AYŞEGÜL GÜNDÜZ
(Department of Neurology, Cerrahpasa School of Medicine, Istanbul University)
Meral E. KIZILTAN
(Department of Neurology, Cerrahpasa School of Medicine, Istanbul University)
Hatice KUMRU
(Institut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, Barcelona, Spain)
SEMRA OĞUZ
(Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Marmara University)
GÜNEŞ KIZILTAN
(Department of Neurology, Cerrahpasa School of Medicine, Istanbul University)
Sibel ERTAN
(Department of Neurology, Cerrahpasa School of Medicine, Istanbul University)
HÜLYA APAYDIN
(Department of Neurology, Cerrahpasa School of Medicine, Istanbul University)
Yıl: 2017Cilt: 34Sayı: 3ISSN: 1300-1817 / 1302-1664Sayfa Aralığı: 215 - 221İngilizce

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Cortical Relay Time Shortens in Parkinson's Disease with Apraxia
Kortikal röle zamanı (KRZ), duyusal ve motor korteksler arasındaki iletimi ölçen nörofizyolojik yöntemdir. Bu çalışmada, hemisfer içindeki iletimi değerlendirmek amacıyla idiyopatik Parkinson hastalığında (PH) KRZ ölçüldü. Uzun latanslı refleksler (LLR), motor uyandırılmış potansiyel (MEP) ve somatosensoriyel uyandırılmış potansiyel (SEP) incelemeleri daha önce bildirilen yazılara uygun olarak yapıldı ve KRZ aşağıdaki formül kullanılarak hesaplandı: LLR II latansı- (MEP başlangıç latansı + SEP N20 latansı). KRZ, apraksi olan hastalarda olmayan hastalara oranla daha kısaydı. Bulgularımız, PH'da apraksi varlığında hemisfer içinde anormal iletim olasılığı veya anormal sinaptik organizasyon varlığını akla getirmektedir
Fen > Tıp > Nörolojik Bilimler
DergiAraştırma MakalesiErişime Açık
  • 1. Deuschl G, Schenck E, Lücking CH. Long-latency responses in human thenar muscles mediated by fast conducting muscle and cutaneous afferents. Neurosci Lett 1985; 55: 361-6.
  • 2. Tataroglu C, Genc A, Idiman E, Cakmur R, Idiman F. Cortical relay time for long latency reflexes in patients with definite multiple sclerosis. Can J Neurol Sci 2004; 31: 229-34.
  • 3. Canafoglia L, Ciano C, Panzica F, et al. Sensorimotor cortex excitability in UnverrichtLundborg disease and Lafora body disease. Neurology 2004; 63: 2309-15.
  • 4. Zadikoff C, Lang AE. Apraxia in movement disorders. Brain 2005; 128: 1480-97.
  • 5. Leiguarda RC, Pramstaller PP, Merello M, et al. Apraxia in Parkinson's disease, progressive supranuclear palsy, multiple system atrophy and neuroleptic-induced parkinsonism. Brain 1997; 120: 75-90.
  • 6. Uluduz D, Ertürk O, Kenangil G, et al. Apraxia in Parkinson's disease and multiple system atrophy. Eur J Neurol 2010; 17: 413-8.
  • 7. Kokmen E, Ozekmekci FS, Cha RH, O'Brien PJ. Testing for apraxia in neurological patients: a descriptive study in two diverse cultures. Eur J Neurol 1998; 5: 175-80.
  • 8. Valls-Sole J, Deuschl G. Reflex responses, silent period and long-latency responses. In: Kimura J, editor. Peripheral nerve diseases, Amsterdam: Elsevier. 2006, p. 237-62.
  • 9. Bonfiglio L, Rossi B, Sartucci F. Prolonged intracortical delay of long-latency reflexes: electrophysiological evidence for a cortical dysfunction in multiple sclerosis. Brain Res Bull 2006; 69: 606-13.
  • 10. Iturria-Medina Y. Anatomical brain networks on the prediction of abnormal brain states. Brain Connect 2013; 3: 1-21.
  • 11. Wu T, Wang J, Wang C, et al. Basal ganglia circuits changes in Parkinson's disease patients. Neurosci Lett 2012; 524: 55-9.
  • 12. Tessitore A, Esposito F, Vitale C, et al. Defaultmode network connectivity in cognitively unimpaired patients with Parkinson disease. Neurology 2012; 79: 2226-32.
  • 13. van Eimeren T, Monchi O, Ballanger B, et al. Dysfunction of the default mode network in Parkinson disease: a functional magnetic resonance imaging study. Arch Neurol 2009; 66: 877-83.
  • 14. Foki T, Pirker W, Geißler A, et al. Finger dexterity deficits in Parkinson's disease and somatosensory cortical dysfunction. Parkinsonism Relat Disord 2015; 21: 259-65.
  • 15. Foki T, Pirker W, Klinger N, et al. FMRI correlates of apraxia in Parkinson's disease patients OFF medication. Exp Neurol 2010; 225: 416-22.
  • 16. Rottschy C, Kleiman A, Dogan I, et al. Diminished activation of motor working-memory networks in Parkinson's disease. PLoS One 2013; 8: e61786.
  • 17. Zaltieri M, Grigoletto J, Longhena F, et al.. α- synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons. J Cell Sci 2015; 128: 2231-43.
  • 18. Kojovic M, Bologna M, Kassavetis P, et al. Functional reorganization of sensorimotor cortex in early Parkinson disease. Neurology 2012 1; 78: 1441-8.
  • 19. Heilmann KM, Valenstein E, Rothi LJG, Watson RT. Intentional Motor Disorders and the Apraxias. In: Bradley WG, Daroff RB, Fenichel GM, Jankovic J, editors. Neurology in Clinical Practice. Principles of Diagnosis and Management. Volume 1. Philadelphia: Butterworth-Heinemann. 2004, p. 117-30.

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