TANER TANRIVERDİ
(Istanbul University)
Sima SAYYAHMELLI
(Istanbul University)
Rahşan KEMERDERE
(Istanbul University)
Pınar ATUKEREN
(Istanbul University)
Bülent EREN
(Counsil of Forensic Medicine)
Yıl: 2017Cilt: 34Sayı: 1ISSN: 1300-1817 / 1302-1664Sayfa Aralığı: 42 - 51Türkçe

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Düşük-dereceli ve Yüksek-dereceli Gliomlu Hastaların Dokularında Selektin, Lökosit Hücre Adezyon Molekülü ve Platelet Endotel Hücre Adezyon Molekülü-1 Seviyeleri
Giriş: Adezyon molekülleri inflamasyonda, tümör hücresi progresyonunda ve invazyonunda önemli bir rol oynamaktadır. Burada, selektin (E-, L-, ve P-selektin), aktiflenmiş lökosit hücre adezyon molekülü (ALHAM) ve platelet endotel hücre adezyon molekülü-1 (PEHAM-1) doku seviyeleri glial tümörlü hastalarda ve kontrol grubunda incelenmiştir. Yöntem: Toplam 39 hasta (19 düşük-dereceli ve 20 yüksek-dereceli gliom) ve travma sonrası otopsi uygulanan 15 kontrol grubu çalışmaya dahil edilmiştir. Adezyon molekülleri ELISA yöntemi ile ölçülmüş ve sonuçlar karşılaştırılmıştır. Bulgular: Her bir molekül düşünüldüğünde kontrol ve hasta grupları arasında istatistiksel olarak anlamlı fark bulunmuştur (P < 0.05). Bunlara ek olarak, yüksek-dereceli gliomlarda düşük-dereceli gliomlara nazaran anlamlı yüksek seviyeler bulunmuştur. Sonuç: Bu sonuçlar, adezyon moleküllerinin gliom oluşmasında rol alabileceğini ve bu moleküllere yönelik ileride geliştirilebilecek hedef tedavilerin bu yıkıcı beyin tümörlerinde yardımcı olabileceğini düşündürmektedir.
Fen > Mühendislik > Hücre ve Doku Mühendisliği
Fen > Tıp > Hücre Biyolojisi
Fen > Tıp > Hematoloji
Fen > Tıp > Onkoloji
DergiAraştırma MakalesiErişime Açık
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