ve Platelet Endotel Hücre Adezyon Molekülü-1 Seviyeleri. . 2017; 42 - 51.
Vancouver TANRIVERDİ T,SAYYAHMELLI S,KEMERDERE R,ATUKEREN P,EREN B Düşük-dereceli ve Yüksek-dereceli Gliomlu Hastaların Dokularında Selektin, Lökosit Hücre Adezyon Molekülü ve Platelet Endotel Hücre Adezyon Molekülü-1 Seviyeleri. . 2017; 42 - 51.
IEEE TANRIVERDİ T,SAYYAHMELLI S,KEMERDERE R,ATUKEREN P,EREN B "Düşük-dereceli ve Yüksek-dereceli Gliomlu Hastaların Dokularında Selektin, Lökosit Hücre Adezyon Molekülü ve Platelet Endotel Hücre Adezyon Molekülü-1 Seviyeleri." , ss.42 - 51, 2017.
ISNAD TANRIVERDİ, Taner vd. "Düşük-dereceli ve Yüksek-dereceli Gliomlu Hastaların Dokularında Selektin, Lökosit Hücre Adezyon Molekülü ve Platelet Endotel Hücre Adezyon Molekülü-1 Seviyeleri". (2017), 42-51.
APA TANRIVERDİ T, SAYYAHMELLI S, KEMERDERE R, ATUKEREN P, EREN B (2017). Düşük-dereceli ve Yüksek-dereceli Gliomlu Hastaların Dokularında Selektin, Lökosit Hücre Adezyon Molekülü ve Platelet Endotel Hücre Adezyon Molekülü-1 Seviyeleri. Journal of Neurological Sciences (Turkish), 34(1), 42 - 51.
Chicago TANRIVERDİ Taner,SAYYAHMELLI Sima,KEMERDERE Rahşan,ATUKEREN Pınar,EREN Bülent Düşük-dereceli ve Yüksek-dereceli Gliomlu Hastaların Dokularında Selektin, Lökosit Hücre Adezyon Molekülü ve Platelet Endotel Hücre Adezyon Molekülü-1 Seviyeleri. Journal of Neurological Sciences (Turkish) 34, no.1 (2017): 42 - 51.
MLA TANRIVERDİ Taner,SAYYAHMELLI Sima,KEMERDERE Rahşan,ATUKEREN Pınar,EREN Bülent Düşük-dereceli ve Yüksek-dereceli Gliomlu Hastaların Dokularında Selektin, Lökosit Hücre Adezyon Molekülü ve Platelet Endotel Hücre Adezyon Molekülü-1 Seviyeleri. Journal of Neurological Sciences (Turkish), vol.34, no.1, 2017, ss.42 - 51.
AMA TANRIVERDİ T,SAYYAHMELLI S,KEMERDERE R,ATUKEREN P,EREN B Düşük-dereceli ve Yüksek-dereceli Gliomlu Hastaların Dokularında Selektin, Lökosit Hücre Adezyon Molekülü ve Platelet Endotel Hücre Adezyon Molekülü-1 Seviyeleri. Journal of Neurological Sciences (Turkish). 2017; 34(1): 42 - 51.
Vancouver TANRIVERDİ T,SAYYAHMELLI S,KEMERDERE R,ATUKEREN P,EREN B Düşük-dereceli ve Yüksek-dereceli Gliomlu Hastaların Dokularında Selektin, Lökosit Hücre Adezyon Molekülü ve Platelet Endotel Hücre Adezyon Molekülü-1 Seviyeleri. Journal of Neurological Sciences (Turkish). 2017; 34(1): 42 - 51.
IEEE TANRIVERDİ T,SAYYAHMELLI S,KEMERDERE R,ATUKEREN P,EREN B "Düşük-dereceli ve Yüksek-dereceli Gliomlu Hastaların Dokularında Selektin, Lökosit Hücre Adezyon Molekülü ve Platelet Endotel Hücre Adezyon Molekülü-1 Seviyeleri." Journal of Neurological Sciences (Turkish), 34, ss.42 - 51, 2017.
ISNAD TANRIVERDİ, Taner vd. "Düşük-dereceli ve Yüksek-dereceli Gliomlu Hastaların Dokularında Selektin, Lökosit Hücre Adezyon Molekülü ve Platelet Endotel Hücre Adezyon Molekülü-1 Seviyeleri". Journal of Neurological Sciences (Turkish) 34/1 (2017), 42-51.