Yıl: 2017 Cilt: 34 Sayı: 3 Sayfa Aralığı: 231 - 241 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The Effect of Memantine on Cognitive Performance with Amnestic Mild Cognitive Impairment

Öz:
Amaç: Amnestik hafif kognitif bozukluk (aMCI) normal bilişsel gerileme ve çok erken demans döneminde ortaya çıkan bilişsel değişimleri ifade eder. Biz aMCI hastalarında tedavide kullanılan memantin etkinliğini değerlendirmeyi amaçladık. Metod: Tüm hastalara Petersen kriterlerine göre aMCI tanısı kondu ve üç gruba ayrıldı. Grup 1, muayene sonrası memantin başlanan hastalardan oluştu (n=23), Grup 2'de muayene sonrası memantin tedavisi almayan hastalar (n=22), Grup 3 sağlıklı yaşa uygun gönüllülerden (n=20) oluşuyordu. Muayeneleri takiben demans polikliniğimizde kullanılan Turkuaz Alzheimer Çalışma Grubu veri tabanından nöropsikiyatrik testler yapıldı. Sonuçlar: Hastaların yaş ortalaması Grup 1'de 66±7.04, Grup 2'de 65.3±6.20 ve Grup 3'te 57.6±5.40 idi. Grup 1'deki en belirgin iyileşme Mini Mental Durum Muayenesinde (MMSE), Wechsler bellek ölçeği alt grup testleri, Blessed Demans Derecelendirme Ölçeği (BDRS), Boston adlandırma testinde (BNT) görüldü (p<0.05). Memantinin tedavisi, 24 haftalık çalışma süresi boyunca Geriatrik Demans Ölçeği skorlarında düzelme ile ilişkiliydi. Tartışma: Bu sonuçlar memantinin aMCI hastalarında tedavi almayan grupla karşılaştırıldığında bilişsel işlevsellik düzeyini artırdığını göstermektedir. Bu bulgular, plasebo kontrollü daha geniş randomize bir çalışmaya ihtiyaç olduğunu ortaya koymaktadır
Anahtar Kelime:

Konular: Nörolojik Bilimler

Memantin’in Amnestik Hafif Kognitif Bozuklukta Kognitif Performans Üzerine Etkisi

Öz:
Objective: Amnestic mild cognitive impairment (aMCI) refers to cognitive changes that occur during the period of normal cognitive decline and very early dementia. We aimed to assess the efficacy of memantine used for the treatment of patients with aMCI. Methods: All patients were diagnosed as having aMCI according to the Petersen criteria and were assigned to one of three groups. Group 1 comprised patients who received memantine following examination (n=23), group 2 included patients who did not receive memantine treatment following examination (n=22), and group 3 was constituted by healthy age-matched volunteers (n=20). Following the examinations, neuropsychiatric tests from the Turquoise Alzheimer"s Study Group database used in dementia polyclinics were performed. Results: The mean age of patients was 66±7.04 years in group 1, 65.3±6.20 years in group 2, and 57.6±5.40 years in group 3. The most noticeable improvements in group 1 were seen in the Mini-Mental State Exam, Wechsler memory scale subtests, Blessed Dementia Rating Scale, and the Boston Naming Test (p<0.05). Treatment with memantine was associated with an improvement in Geriatric Dementia Scale scores over the 24- week study period. Conclusion: These results suggest that memantine treatment in patients with aMCI acts to enhance cognitive functioning compared with no treatment. These findings suggest the need for a larger randomized placebo-controlled trial
Anahtar Kelime:

Konular: Nörolojik Bilimler
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA ILHAN ALGIN D, DAGLI ATALAY S, Ozkan S, OZBABALIK ADAPINAR D (2017). The Effect of Memantine on Cognitive Performance with Amnestic Mild Cognitive Impairment. , 231 - 241.
Chicago ILHAN ALGIN Demet,DAGLI ATALAY Suna,Ozkan Serhat,OZBABALIK ADAPINAR Demet The Effect of Memantine on Cognitive Performance with Amnestic Mild Cognitive Impairment. (2017): 231 - 241.
MLA ILHAN ALGIN Demet,DAGLI ATALAY Suna,Ozkan Serhat,OZBABALIK ADAPINAR Demet The Effect of Memantine on Cognitive Performance with Amnestic Mild Cognitive Impairment. , 2017, ss.231 - 241.
AMA ILHAN ALGIN D,DAGLI ATALAY S,Ozkan S,OZBABALIK ADAPINAR D The Effect of Memantine on Cognitive Performance with Amnestic Mild Cognitive Impairment. . 2017; 231 - 241.
Vancouver ILHAN ALGIN D,DAGLI ATALAY S,Ozkan S,OZBABALIK ADAPINAR D The Effect of Memantine on Cognitive Performance with Amnestic Mild Cognitive Impairment. . 2017; 231 - 241.
IEEE ILHAN ALGIN D,DAGLI ATALAY S,Ozkan S,OZBABALIK ADAPINAR D "The Effect of Memantine on Cognitive Performance with Amnestic Mild Cognitive Impairment." , ss.231 - 241, 2017.
ISNAD ILHAN ALGIN, Demet vd. "The Effect of Memantine on Cognitive Performance with Amnestic Mild Cognitive Impairment". (2017), 231-241.
APA ILHAN ALGIN D, DAGLI ATALAY S, Ozkan S, OZBABALIK ADAPINAR D (2017). The Effect of Memantine on Cognitive Performance with Amnestic Mild Cognitive Impairment. Journal of Neurological Sciences (Turkish), 34(3), 231 - 241.
Chicago ILHAN ALGIN Demet,DAGLI ATALAY Suna,Ozkan Serhat,OZBABALIK ADAPINAR Demet The Effect of Memantine on Cognitive Performance with Amnestic Mild Cognitive Impairment. Journal of Neurological Sciences (Turkish) 34, no.3 (2017): 231 - 241.
MLA ILHAN ALGIN Demet,DAGLI ATALAY Suna,Ozkan Serhat,OZBABALIK ADAPINAR Demet The Effect of Memantine on Cognitive Performance with Amnestic Mild Cognitive Impairment. Journal of Neurological Sciences (Turkish), vol.34, no.3, 2017, ss.231 - 241.
AMA ILHAN ALGIN D,DAGLI ATALAY S,Ozkan S,OZBABALIK ADAPINAR D The Effect of Memantine on Cognitive Performance with Amnestic Mild Cognitive Impairment. Journal of Neurological Sciences (Turkish). 2017; 34(3): 231 - 241.
Vancouver ILHAN ALGIN D,DAGLI ATALAY S,Ozkan S,OZBABALIK ADAPINAR D The Effect of Memantine on Cognitive Performance with Amnestic Mild Cognitive Impairment. Journal of Neurological Sciences (Turkish). 2017; 34(3): 231 - 241.
IEEE ILHAN ALGIN D,DAGLI ATALAY S,Ozkan S,OZBABALIK ADAPINAR D "The Effect of Memantine on Cognitive Performance with Amnestic Mild Cognitive Impairment." Journal of Neurological Sciences (Turkish), 34, ss.231 - 241, 2017.
ISNAD ILHAN ALGIN, Demet vd. "The Effect of Memantine on Cognitive Performance with Amnestic Mild Cognitive Impairment". Journal of Neurological Sciences (Turkish) 34/3 (2017), 231-241.