Acute ischemia of peripheral nerves generally results from occlusion of a main proximal limb artery or from occlusion of many distal arteries. The rareness of such neuropathies can be explained by the relative resistance of peripheral nerves to ischemia. Leriche syndrome is an aortoiliac occlusive disease that is known to cause neurologic complications such as ischemic neuropathy and spinal cord ischemia. Here, we present a man aged 55 years with bilateral lumbosacral plexopathy that presented as acute paraparesia due to thrombotic occlusion of an axillobifemoral graft, which was performed for the treatment of Leriche syndrome.